63 research outputs found
Cardiovascular effects of intracerebro-ventricular bradykinin and melittin in the rat
No full textAbstract
The cardiovascular effects of intracerebroventricular (i.c.v.) bradykinin and melittin were investigated in the anaesthetized rat. Bradykinin, 30 μg, increased mean arterial pressure by 15 mmHg and this was the result of an increase in peripheral resistance; heart rate and cardiac output were unchanged. Tissue blood flow was lower in the skin and spleen in the animals given bradykinin than the controls. Significant increases in tissue vascular resistance occurred in the skin and several organs of the splanchnic region, the spleen, stomach, large intestine and the pancreas/mesentery. Melittin infusion gave a biphasic response in systemic blood pressure in which a depressor response was followed by a pressor phase; the pressor stage was accompanied by an increase in heart rate. Since melittin is a stimulant of membrane bound kallikrein, the results lend limited support to the hypothesis that there is a kallikrein-kinin system endogenous to the central nervous system which is involved in cardiovascular regulation.</jats:p
Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor
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Effect of neuropeptide Y on cardiac output, its distribution, regional blood flow and organ vascular resistances in the pithed rat
No full textNetwork developing forensic applications of stable isotope ratio mass spectrometry conference 2005
No full textProf. Max Coleman of Reading University and Sean Doyle of the Forensic Explosives Laboratory (FEL), Dstl, formed the Forensic Isotope Ratio Mass Spectrometry (FIRMS) Network in 2002. As part of the continuing network development the second FIRMS conference, FIRMS 2005, was held at the Thistle Hotel, Brands Hatch, Kent on the 9th and 10th March 2005. The conference aimed to bring together IRMS researchers, end users and instrument manufacturers. The objectives of the conference were to exchange information between the researchers and end users; expand the network; review the requirement; assess the strategy for development; and chart progress since the first FIRMS conference. The conference was a mix of presentations and discussion sessions. A summary of each presentation and the discussions are given in this paper. Sean Doyle welcomed everyone to the second FIRMS conference and thanked participants for their continued support of the network. Dr. Robin Hiley, Chief Technologist, Energetics Department, Dstl was then introduced as the chairperson for the first day
The kinematics of false intent Conveyed by deceptive sidestep actions
No full textResearchers have identified kinematic differences between deceptive and non-deceptive rugby reorientation actions. However, the honest and deceptive signals corresponded to ‘deception detection’ (accuracy increasing) rather than signals that caused deception (accuracy decreasing). In this study, statistical parametric mapping and multilevel modelling were applied to examine the kinematic differences between sidestep and non-deceptive actions during the time window of deception. The analysis compared three-dimensional motion capture data from 144 deceptive actions and 144 genuine actions performed by six high-skilled rugby players. Results indicated that the kinematics of deceptive actions were characterized by a combination of exaggerated head roll, outside foot and centre-of-mass displacement, and attenuated thorax roll and yaw relative to genuine actions. These are candidate sources for the cause of deception, either individually or in combination with other sources. Furthermore, the results indicate that previously identified ‘honest’ signals may not be reliable sources of information earlier in the action sequence
Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism
No full textComparative studies of the angiogenic activity of vasoactive intestinal peptide, endothelins‐1 and −3 and angiotensin II in a rat sponge model
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