3,240 research outputs found
The metabolism and pharmacokinetics of cyclohexylamine and their relevance to testicular toxicity
No full textPrevious studies have shown that chronic administration of cyclohexylamine at dose levels greater than 200mg/kg/day result in testicular atrophy in rats but not mice. The species specificity could arise from differences in metabolism, pharmacokinetics or target organ sensitivity. The metabolism of [14C]cyclohexylamine showed a marked species difference over a wide range of doses. Male Wistar rats eliminated approximately 20% of the dose as 3- and 4-aminocyclohexanols, whilst male CD1 mice excreted negligible amounts of the hydroxylated metabolites. The DA strain of rat excreted low levels of aminocyclohexanols (5% of dose). This pattern of metabolism was confirmed throughout a combined metabolism and toxicity study in which Wistar and DA rats and mice were given a toxic dose of cyclohexylamine (400mg/kg/day given as the hydrochloride) for 13 weeks. The aminocyclohexanols were detected consistently in the plasma and testes of the Wistar rats but not in the mice of DA rats. The formation of these metabolites did not correlate with testicular effects since atrophy was found in both strains of rats, but not in mice. In vitro studies using the rat anococcygeus muscle showed that cyclohexylamine was about ten times more potent than the hydroxylated metabolites as an indirect sympathomimetic compound. Dose-dependent increases in the terminal half-life and time to peak concentration were found in male rats following a single oral dose of [14C]cyclohexylamine. This was associated with a decrease in plasma clearance. In vivo and in vitro studies indicated saturable active renal tubular secretion of cyclohexylamine in the rat. The plasma clearance in the mouse was about twice that in the rat and the pharmacokinetics did not show clear evidence of dose-dependency over the range studied. Chronic ad libitum administration of cyclohexylamine in the diet (0-0.9% cyclohexylamine given as the hydrochloride) was associated with a non-linear relationship between the concentration in plasma or testes and the daily intake in rats, but not in mice. The non-linearity in rats was apparent at doses greater than 200mg/kg/day, which corresponds to the steep increase in the dose response for testicular atrophy in this species. Intakes of approximately 750mg/kg/day were necessary in mice to produce plasma and testes concentrations of cyclohexylamine similar to those found in rats fed a clearly toxic dose (300mg/kg/day). Thus, inter-species and dose-dependent differences in pharmacokinetics may contribute to the species differences and dose response relationship for cyclohexylamine induced testicular toxicity.</p
Dr. Ashley Austin - Faculty Author Interview
No full textDr. Ashley Austin, Assistant Professor of Accounting, discusses a recent article in Contemporary Accounting Research, entitled “Improving Auditors’ Consideration of Evidence Contradicting Management’s Estimate Assumptions.” Dr. Austin’s research interests involve using experimental methods to understand and improve auditors’ judgments and decision making, with a focus on how to motivate auditors to exercise professional skepticism and be alert to fraud throughout the audit
Ashley B. Living Memoirs Interview
No full textAshley B., an alumnus of Southern Adventist University, shared about her interesting time serving as a business student missionary for Akuna Soaps Industries in the Southern Province of Zambia. She shared about her business background and how this impacted her time serving as well as how her missionary year impacted her career goals.
Zambia is a land-locked country in south-central Africa located on a high plateau. The most commonly spoken languages include the Bantu languages of the Niger-Congo language family, but English is the official language of the government and is used for education, commerce, and law. Zambia is known for one-third of the country being national parks and for containing Victoria Falls.
Williams, Geoffrey J. , Hobson, Richard Hamilton and Roberts, Andrew D.. Zambia . Encyclopedia Britannica, 2 Nov. 2023, https://www.britannica.com/place/Zambia. Accessed 2 November 2023.
Views expressed do not represent Southern Adventist University or McKee Library but are the personal opinions of the interviewed individual
Austin Papers: Series III, 1829
No full textCopy of transcript for a letter from William F. Roberts to Stephen F. Austin requesting Austin draft an order to Chester Ashley, so Roberts can collect Ashley's debt to him and Austin
Marriage record of Ashley, Thomas and Wood, Daisy
No full textMarriage license for Thomas Ashley and Daisy Wood. R. Roberts was the officiant
Data Set of Psychiatry Journal Author Guidelines for Case Reports
No full textData set for psychiatry journal author guidelines for case report
Pohli, Ashley #002
No full textApril Miller (left) and Karen Roberts (right) on the day they signed their marriage license issued by Deputy Clerk Brian Mason.https://scholarworks.moreheadstate.edu/marriage_equality_images/1180/thumbnail.jp
Ashley Judd and Candelaria Silva discuss, Bittersweet Humanitarianism at Ford Hall Forum, video recording, 4/8/2011
No full textAshley Judd, award-winning actress, humanitarian, and author of All That Is Bitter and Sweet joins moderator Candelaria Silva, author and Roxbury Film Festival founder, to discuss Judd\u27s experiences in feminist social justice work to discover the relationship between healing oneself and healing others.https://dc.suffolk.edu/fhf-av/1107/thumbnail.jp
Of Tales, tragic opera, transformation and “tongues”: Tristan und Isolde in Angela Carter’s The Bloody Chamber
No full textThis chapter explores a hitherto under-researched aspect of Angela Carter’s writings: her subversive incorporation of Wagner’s opera, Tristan und Isolde, into her seminal Bloody Chamber collection. Indeed, Carter uses (and abuses) the Tristan motif to critically examine art and myth, deconstruct fixed binaries and reconfigure tired archetypes as hybrid figures that defy boundaries and challenge culturally inculcated beliefs about gender relations, eroticism, and art.
These moves, coupled with the performative nature of both Wagner’s opera and Carter’s tales, also anticipate current trends in feminist and queer theory, thereby guaranteeing the continued relevance of the collection for the twenty-first century. This initial study of Carter’s critical dialogue with Wagner’s Tristan demonstrates the important role played by Tristan und Isolde in Carter’s “demythologizing” use of fairy tale and her feminist project in The Bloody Chamber
FIGURES 1–2. Prosorhynchoides thomasi n in Exploiting mimicry: Prosorhynchoides thomasi n. sp. (Digenea: Bucephalidae) from the fang blenny genus Plagiotremus (Bleeker) (Blenniidae) from off Lizard Island on the Great Barrier Reef, Australia
No full textFIGURES 1–2. Prosorhynchoides thomasi n. sp. 1. Ventral view of holotype from Plagiotremus tapeinosoma. 2. Cirrus-sac, ventral view. Scale bars 1, 200µm; 2, 100µm.Published as part of Bott, Ashley Roberts-Thomson Nathan J., 2007, Exploiting mimicry: Prosorhynchoides thomasi n. sp. (Digenea: Bucephalidae) from the fang blenny genus Plagiotremus (Bleeker) (Blenniidae) from off Lizard Island on the Great Barrier Reef, Australia, pp. 61-64 in Zootaxa 1514 on page 62, DOI: 10.5281/zenodo.17727
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