1,721,092 research outputs found
Introduzione alla nutraceutica, stato dell'arte della ricerca scientifica in tale ambito e risvolti sulla salute
No full textNutraceutica tra alimentazione e farmaceutica: valutazione biologica di estratti naturali
No full textRoberta Budriesi, Entroterra « ravennate » e orizzonti barbarici. Matrici e uomini nuovi nei monumenti delle alte valli dal Lamone al Savio
No full textFailler Albert. Roberta Budriesi, Entroterra « ravennate » e orizzonti barbarici. Matrici e uomini nuovi nei monumenti delle alte valli dal Lamone al Savio . In: Revue des études byzantines, tome 44, 1986. p. 301
APPLICAZIONE SULLA DISMOTILITÀ INTESTINALE DI ESTRATTI DI FOGLIE DI OLEA EUROPAEA L. E DI PETALI DI HIBISCUS SABDARIFFA L. (HERBAL MIX)
No full textRazionale dello studio: La miscela di erbe (Herbal Mix, HM)
composta da estratti di foglie di Olea europaea L. ed estratti di
petali di Hibiscus sabdariffa L. è stata studiata su alcuni target di
patologie infiammatorie intestinali caratterizzate da dismotilità.
Nello specifico, ne sono stati analizzati gli effetti sulla contrattilità
della muscolatura liscia intestinale e l’azione su iNOS ed eNOS
umana.
Materiali e Metodi: HM è costituito dall’86,67% di estratto
di foglie di Olea europaea L. (principalmente oleuropeina) e dal
13,33% di estratto di fiori di Hibiscus sabdariffa L. (principalmente
acido ibiscico), in rapporto 13:2. Sono stati utilizzati tessuti ex
vivo di ileo e colon per l’analisi degli effetti di HM sulla contrattilità
spontanea e indotta; per la valutazione dell’inibizione della
NOS, è stato seguito il saggio della L-citrullina con rilevamento
fluorimetrico.
Risultati: HM ha mostrato attività spasmolitica con significativa
diminuzione delle contrazioni ad alta e media frequenza su ileo
e colon, sia per quanto riguarda la contrattilità spontanea che
indotta, con un effetto di tipo dose-dipendente. Inoltre, l’estratto
ha provocato un’inibizione dose-dipendente degli enzimi iNOS
ed eNOS, con un effetto massimo del 67% per iNOS e del 64%
per eNOS.
Conclusioni: I risultati mostrano che HM costituisce una formulazione
efficace nella modulazione di alcuni bersagli legati alle
malattie intestinali su base infiammatoria
Hibiscus flowers and olive Leaves extracts-based formulation in neurodegeneration: a network-based approach
No full textNutraceuticals in Gastrointestinal ailments : an emerging paradigm
No full textInflammatory bowel disease (IBD) is a chronic gastrointestinal disorder, of multifactorial origin.
The pathogenetic mechanisms consist of immune dysregulation, altered intestinal microflora, oxidative stress, defects in the gastrointestinal mucosal barrier and increased permeability, altered intestinal motility, whose interplay leads to the onset of a state of chronic mucosal inflammation.1
The drugs for IBD treatment include corticosteroids, immunosuppressants, and anti-tumor necrosis factor (TNF)-α antibodies, and new therapeutic molecules, that increase the risk of opportunistic infections and malignancies. Furthermore, their efficacy decreases over time and highlights the need to identify new molecular targets for IBD therapy .1
Scientific Research aims at identifying tools able to affect several targets, with minimal side effects.
Nutraceutical identifies foods, or food phytochemicals, of animal or vegetal origin, with pharmaceutical properties.
Many vegetal extracts determine several effects towards the gastrointestinal tract, which may result in clinical benefits in subjects suffering from IBD.2
Castanea sativa Mill. bark extract (ENC), containing high amounts of hydrolizable tannins (Fig. 1), inhibits spasmodic contractions, induced by carbachol, histamine, potassium chloride, and barium chloride in guinea pig ileum and by carbachol or serotonin in guinea pig proximal colon.3 Furthermore, ENC increases gallbladder contraction and relaxes the sphincter of Oddi, suggesting its chronic administration may result not only in a restoration of gastrointestinal contractility, but also in the prevention of gallstone disease. 4
Also Acacia catechu Willd. extract (ACE) was investigated.5
ACE contains high amounts of catechins, such as (-)-Epicatechin and (+)-Catechin. This extract decreases, in a concentration-dependent manner, colon and ileum spontaneous contractility. In addition, ACE exerts a calcium antagonistic effect, more potent in proximal colon than in ileum. Furthermore, it exhibits antimicrobial effects against Campylobacter jejuni, Escherichia coli, and Salmonella spp., without inhibiting Bifido and Lactobacillus.
These data support the use of ENC and ACE as coadjuvant in the treatment of IBD
Waste by-products from Olea europaea as a potential application in Inflammatory Bowel Syndrome
Full text linkThe use of agri-food by-products represents an important resource in the nutraceutical field in a circular economy perspective oriented to the valorization of our territory products: among these, the olive tree (Olea europaea, Coratina cultivar in particular), is an excellent nutraceutical even though it derives from food waste. In this study we present a polyphenolic complex - derived from the mechanical filtration process of wastewater resulting from olive oil production - called MOMAST®. Based on the results obtained from the chemical composition analysis, we hypothesized a possible application of the phytocomplex as a food supplement in Irritable Bowel Syndrome (IBS) [1] [2]. After testing three different types of extracts (MOMAST Plus30, PW25, and HY100) on some IBS-related targets, we verified their antioxidant action and effects on spontaneous and induced intestinal contractility of ileum and colon [3, 4]. From the scientific evidence found, MOMAST® compounds have proved to be excellent candidates to become food supplements in the treatment of IBS [5]: in particular, Plus30 also showed an interesting action against some microorganisms due to its high concentration of polyphenols and oleuropein.
References
[1] L. Recinella, A. Chiavaroli, G. Orlando, L. Menghini, C. Ferrante, L. Di Cesare Mannelli, C. Ghelardini, L. Brunetti, S. Leone, Molecules, 2019, 24, 3002.
[2] T. Tian, Z. Wang, J. Zhang, Oxidative Medicine and Cellular Longevity, 2017, 2017, 4535194.
[3] J.K. Triantafillidis, A. Triantafyllidi, C. Vagianos, A. Papalois, Annals of Gastroenterology, 2016, 29, 268.
[4] M. Micucci, M. Malaguti, T.G. Toschi, G. Di Lecce, R. Aldini, A. Angeletti, A. Chiarini, R. Budriesi, S. Hrelia, Oxidative Medicine and Cellular Longevity, 2015, 2015, 318125.
[5] M.J. Oliveras-López, G. Berna, E.M. Carneiro, H.L.G. De La Serrana, F. Martin, M.C. López, The Journal of Nutrition, 2008, 138, 1074
Polifenoli delle acque reflue di vegetazione e attività biologica: focus sulla sindrome dell'intestino irritabile (IBS)
No full textFrom natural products based research, n ew substances for the treatment of Candida sp infections: the case of spirulina platensis
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