5,853 research outputs found
Revealed likelihood and knightian uncertainty
No full textexpected utility theory;uncertainty;revealed preference
Metabolitos secundarios de raiz de Chromolaena leivensis (Hieron) King y H. Rob.
No full text98 páginas : ilustraciones, gráficasEl estudio se basó en la Identificación de metabolitos secundarios presentes en la raíz de la especie colombiana Chromolaena leivensis (Hieron) King & H. Rob. Para lo cual se realizó un extracto total etanolico en equipo Soxhlet. Dicho extracto fue fraccionado por percolación con solventes de polaridad creciente desde (éter de petróleo, diclorometano y metanol). La fracción éter de petróleo se eluye por cromatografía en columna (CC) con mezclas de polaridad creciente (pretrol, petrol:diclorometano 9:1; 8:2, diclorometano, hasta metanol), las subfracciones menos complejas fueron evaluadas por CG-EM y comparando con las bases de datos Nist-08 y Willey-8. Se identificaron compuestos como: 6,10,14-trimetil-2-pentadecanona, acido-ascórbico-2,6-dihexadecanoato, 1-docosanol, 1-Heptacosanol, friedeoolean-3-ol, 1-pentacosanol, vainillina, 2,2´-isopropilidenedifurano, Cholest-7-en-3-ol, Cholest-4-en-3-ona, Heneicosano, Hexatriacontano, Acido-mono(etil-hexil)-1,2-bencendicarboxilico, Friedelan-3-ona, 1-nonadecanol, tetracosanol, acido-mono(2-etil-hexil)-1,2-bencenedicarboxilico, Friedelanol, 5,7-dihidroxi-flavanonaIncluye bibliografíaPregradoQuímico(a
Prisoners’ gang-related activity: the importance of bullying and moral disengagement
No full textGang-related activity can have a significant impact on the effective management of prisons in the UK, yet little is known about the characteristics of the prisoners involved. I it this study, 141 adult male prisoners' gang-related activity was examined in relation to their bullying behaviour and use of moral disengagement. Results showed that prisoners most involved in gang-related activity were likely to have spent a longer total time in the prison system, be perpetrators of bullying and have high levels of moral disengagement. Findings also show that moral disengagement partially mediates the relationship between bullying and gang-related activity Implications for treatment programmes and the prison estate are discussed
Determinación de las condiciones óptimas de extracción de compuestos antioxidantes de hojas de vernonanthura patens (kunth) h. rob
No full textVernonanthura patens (Kunth) H. Rob., o laritaco es un arbusto silvestre que crece en varias provincias del Ecuador. Los conocimientos ancestrales indican que la cocción de las hojas ha sido empleada en la medicina tradicional para curar diferentes enfermedades. Varios estudios han reportado que los extractos acuosos y etanólicos obtenidos de las hojas de la especie exhiben una alta actividad antioxidante. Sin embargo, no se conocen las condiciones óptimas de extracción ni los compuestos responsables de esta actividad biológica. Por lo tanto, en el presente estudio se planteó como objetivo general determinar las condiciones óptimas de extracción de los compuestos antioxidantes de hojas de Vernonanthura patens (Kunth) H. Rob.GuayaquilMagister en Biociencias Aplicadas con mención en Biodescubrimiento
Transforming growth factor beta(1) selectively regulates ferritin gene expression in malignant H-ras-transformed fibrosarcoma cell lines
No full textTransforming growth factor beta(1) is an important growth regulator in many cell types, usually exerting a negative effect on cellular growth. Inhibition of DNA synthesis and cell proliferation is frequently lost during malignant transformation, and in some cases, tumor cell proliferation is actually stimulated by TGF-beta(1). The present study demonstrates a novel link between alterations in TGF-beta(1), regulation during malignant conversion, and the expression of ferritin, an important activity involved in a number of biological functions including iron homeostasis and cell-growth control. A series of H-ras-transformed mouse 10 T 1/2 cell lines, exhibiting increasing malignant potential, was investigated for possible TGF-beta(1)-mediated changes in ferritin gene expression. Selective induction of gene expression was observed, since only H-ras-transformed cells with malignant potential exhibited marked elevations in ferritin gene expression, in particular, alterations in H-ferritin gene expression. The regulation of H-ferritin gene expression in response to TGF-beta(1) did not involve alterations in transcription, but occurred through mechanisms of post-transcriptional stabilization of the H-ferritin mRNA. Additionally, evidence was obtained for a cycloheximide-sensitive regulator of H-ferritin gene expression, since the presence of this protein synthesis inhibitor increased H-ferritin message levels, and in combination with TGF-beta(1), cooperated in an additive manner to augment H-ferritin gene expression. These results show for the first time that TGF-beta(1) can regulate ferritin gene expression in malignant H-ras transformed cells, and suggest a mechanism for growth factor stimulation of malignant cells, in which early alterations in the control of H-ferritin gene expression are important.PT: J; CR: AMARA FM, 1993, NUCLEIC ACIDS RES, V21, P4803 AMARA FM, 1994, J BIOL CHEM, V269, P6707 CHOY BK, 1989, BIOCHEM BIOPH RES CO, V162, P1412 DESHPANDE VV, 1985, J BIOL CHEM, V260, P757 EDWARDS DR, 1992, EMBO J, V11, P2415 EGAN SE, 1987, MOL CELL BIOL, V7, P830 EGAN SE, 1987, SCIENCE, V238, P202 EGAN SE, 1988, CELLULAR MOL BIOL TU, P279 GONZALEZ IL, 1985, P NATL ACAD SCI USA, V82, P7666 GREENBERG AH, 1989, INVAS METAST, V9, P360 HURTA RAR, 1990, BIOCHIM BIOPHYS ACTA, V1087, P165 HURTA RAR, 1991, BIOCHEM CELL BIOL, V69, P635 HURTA RAR, 1991, J BIOL CHEM, V266, P24097 HURTA RAR, 1992, J BIOL CHEM, V267, P7066 HURTA RAR, 1993, J CELL PHYSIOL, V156, P272 HURTA RAR, 1995, J CELL BIOCHEM, V57, P543 JAKOWLEW SB, 1988, ONCOGENE RES, V2, P135 KOHGO Y, 1980, J BIOL CHEM, V255, P5195 LEIBOLD EA, 1984, J BIOL CHEM, V259, P4327 MATTIA E, 1989, P NATL ACAD SCI USA, V86, P1801 MCCLARTY GA, 1987, BIOCHEMISTRY-US, V26, P8004 MCCLARTY GA, 1990, J BIOL CHEM, V265, P7539 MILLER LL, 1991, P NATL ACAD SCI USA, V88, P4946 MUKHERJEE R, 1987, J BIOL CHEM, V262, P13697 MURRAY MT, 1987, P NATL ACAD SCI USA, V84, P7438 NICOLSON GL, 1984, CANCER METAST REV, V3, P25 PANG JHS, 1996, BIOCHEM J 1, V319, P185 PERTOVAARA L, 1989, MOL CELL BIOL, V9, P1255 PHILLIPS DR, 1986, BIOCHEMISTRY-US, V25, P7355 RAGHOW R, 1987, TRENDS BIOCHEM SCI, V12, P358 SCHWARZ LC, 1988, CANCER RES, V48, P6999 SCHWARZ LC, 1990, GROWTH FACTORS, V3, P115 SPORN MB, 1990, CELL REGUL, V1, P875 TAMBURINI A, 1999, UNPUB TRANSFORMATION TAMM I, 1978, ADV VIRUS RES, V22, P187 THEIL EC, 1987, ANNU REV BIOCHEM, V56, P289 THELANDER L, 1980, J BIOL CHEM, V255, P7426 THOMAS CE, 1986, J BIOL CHEM, V261, P13064 WEBER G, 1983, CANCER RES, V43, P3466 WEINBERG RA, 1989, ONCOGENES MOL ORIGIN, P46 WILDER PJ, 1991, CANCER RES, V51, P5898 WRIGHT JA, 1989, INT ENCY PHARM THERA, V128, P89 WRIGHT JA, 1990, ANTICANCER RES, V10, P1247 WRIGHT JA, 1990, BIOCH CELL BIOL, V68, P1364 WRIGHT JA, 1993, CRIT REV ONCOGENESIS, V4, P473; NR: 45; TC: 1; J9: BIOCHEM CELL BIOL; PG: 9; GA: 356BNSource type: Electronic(1
Efecto antiinflamatorio del extracto hidroalcohólico de las hojas y tallos de Aristeguietia ballii (Oliv) R.M. King & H. Rob. “huamantirca hembra” y Aristeguietia discolor (DC) King & Rob. “huamantirca macho” en ratas Holtzman. Ayacucho, 2024
No full textLa inflamación es una respuesta del sistema inmunológico frente a diversos agentes dañinos y es un problema de salud que requiere alternativas terapéuticas. El estudio tuvo como objetivo evaluar el efecto antiinflamatorio del extracto hidroalcohólico dehojas y tallos de Aristeguietia ballii (Oliv) R.M. King & H. Rob. “huamantirca hembra” y Aristeguietia discolor (DC) King & Rob. “huamantirca macho”. Las muestras fueron recolectadas en el centro Poblado de Carampa y posteriormente analizadas en los laboratorios de la Escuela de Farmacia y Bioquímica. Se emplearon 40 ratas Holtzman, distribuidas en ocho grupos, con inflamación inducida mediante carragenina en la aponeurosis subplantar. El análisis fitoquímico realizado en ambos extractos evidenció la presencia de flavonoides, cumarinas, alcaloides, taninos, fenoles, saponinas, resinas y azúcares reductores. Los resultados mostraron que el extracto de “huamantirca hembra” presentó porcentajes de inflamación 79,12%; 68,04% y 52,31% a dosis de 100, 200 y 400 mg/kg, respectivamente, mientras que el “huamantirca macho” reportó 72,85%; 61,62% y 47,49%. En cuanto al porcentaje de eficiencia antiinflamatoria, el diclofenaco alcanzó 36,87%; el extracto de “huamantirca hembra” presentó 18,33%; 30,24% y 46,21% y el extracto “huamantirca macho” reportó 20,81%; 32,46% y 48,45% en las mismas dosis. Se concluye que la dosis de 400 mg/kg de “huamantirca hembra” mostró un efecto estadísticamente similar al diclofenaco 20 mg/kg, mientras que el extracto de huamantirca macho a 400 mg/kg presentó diferencia significativa frente al estándar (p<0,05), lo cual indica que ambos extractos poseen efecto antiinflamatorio.Tesi
"Maastricht 2042 and the Fate of Europe: Toward Convergence and Full Employment"
No full textUnemployment in the European Union (EU) is a serious problem that threatens to disrupt the integration of accession countries, the character of individual countries, and the continued existence of the EU. According to Senior Scholar James K. Galbraith, European integration poses a huge conundrum for European employment because the conventional theory explaining unemployment in EuropeÐlabor market rigiditiesÐis wrong. The application of this policy will not cure European unemployment, but it could destroy the economic promise of the EU for its poorer regions and the accession countries.
Efecto de la altura del corte sobre la capacidad de rebrote, crecimiento y supervivencia en Smallanthus pyramidalis (Triana) H. Rob
No full textObjetive: Analize the resprouting capacity, growth and survival after an event of removal of aerial biomass in Smallanthus pyramidalis (Triana) H. Rob., colonizing specie, potential for use in ecological restoration and silvopastoral systems of the Colombian Andes. Methods: Individuals were randomly selected in a plot of 120 m2 and two treatments were carried out (T1 and T2) with 20 replications each. In T1 the stem was cut at 50 cm from the soil and in T2 at 100 cm from the soil, and we evaluated the length of shoots, diameter and height of the stem after cutting, number of leaves, leaf area, proportion of predated leaves and percentage of survival, to compare the response of these variables against the removal of aerial biomassat different cutting heights. Results: It was observed that after one year, the sprouts reached more than 100 cm in length, foliar area of 350 cm2 and survival of individuals by treatment greater than 75%. The height of the cut is not related to the length reached by the sprouts or with the growth in diameter of thestems (p>0.005) which may imply a compromise (trade-off) with the growth of the plant, but if it is relatedto the foliar area and the number of leaves produced.Objetivo: Analizarla capacidad de rebrote, crecimiento y supervivencia después de un evento de remoción de biomasa aérea en Smallanthus pyramidalis (Triana) H. Rob., especie colonizadora, potencial para usar en restauración ecológica y en sistemas silvopastoriles de los Andes Colombianos. Metodología: se seleccionaron individuos aleatoriamente en una parcela de 120 m2y se realizaron dos tratamientos (T1 y T2) más el testigo (T3). En T1 se realizó corte del tallo a 50 cm del suelo y en T2 a 100 cm del suelo y se evaluó a lo largo de un año la longitud de rebrotes, diámetro y altura del tallo después del corte, número de hojas, área foliar, proporción de hojas depredadas y porcentaje de supervivencia, para comparar la respuesta de estas variables frente a la remoción de biomasa aérea a diferentes alturas de corte. Resultados: se observó que al año los rebrotes alcanzaron más de 100 cm de longitud, área foliar de 350 cm2y supervivencia de individuos por tratamiento mayor al 75% . La altura del corte no está relacionada con la longitud que alcanzaron los rebrotes ni con el crecimiento en diámetro de los tallos (p>0.005) lo que puede implicar un compromiso (trade-off) con el crecimiento de la planta, pero sí se relaciona con el área foliar y el número de hojas producidas
Efecto de la altura del corte sobre la capacidad de rebrote, crecimiento y supervivencia en Smallanthus pyramidalis (Triana) H. Rob
No full textObjetive: Analize the resprouting capacity, growth and survival after an event of removal of aerial biomass in Smallanthus pyramidalis (Triana) H. Rob., colonizing specie, potential for use in ecological restoration and silvopastoral systems of the Colombian Andes. Methods: Individuals were randomly selected in a plot of 120 m2 and two treatments were carried out (T1 and T2) with 20 replications each. In T1 the stem was cut at 50 cm from the soil and in T2 at 100 cm from the soil, and we evaluated the length of shoots, diameter and height of the stem after cutting, number of leaves, leaf area, proportion of predated leaves and percentage of survival, to compare the response of these variables against the removal of aerial biomass at different cutting heights. Results: It was observed that after one year, the sprouts reached more than 100 cm in length, foliar area of 350 cm2 and survival of individuals by treatment greater than 75%. The height of the cut is not related to the length reached by the sprouts or with the growth in diameter of the stems (p>0.005) which may imply a compromise (trade-off) with the growth of the plant, but if it is related to the foliar area and the number of leaves produced.Objetivo: Analizar la capacidad de rebrote, crecimiento y supervivencia después de un evento de remoción de biomasa aérea en Smallanthus pyramidalis (Triana) H. Rob., especie colonizadora, potencial para usar en restauración ecológica y en sistemas silvopastoriles de los Andes Colombianos.
Metodología: se seleccionaron individuos aleatoriamente en una parcela de 120 m2y se realizaron dos tratamientos (T1 y T2) más el testigo (T3). En T1 se realizó corte del tallo a 50 cm del suelo y en T2 a 100 cm del suelo y se evaluó a lo largo de un año la longitud de rebrotes, diámetro y altura del tallo después del corte, número de hojas, área foliar, proporción de hojas depredadas y porcentaje de supervivencia, para comparar la respuesta de estas variables frente a la remoción de biomasa aérea a diferentes alturas de corte.
Resultados: se observó que al año los rebrotes alcanzaron más de 100 cm de longitud, área foliar de 350 cm2y supervivencia de individuos por tratamiento mayor al 75% . La altura del corte no está relacionada con la longitud que alcanzaron los rebrotes ni con el crecimiento en diámetro de los tallos (p>0.005) lo que puede implicar un compromiso (trade-off) con el crecimiento de la planta, pero sí se relaciona con el área foliar y el número de hojas producidas
“Effectiveness” in Adaptive Reuse of Modern Heritage Buildings
No full textAdaptive reuse (AR) of modern buildings, including industrial buildings from the late 19th and 20th centuries, is a complex process as it involves many actions and actors, which influence the result of projects. Effective AR can provide many advantages for societies. This paper aims to provide an overview of the three most highlighted criteria, mentioned by previous researchers, for assessing effectiveness of AR of modern buildings.This research followed seven steps: 1.Reviewing the criteria of “effectiveness” in AR projects in the literature 2.Collecting the data (jury reports of NRP and Europa-Nostra awards) 3.Distilling the reports related to modern heritage buildings 4.Translation of Dutch reports in English 5.Analysing and coding the texts following the criteria mentioned in the literature 6.Analysing the role of effective AR of modern heritage buildings in providing sublimation and social value 7.Formulating some conclusions/recommendations.This review indicates despite the attribution of the effectiveness of AR of non-modern heritage buildings to the attraction of tourists, the effectiveness of AR in modern buildings is often attributed to positive effects on the surroundings and local community. Moreover, in modern buildings, compared to non-modern buildings, qualities provided by new interventions are highlighted more. This can be related to open space plans, stronger materials, wider spans, and spacious urban settings providing a higher tolerance for acceptable change.By revealing the aspects of effectiveness within these two criteria, this study contributes to the broader understanding of the AR potential of modern buildings. Though this review is useful for encouraging the reuse of modern buildings, the methods/tools to be used to achieve effective results need more investigation in future research.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Heritage & TechnologyHeritage & Desig
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