4 research outputs found
Early use of mammalian target of rapamycin inhibitors is an independent risk factor for incisional hernia development after liver transplantation.
No full textIncisional hernias (IHs) are common complications after liver transplantation (LT) with a reported incidence of 1.7\% to 34.3\%. The purpose of this retrospective study was to evaluate the risk factors for IH development after LT with a focus on the role of immunosuppressive therapy during the first month after LT. We analyzed 373 patients who underwent LT and divided them into 2 groups according to their postoperative course: an IH group (121 patients or 32.4\%) and a no-IH group (252 patients or 67.6\%). A univariate analysis demonstrated that the following were risk factors related to IH development: male sex (P = 0.03), a body mass index ≥ 29 kg/m(2) (P = 0.005), LT after 2004 (P = 0.02), a Model for End-Stage Liver Disease (MELD) score ≥ 22 (P = 0.01), and hepatitis B virus infection (P = 0.01). The highest incidence of IHs was found in patients treated with mammalian target of rapamycin (mTOR) inhibitors (54.5\%, P = 0.004). A multivariate analysis revealed male sex (P = 0.03), a pretransplant MELD score ≥ 22 (P = 0.04), and the use of mTOR inhibitors (P = 0.001) to be independent risk factors for IHs after LT. In conclusion, immunosuppressive therapy with mTOR inhibitors is an important independent risk factor for IH development after LT. To reduce the incidence of IHs, mTOR inhibitors should be avoided until the fourth month after LT unless their use is deemed to be strictly necessary
The impact of the economic crisis on media framing : evidence from three elections in Ireland
No full textMedia coverage of elections in Europe and North America has increasingly focused on the campaign as a game rather than a policy debate. This is often explained by the changes in media pressures. It may also reflect the narrowing of policy space between left and right and the comparative prosperity enjoyed in Europe and North America. But the relevance of politics varies. The global economic crisis might have led to an increased interest in policy among voters and focus on it by media. Ireland experienced both extremes of boom and crisis between the late 1990s and 2011. The Irish case allows us to test the impact of the crisis on media framing of elections. This article uses original data from the three most recent national elections in Ireland, with a research design that holds other pertinent variables constant. We find empirical support for the theoretical expectation that the context of the election affects the relative focus on campaign or horserace versus substantive policy issues
In, out and after care: Young adults' views on their lives, as children, in a therapeutic residential establishment
No full textChildren who have been severely maltreated may be placed in therapeutic children's homes (also known as residential treatment centres) in order that their often acute emotional and behavioural needs can be addressed. There is little data on process within these settings, especially outside the US. This article contains findings from interviews carried out with 16 young adults who had been placed in a therapeutic children's home in England. These former residents were asked for their views concerning the care they had received. The respondents were, in general, positive about their experiences, particularly in terms of their relationships with staff, life story work, leisure activities and the contact they had with staff after leaving the homes. Some of them were also happy with their experiences in relation to therapy, school, friendships and preparations for leaving the placement but others were less contented in these respects. The evidence from this research is that this highly disadvantaged group of children can be provided with a good quality of care within therapeutic children's homes
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Effects of organisational policies and practices on job satisfaction among employees of international non-governmental organisations (INGOs)
No full textSince International Non-Governmental Organisations (INGOs) gained United Nations’ recognition in the 1950s, they have continued to grow in stature as key global players. Consequently, a lot of research attention has been devoted to the global influence of INGOs and the management challenges that they face. Despite steady increase in the number of research publications that focus on a wide range of INGO issues, employee job satisfaction has yet to receive serious research attention. This study seeks to fill that gap by examining forms and levels of job satisfaction among INGO employees in the United Kingdom and Africa. The study explores the influence of INGO mission, culture, structure and HRM policies and practices on employee job satisfaction. The questions addressed in this research focus on how employees perceive their jobs and the performance of INGOs in executing corporate missions, application of principles and values, working relations between headquarters and field locations and HRM policies and practices. Data collection involved 35 in-depth interviews with employees in various INGOs in the UK and Africa. The secondary method for data collection is questionnaire administration. Findings from this research contribute to what is currently known about job satisfaction in the INGO sector. Interpreting accounts of work experiences through dialectical mechanisms represents a unique and dynamic approach to the study of job satisfaction. Furthermore, the finding that effective application of corporate principles and values remains a critical factor as far as job satisfaction among INGO employees is concerned challenges the thinking that ‘corporatisation’ and ‘professionalization’ have robbed the sector of its values
