1,904 research outputs found
In vitro cultured fibroblasts irradiated by a IR-laser: effects obtained varying the distance and the length of irradiation
No full textArrhythmogenic cardiomyopathy: electrical instability and intercalated disc abnormalities in transgenic mice
No full textAims: Mutations in genes encoding desmosomal proteins have been implicated in the pathogenesis of arrhythmogenic right ventricular cardiomyopathy (ARVC). However, the consequences of these mutations in early disease stages are unknown. We investigated
whether mutation-induced intercalated disc remodeling impacts on electrophysiological properties before the onset of cell death and replacement fibrosis.
Methods and Results: Transgenic mice with cardiac overexpression of mutant Desmoglein2 (Dsg2) Dsg2-N271S (Tg-NS/L) were studied before and after the onset of cell death and replacement fibrosis. Mice with cardiac overexpression of wild-type Dsg2 and wild-type
mice served as controls. Assessment by electron microscopy established that intercellular space widening at the desmosomes/adherens junctions occurred in Tg-NS/L mice before the onset of necrosis and fibrosis. At this stage, epicardial mapping in Langendorff-perfused
hearts demonstrated prolonged ventricular activation time, reduced longitudinal and transversal conduction velocities, and increased arrhythmia inducibility. A reduced action
potential upstroke velocity due to a lower Na+ current density was also observed at this stage
of the disease. Furthermore, co-immunoprecipitation demonstrated an in vivo interaction
between Dsg2 and the Na+ channel protein NaV1.5.
Conclusion: Intercellular space widening at the level of the intercalated disc (desmosomes/fascia adherens junctions) and a concomitant reduction in action potential upstroke velocity, as a consequence of lower Na+ current density, leads to slowed conduction and increased arrhythmia susceptibility at disease stages preceding the onset of necrosis and replacement
fibrosis. The demonstration of an in vivo interaction between Dsg2 and NaV1.5 provides a
molecular pathway for the observed electrical disturbances during the early ARVC stages
Modificazioni indotte dalla somministrazione simultanea di 17betaestradiolo e progesterone su fibroblasti cutanei di pazienti con Ca mammario
No full textDifferent proliferative capacity of human fibroblasts after 17 beta-estradiol administration
No full text[In vitro growth of skin fibroblasts of patients with atypical ductal hyperplasia of the breast: effects of 17 beta-estradiol]
No full textStudies in vitro about fibroblasts drown from healthy women and patients suffering from breast carcinoma treated with 17beta estradiol, progesterone and cisplatinum
No full textDemand for Cultural Heritage
No full textPrepared for the Handbook of the Economics of Cultural Heritage. Forthcoming in Edgard Elgar Publisher. Anna Mignosa and Ilde Rizzo (editors)cultural economics, demand, cultural heritage, participation in the arts, SPPA2008
Globalization of Distinguished Supercuspidal Representations of GL(n)
No full textAn irreducible supercuspidal representation of = GL(n, ), where is a nonarchimedean local field of characteristic zero, is said to be “distinguished” by a subgroup of and a quasicharacter of if Hom(, ) ≠ 0. There is a suitable global analogue of this notion for an irreducible, automorphic, cuspidal representation associated to GL(n). Under certain general hypotheses, it is shown in this paper that every distinguished, irreducible, supercuspidal representation may be realized as a local component of a distinguished, irreducible automorphic, cuspidal representation. Applications to the theory of distinguished supercuspidal representations are provided
Restriction of Representations of GL (n + 1, ℂ) to GL (n, ℂ) and Action of the Lie Overalgebra
No full textConsider a restriction of an irreducible finite dimensional holomorphic representation of GL(n+1,C) to the subgroup GL(n,C). We write explicitly formulas for generators of the Lie algebra gl(n+1) in the direct sum of representations of GL(n,C). Nontrivial generators act as differential-difference operators, the differential part has order n − 1, the difference part acts on the space of parameters (highest weights) of representations. We also formulate a conjecture about unitary principal series of GL(n,C).© The Author(s) 201
The Balanced Voronoi Formulas for
No full textAbstract
In this article, we show how the Voronoi summation formula of [13] can be rewritten to incorporate hyper-Kloosterman sums of various dimensions on both sides. This generalizes a formula for with ordinary Kloosterman sums on both sides that was used in [1] to prove nonvanishing of GL(4) -functions by GL(2)-twists, and later by the second-named author in [16].</jats:p
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