368 research outputs found
Low plasmatic concentration of intensified antiretroviral therapy in a pregnant woman: a case report
No full textIdentifying the most appropriate antiretroviral regimen for pregnant women with Human Immunodeficiency Virus (HIV-1) infection can be challenging, mainly due to pregnancy-related physiological alterations which can significantly reduce maternal drug plasma concentration. We would like to report our experience as it consists of an unusual case of low plasmatic concentration of antiretroviral drugs despite regimen intensification in a HIV-positive pregnant woman. It also underlines the need for accurate monitoring and treatment adjustment in pregnant women with Human Immunodeficiency Virus (HIV)
Dolutegravir monotherapy and body weight gain in antiretroviral naïve patients
No full textno abstract available; Correspondenc
Efficacy and safety of abacavir/lamivudine with raltegravir in treatment-experienced and treatment-naïve patients with HIV-1 infection: an observational, retrospective, multi-centre study
No full textRaltegravir (RAL) is an HIV-1 integrase strand transfer inhibitor that is well established as a component of highly active antiretroviral therapy regimens for the treatment of adults living with human immunodeficiency virus (HIV), due to its high virological efficacy and good tolerability profile. To date, limited data are available on the use of RAL with abacavir/lamivudine (ABC/3TC). We investigated retrospectively 62 HIV-1 infected patients managed by three Italian Infectious Diseases Outpatient Departments, including 57 treatment-experienced patients and 5 treatment-naïve patients, treated with ABC/3TC plus RAL. In all five naïve patients (100%), virological suppression was achieved and maintained , while 55 experienced patients (96.5%) maintained viral suppression at the most recent review. In the treatment-experienced patients, we observed a significant decrease in triglyceride levels (p < 0.01), while liver transaminases, renal function and cholesterol levels remained substantially stable. In the 34 treatment-experienced patients who switched from a protease inhibitor (PI)-based regimen, we observed a significant improvement of total cholesterol (p=0.03) and triglyceride (p < 0.01) levels. No significant alterations were found on renal and liver function and serum lipid profile of treatment-naïve patients. Despite the small number of participants, results support the efficacy and safety of ABC/3TC plus RAL, either in treatment-naïve or treatment-experienced patients
Increase in visceral adipose tissue in a woman living with HIV after introduction of integrase strand transfer inhibitor
No full textIntegrase strand transfer inhibitors (INSTIs) are a class of antiretroviral drugs with high virologic efficacy and excellent tolerability. Recent evidence showed a possible link of dolutegravir-based regimens with weight gain, and a relationship between raltegravir use and changes in adipose tissue density and metabolic abnormalities, with an increased cardiovascular risk, has been suggested. We describe a case where dolutegravir monotherapy led to a decrease in adipose tissue density
Sebastiano Moruzzi, Vaghezza. Confini, cumuli e paradossi, Laterza, Bari 2012, pp. 196
No full textThe text offers a Critical Review of "Vaghezza. Confini, cumuli e paradossi" by Sebastiano Moruzzi. The author critically reflects on the book by considering its methodologies, its arguments, and its relation with other books of the same type and on the same subject.Il testo propone una Lettura Critica del libro "Vaghezza. Confini, cumuli e paradossi" di Sebastiano Moruzzi. L'autrice riflette criticamente sul libro considerandone le metodologie, gli argomenti e il nesso con altri libri dello stesso tipo e sullo stesso argomento
Client-consultant interaction practices: Sources of ingenuity, value creation and strategizing
No full textService providers increasingly choose to interact with their clients. Previous studies show that client’s resources and activities can influence the service provider’s ability to create value, to be creative, and to develop competitive strategies. Yet several gaps can be identified in the literature regarding how these abilities are impacted by client-consultant interaction (c-c-i) practices. The purpose of this doctoral thesis is to explain the service providers’ varying ability to offer highly valuable solutions to their clients’ problems, in terms of the practices through which consultants interact with their clients. The main research questions are;
How do client-consultant interaction practices influence a firm’s ability to offer unique value propositions and deliver ingenious solutions, and how do these practices influence the formation of the firm’s strategy? These questions are answered through four papers. Each paper answers a sub-question.
Paper 1 focuses on the impact of c-c-i practices on the service providers’ ingenuity capabilities. The paper asks how project teams shatter constraints in ill-structured problem-solving situations, and what implications this finding has for the understanding of creative action in organizations. This paper sheds light on the c-c-i practices through which project teams shatter their constraints and create ingenious solutions.
Paper 2 focuses on the creative aspects of c-c-i practices and presents the experiences of service providers who have been successful in capitalizing on the creative resources provided by their clients.
Paper 3 is an inquiry into the relationship between c-c-i practices and the service providers’ ability to offer unique value propositions. The paper provides a model to define and assess value created through c-c-i practices. The findings of this paper show that value creation is maximized through c-c-i practices that provide access to various forms of capital and practice that enable capital exploitation. Unique value offerings can be developed from knowing what c-c-i practices to enact in different circumstances.
Paper 4 focuses on the implications of c-c-i practices for the emergence of new strategies. The findings show that mundane business operations can be the locus of strategizing, and that clients can play a role in emergent strategy formation. Theoretical resources for this research are drawn from literature on practice theory, strategy, organizational creativity, and value creation. An explorative research design is used and qualitative data are gathered from 30 cases through extensive field work. Both in-depth and comparative case analyses are performed
Client-consultant interaction practices: Sources of ingenuity, value creation and strategizing
No full textService providers increasingly choose to interact with their clients. Previous studies show that client’s resources and activities can influence the service provider’s ability to create value, to be creative, and to develop competitive strategies. Yet several gaps can be identified in the literature regarding how these abilities are impacted by client-consultant interaction (c-c-i) practices. The purpose of this doctoral thesis is to explain the service providers’ varying ability to offer highly valuable solutions to their clients’ problems, in terms of the practices through which consultants interact with their clients. The main research questions are;
How do client-consultant interaction practices influence a firm’s ability to offer unique value propositions and deliver ingenious solutions, and how do these practices influence the formation of the firm’s strategy? These questions are answered through four papers. Each paper answers a sub-question.
Paper 1 focuses on the impact of c-c-i practices on the service providers’ ingenuity capabilities. The paper asks how project teams shatter constraints in ill-structured problem-solving situations, and what implications this finding has for the understanding of creative action in organizations. This paper sheds light on the c-c-i practices through which project teams shatter their constraints and create ingenious solutions.
Paper 2 focuses on the creative aspects of c-c-i practices and presents the experiences of service providers who have been successful in capitalizing on the creative resources provided by their clients.
Paper 3 is an inquiry into the relationship between c-c-i practices and the service providers’ ability to offer unique value propositions. The paper provides a model to define and assess value created through c-c-i practices. The findings of this paper show that value creation is maximized through c-c-i practices that provide access to various forms of capital and practice that enable capital exploitation. Unique value offerings can be developed from knowing what c-c-i practices to enact in different circumstances.
Paper 4 focuses on the implications of c-c-i practices for the emergence of new strategies. The findings show that mundane business operations can be the locus of strategizing, and that clients can play a role in emergent strategy formation. Theoretical resources for this research are drawn from literature on practice theory, strategy, organizational creativity, and value creation. An explorative research design is used and qualitative data are gathered from 30 cases through extensive field work. Both in-depth and comparative case analyses are performed
A 3V 15b 157W Cryo-CMOS DAC for Multiplexed Spin-Qubit Biasing
No full textThis paper presents a 15b cryo-CMOS DAC for multiplexed spin-qubit biasing implemented in a 22-nm FinFET process. The integrating-DAC architecture and the robust digitally-assisted high-voltage output stage enable a low power dissipation (157W) and small area (0.08mm2) independent of the number of biased qubits, and a 3V output range well beyond the nominal supply. This represents the first scalable solution for cryo-CMOS qubit biasing, which achieves a 1.8× better voltage resolution with a lower DNL over a 3× larger output range than the current state-of-the-art. Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.QCD/Sebastiano LabElectronicsQuantum Circuit Architectures and Technolog
Methodological quality of studies evaluating the burden of drug-resistant infections in humans due to the WHO Global Antimicrobial Resistance Surveillance system target bacteria
No full textThe health impact of antimicrobial resistance (AMR) has not been included in the Global Burden Disease (GBD) report, as reliable data has been lacking. AMR burden estimates have been derived from models combining incidence and/or prevalence data from national and/or international surveillance systems and mortality estimates from clinical studies. Depending on utilized empirical data, statistical methodology and applied endpoints, the validity and reliability of results can substantially differ
Nano-MOSFET - Foundation of Quantum Computing Part I
No full textAs big strides were being made in many science fields in the 1970s and 80s, faster computation for solving problems in molecular biology, semiconductor technology, aeronautics, particle physics, etc., was at the forefront of research. Parallel and super-computers were introduced, which enabled problems of a higher level of complexity to be solved. At about the same time, Nobel-laureate physicist Richard Feynman launched what seemed at the time a wild idea; to build a computer based on quantum physics concepts such as superposition and entanglement [1]. The outrageousness of his ideas is documented in the book 'Surely, You're Joking, Mr. Feynman' [2].Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.QCD/Vandersypen LabQCD/Sebastiano LabQuantum Circuit Architectures and Technolog
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