10,252 research outputs found
Can the ischemic penumbra be identified on noncontrast CT of acute stroke?
No full text<p><b>Background and Purpose:</b> Early ischemic changes on noncontrast CT in acute stroke include both hypoattenuation and brain swelling, which may have different pathophysiological significance.</p>
<p><b>Methods:</b> Noncontrast CT and CT perfusion brain scans from patients with suspected acute stroke <6 hours after onset were reviewed. Five raters independently scored noncontrast CTs blind to clinical data using the Alberta Stroke Program Early CT Score (ASPECTS). Each ASPECTS region was scored as hypodense or swollen. A separate reviewer measured time to peak and cerebral blood volume in each ASPECTS region on CT perfusion. Time to peak and cerebral blood volume were compared for each region categorized as normal, hypodense, or isodense and swollen.</p>
<p><b>Results:</b> Scans of 32 subjects a median 155 minutes after onset yielded 228 regions with both CT perfusion and noncontrast CT data. Isodense swelling was associated with significantly higher cerebral blood volume (P=0.016) and with penumbral perfusion (posttest:pretest likelihood ratio 1.44 [95% CI: 0.68 to 2.90]), whereas hypodensity was associated with more severe time to peak delay and with core perfusion (likelihood ratio 3.47 [95% CI: 1.87 to 6.34]). Neither isodense swelling nor hypodensity was sensitive for prediction of perfusion pattern, but appearances were highly specific (87.2% and 91.0% for penumbra and core, respectively). Intrarater agreement was good or excellent, but interrater agreement for both hypodensity and swelling was poor.</p>
<p><b>Conclusions:</b> Regions exhibiting hypoattenuation are likely to represent the infarct core, whereas regions that are isodense and swollen have increased cerebral blood volume and are more likely to signify penumbral perfusion. Although noncontrast CT is not sensitive for detection of core and penumbra, appearances are specific. Some information on tissue viability can therefore be obtained from noncontrast CT.</p>
Application of CT in Diagnosing Carcinoma of the Maxillary Sinuses : PART 2: An Experimental Study of Pitfalls Encountered when Diagnosing Carcinoma of the Maxillary Sinuses with CT
No full text1982-03A phantom simulating the transverse section of the maxillary sinuses was constructed for experimentation with various CT scanners to study the following: (1) the occasional inability to image the very thin posterior-lateral walls which have no real bone defects, and (2) to verify whether or not the bony walls surrounding the maxillary sinuses are actually as thick as they appear on CT. The phantom was made of an acrylic cylinder containing three cavities simulating the maxillary sinuses and the nasal cavity and filled with water. The walls, made of thin aluminum and acrylic plates and placed between water and air, disappeared in some CT images. The thickness of the walls calculated from CT values was greater than the true thickness imaged by each CT scanner. The author stresses that in CT images, either experimentally or clinically, thin bony walls placed between water and air or fat tend to disappear, and that bony walls tend to appear thicker than their true thickenss.departmental bulletin pape
Scintigraphic assessment of bone status at one year following hip resurfacing : comparison of two surgical approaches using SPECT-CT scan
No full textObjectives: To study the vascularity and bone metabolism of the femoral head/neck following hip resurfacing arthroplasty, and to use these results to compare the posterior and the trochanteric-flip approaches.
Methods: In our previous work, we reported changes to intra-operative blood flow during hip resurfacing arthroplasty comparing two surgical approaches. In this study, we report the vascularity and the metabolic bone function in the proximal femur in these same patients at one year after the surgery. Vascularity and bone function was assessed using scintigraphic techniques. Of the 13 patients who agreed to take part, eight had their arthroplasty through a posterior approach and five through a trochanteric-flip approach.
Results: One year after surgery, we found no difference in the vascularity (vascular phase) and metabolic bone function (delayed phase) at the junction of the femoral head/neck between the two groups of patients. Higher radiopharmaceutical uptake was found in the region of the greater trochanter in the trochanteric-flip group, related to the healing osteotomy.
Conclusions: Our findings using scintigraphic techniques suggest that the greater intra-operative reduction in blood flow to the junction of the femoral head/neck, which is seen with the posterior approach compared with trochanteric flip, does not result in any difference in vascularity or metabolic bone function one year after surgery
Supplemental Material - The importance of SNOMED CT concept specificity in healthcare analytics
No full textSupplemental Material for The importance of SNOMED CT concept specificity in healthcare analytics by Luke Roberts, Sadie Lanes, Oliver Peatman, and Phil Assheton in Health Information Management Journal</p
68Ga-PSMA PET/CT better characterises localised prostate cancer after MRI and transperineal prostate biopsy: Is 68Ga-PSMA PET/CT guided biopsy the future?
No full textBackground: 68Ga prostate specific membrane antigen PET/CT (68Ga-PSMA PET/CT) may be superior to multiparametric MRI (mpMRI) for localisation of prostate cancer tumour foci, however the concordance and differences between 68Ga-PSMA PET/CT and mpMRI when applied to all biopsied patients and potential benefit in patients with negative mpMRI is unclear. Methods: Retrospective analysis of patients undergoing mpMRI, prostate biopsy and 68Ga-PSMA PET/CT over a 3-year period. Diagnostic performance of 68Ga-PSMA PET/CT and mpMRI were assessed using biopsy histopathology for the entire cohort and radical prostatectomy specimen in a subset of patients. Lesion concordance and additional detection of each modality were determined, including in a dedicated cohort of patients with mpMRI PIRADS 2 scans. Results: A total of 144 patients were included in the study. Index lesion/foci detection was similar between 68Ga-PSMA PET/CT and mpMRI (sensitivity 83.1% vs 90.1%; p = 0.267), however lesions missed by mpMRI were larger (1.66\ua0cm vs 0.72\ua0cm; p = 0.034). Lesion detection rates were similar across the biopsy histopathology and radical prostatectomy specimen subset, with a high concordance for index (80.1%) and a moderate concordance for total (67%) lesions between the 2 imaging modalities. The additional detection yield favoured 68Ga-PSMA PET/CT over mpMRI for index (13.5% vs 4.3%) and total (18.2% vs 5.4%) lesions; both modalities missed 2.1% and 12.3% of index and total lesions, respectively. 68Ga-PSMA PET/CT identified 9 of 11 patients with PIRADS 2 mpMRI but subsequently diagnosed with Gleason ≥ 3 + 4 disease. Conclusions: Despite high concordance rates, 68Ga-PSMA PET/CT incrementally improved tumour localisation compared with mpMRI. These results suggest that 68Ga-PSMA PET/CT may have an incremental value to that of mpMRI in the diagnostic process for prostate
Jim Purkey and Jan Purkey v. Kent Max Roberts and Jilene Roberts : Brief of Appellant
No full textIN THE UTAH COURT OF APPEALS JIM PURKEY AND JAN PURKEY, Plaintiffs, v. KENT MAX ROBERTS AND JILENE ROBERTS*, Defendants/Cross-Claimants/ Appellant, v. DR. ROGER RUSSELL,* Cross-Defendant/Appellee. * - Parties on Appeal CaseNo.:20110365-CA Dist. Ct. Case No.: 070600015 BRIEF OF APPELLANT Appeal from a Final Judgment and an Order Denying Motion to Alter or Amend the Judgment of the Sixth Judicial District Court in and for Sanpete County, The Honorable Marvin D. Bagley Presiding Jerry D. Reynolds 230 N. 350 E. Orem,UT 84057 Attorney for Appellee Michael E. Day (7843) Nathan Whittaker (11978) DAY SHELL & LILJENQUIST, L.C. 45 E. Vine St. Murray, UT 84107 Attorneys for Appellan
Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene.
No full textStimulation by platelet-derived growth factor (PDGF) is known to increase the number of IGF-I binding sites in cells in culture. We show here that PDGF also increases the levels of IGF-1 receptor mRNA. Using cell lines stably transfected with an expression plasmid in which the reporter luciferase gene is under the control of the rat IGF-1 receptor gene promoter, we find that PDGF increases the activity of this promoter. A short IGF-1 receptor gene promoter, comprising about 100 base pairs of the sequence immediately upstream of the initiation of transcription site, is sufficient for a response to the stimulatory action of PDGF. These results suggest that an increase in RNA levels and in promoter activity may play an important role in the increase in IGF-1 receptor levels that occurs after stimulation by PDGF
Nucleotide sequence of a genomic fragment of the rat IGF-I gene spanning an alternate 5' non coding exon
No full textAn approach to increasing the resolution of industrial CT images based on an aperture collimator
No full textThe spatial resolution of CT images is dominated by the focal spot size when it is large relative to the detector cells. We propose an approach to increase the spatial resolution by utilizing an aperture collimator. The aperture collimator is specially designed and placed in front of the X-ray source so that the rays penetrating the collimator form a set of narrow fan beams. Then an iterative algorithm is introduced to reconstruct CT images from the data obtained by scanning the narrow fan beams. Numerical experiments show that the proposed approach could significantly increase the resolution of the CT images. Furthermore, this approach is also robust against some challenging cases, such as the examination of low contrast object, reconstruction based on multi-energy data and perturbation of geometric errors in CT systems. (C) 2013 Optical Society of AmericaOpticsSCI(E)EI1ARTICLE2327946-279632
JimPurkey and Jan Purkey v. Kent Max Roberts and Jilene Roberts : Reply Brief
No full textIN THE UTAH COURT OF APPEALS JIM PURKEY AND JAN PURKEY, Plaintiffs, v. KENT MAX ROBERTS AND JILENE ROBERTS*, Defendants/Cross-Claimants/ Appellant, V. DR. ROGER RUSSELL,* Cross-Defendant/Appellee. * - Parties on Appeal CaseNo.:20110365-CA Dist. Ct. Case No.: 070600015 APPELLANT\u27S REPLY BRIEF Appeal from a Final Judgment and an Order denying Motion to Alter or Amend the Judgment of the Sixth Judicial District Court in and for Sanpete County, The Honorable Marvin D. Bagley Presiding Charles W. Hanna (1326) LAW OFFICES OF CHARLES W. HANNA 50 W. Canyon Crest Rd. Alpine, UT 84004 Attorney for Appellee Michael E. Day (7843) Nathan Whittaker (11978) DAY SHELL & LILJENQUIST, L.C. 45 E. Vine St. Murray, UT 84107 Attorneys for Appellant ORAL ARGUMENT REQUESTED FILED UTAH APPELLATE COURT
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