232 research outputs found

    Correction to: RarERN Path: a methodology towards the optimisation of patients’ care pathways in rare and complex diseases developed within the European Reference Networks (Orphanet Journal of Rare Diseases, (2020), 15, 1, (347), 10.1186/s13023-020-01631-1)

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    Following the publication of the original article [1] we were informed that the authors’ given and family names had unfortunately been interchanged. The correct author names are shown here below: Rosaria Talarico, Sara Cannizzo, Valentina Lorenzoni, Diana Marinello, Ilaria Palla, Salvatore Pirri, Simone Ticciati, Leopoldo Trieste, Isotta Triulzi, Enrique Terol, Anna Bucher and Giuseppe Turchetti. The author names have been corrected in the author list of this Correction and updated in the original article

    From James Joyce to Katherine Mansfield: Epiphanic Poetics and Writing of the Self

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    With the term and notion of epiphany Joyce created not only what was to become a fundamental tool for the interpretation of his own work. He gave a name to – thus contributing to make visible – an issue which, to a large extent, characterised all modernist poetics and which determined the restless formal experimentation of the period. In this essay, I analyse some aspects of Katherine Mansfield’s reflection on the epiphanic moment, which she calls “glimpse”. My aim is twofold: on the one hand, I wish to highlight the original stance of this major and highly innovative author, whose deep theoretical awareness has long been undervalued; on the other hand, I intend to provide material for further critical investigation on the affinity and difference between Mansfield and Joyce on the notion of epiphany, thereby contributing to the general critical debate on the aesthetics which developed during the first decades of the twentieth century

    On the canonization of Edward III

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    In recent decades, the apocryphal play Edward III has undergone a process of canonization: after Giorgio Melchiori’s fundamental edition for the New Cambridge Shakespeare (1998) and its inclusion both in the second edition of The Oxford Shakespeare (2005) and in The New Oxford Shakespeare (2016), the recent publication of the long-announced edition, by Richard Proudfoot and Nicola Bennett, for the Arden Shakespeare Third Series (2017) seems to ratify the definitive admission of the play to the Shakespeare canon. This process, however, has taken place in the context of heated debates over the notions of ‘canon’ and 'author’ which render the concept itself of ‘canonization’ problematic. Taking its cue from the recent Arden edition, this essay aims to review some key moments in the publication history of Edward III and to highlight the peculiarities that make its Shakespearean attribution a unique case study worthy of further critical scrutiny

    Financial Statement Valuations in Italy: The Contribution of Fabio Besta (1845-1922)

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    Fabio Besta (1845-1922) is widely recognized as one of the founding fathers of Italian accounting theory and as a prominent figure at an international level. Among his most significant contributions, his theorization on the topic of financial statement valuations stands out, characterised by a notable degree of originality. Although starting from the economic studies of the time on the theory of value, Besta elaborates a framework consistent with his conception of accounting as a “science of economic control”. This paper aims to analyse this contribution, going beyond simple historical reconstruction to delve into how the author addressed the complex problem of choosing between different valuation bases. Particular attention is paid to the comparison between the criterion of exchange value and the criterion of cost, a debate that still retains great relevance. Understanding the historical origins of these approaches allows us to interpret contemporary accounting choices with greater awareness, bringing out the theoretical and practical roots of still-open questions

    Teleological versus Non-Teleological Perspectives in Financial Statement: The Debate between Chambers and Onida

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    The paper examines the scientific debate that took place in 1973 in the journal Rivista dei Dottori Commercialisti (Italian Journal of Chartered Accountants) between Pietro Onida and Raymond J. Chambers concerning the nature of financial statement information. Our research revealed that Onida was the advocate of a teleological theory of the financial statement, whereas Chambers supported the perfect neutrality of accounting information. Going back to theoretical precedents, the thoughts of the two scholars have different ontological and epistemological assumptions. If, ontologically, Chambers conceives reality as unique and objective, being inspired by the neopositivism of the ‘‘received view,’’ Onida admits the existence of multiple realities by adopting an interpretivist perspective. Epistemologically, the Australian scholar approaches accounting as a pure science by leveraging its deductive moment rather than empirical recognition, whereas the Italian author conceives accounting as an ‘‘application science’’ and adopts a method where the inductive approach prevails

    Punitive Damages and the Processing of Tort Claims

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    Punitive damages are one of the most controversial aspects of tort litigation and have been the subject of various theoretical, empirical, and experimental studies. One criticism of punitive damages refers to the effect that they have on civil litigation processes. In particular, Polinsky (1997) argues that the uncertainty and unpredictability that punitive damage claims inject into a case may increase both the rate and amount of settlements, thus implying that punitive damages carry systemic consequences for the general processing of tort claims. This paper represents the first, empirical examination of this implication. With one of the largest and most comprehensive data sets of tort litigation (over 25,000 cases filed from 1994 through 1997 in several counties in Georgia), we examine the effect of the decision to seek punitive damages on several major decision points in the tort litigation process in a series of logit regression models. With extensive control variables for type of case, the presence or absence of caps on damages, and other potentially important variables, we find that seeking punitive damages has no statistically significant effect on most phases of the tort litigation process.Torts, Litigation, Punitive Damages, Settlement Rates

    sj-docx-1-cpa-10.1177_07067437221099774 - Supplemental material for Suicide and Self-Harm Among Physicians in Ontario, Canada

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    Supplemental material, sj-docx-1-cpa-10.1177_07067437221099774 for Suicide and Self-Harm Among Physicians in Ontario, Canada by Manish M. Sood, Emily Rhodes, Robert Talarico, Caroline Gérin-Lajoie, Christopher Simon, Edward Spilg, Taylor McFadden, Kwadwo Kyeeremanteng, Daniel T. Myran, Nicholas Grubic and Peter Tanuseputro in The Canadian Journal of Psychiatry</p

    Synthesis and Biological Evaluation of D- and L- Cyclohexenyl Nucleosides

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    Cyclohexenyl nucleosides (Figure 1) represent well-known biomimetic agents, working as bioactive nucleoside analogues, either at monomeric and oligomeric level,1 or as substrates/templates for enzymatic replication.2 These properties are due to the capacity by the cyclohexenyl ring to act as a conformational bioisostere of natural deoxyribose. Herein, the asymmetric synthesis of 2 and ent-2 (B = Pu or Py) starting from achiral cyclohexanone is reported (Figure 2). Main attention has been devoted to the key Tsuji-Trost rearrangement step of 3 and ent-3, whose unprecedented stereoconvergent outcome has been studied by chemical methods, as well as, by spectroscopic and in silico analysis. Preliminary in vitro assays against a variety of HHV infections are also presented, revealing interesting antiviral properties, especially against TK- strain

    Synthesis and antiviral properties of biomimetic iminosugar-based nucleosides

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    Herein we report the synthesis, conformational analysis and the evaluation of the antiviral activity of six-membered nucleoside analogues having a piperidine ring as the preorganized (deoxy)ribose bioisostere. Mutagenic nucleobase-containing nucleosides 1 and 2 were obtained by appropriate manipulation of the well-known glycomimetic agent deoxynojirimycin as easily accessible starting material. In vitro assays revealed activity of 5-iododeoxyuridine analogue 1 against all DNA viruses tested. As suggested by DFT analysis and pH-dependent NMR experiments, antiviral activity was correlated to the biomimetic character of the piperidine ring, as it is able to resemble the deoxyribose conformations adopted by natural nucleosides when interacting with viral enzymes.sponsorship: This work was funded by University of Naples Federico II in the frame of an international agreement with Katholieke Universiteit Leuven (biennium 2017-2018). (University of Naples Federico II, Katholieke Universiteit Leuven)status: Publishe
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