255 research outputs found
Chronic Fatiguing Illnesses: Entering the era of new biomarkers and therapies
No full textIllnesses characterized by chronic fatigue are often defined by symptoms and not by objective biomarkers that support both diagnosis and treatment. Without readily obta ined b io marke rs, c linica l ma na ge me nt ca n be compromised by lack of certainty. This uncertainty creates a wide spectrum of possible therapies that in many cases is reduced to trial and error medicine, resulting in patient frustration and resource exhaustion, with little improvement in health status. Modern medicine must leverage modern science to bring common research tools into the clinic for patient diagnostics. Using biomarkers previously confirmed as useful in diagnosis and treatment of chronic inflammatory response syndrome (CIRS), including transcriptomics, the authors present evidence of benefit in assessment of a “symptoms-only illness.” These immune biomarkers, such as transforming growth factor beta (TGFb), vasoactive intestinal peptide (VIP), melanocyte stimulating hormone (MSH), split produc ts o f co mp le me nt act ivat io n, and ma ny ot hers disc ussed he re, are now a va ilab le for use a s c linica l diagnostics, but rarely ordered in cases of chronic illness. In cases of cognitive decline, new technology for brain MRI analysis, NeuroQuant, can pick up small changes in brain structures that are frequently missed by radiologists, but consistently shown in CIRS. By focusing on persistent symptoms seen in antibiotic-treated Lyme disease (Post-Lyme Syndrome, PLS), CIRS-biomarkers have utility to define both an initial infectious process and a subsequent inflammatory illness. Genomic testing can determine predisposition to chronic stages of Lyme after acute illness and use of Next Generation Sequencing now brings transcriptomics to the Lyme community, to assess remaining abnormalities at any given treatment stage of PLS. Application of these new, object ive tes t ing o ffe r ings w ill re vea l t he mo le c ular pathophysiology of illness, avoiding over-reliance on symptoms and antibody testing alone. This will help providers direct highly targeted therapies on an individual basis, in this era of personalized medicine
Prominent features of a northern tour. Written from a brief diary, kept in travelling from Charleston, S. C. to, and through Rhode Island, Massachusetts, New-Hampshire, Vermont, Lower and Upper Canada, New York, Maine, North-Carolina, South Carolina, and back to Charleston again, Commencing on the 12th of June, 1821, and terminating the 12th of November following.
No full textShoemaker 10021Electronic reproduction. Washington, D.C. : Library of Congress, [2002-2003
Inflammatory Responses Acquired Following Environmental Exposures Are Involved in Pathogenesis of Musculoskeletal Pain
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Sick building syndrome (SBS) and exposure to water-damaged buildings: Time series study, clinical trial and mechanisms
No full textReviewing the attributes of quality plants and therapeutic landscapes associated with special populations
No full textHorticulture has long been used as a therapeutic medium that benefits special populations. More recently the connection has been made between using landscape quality as a means of improving the efficiency and effectiveness of horticultural therapy programming. Both plants and landscape quality may be analysed from two different perspectives, objective quality and perceived quality. Objective quality refers to the technical and measurable nature applicable to landscape plants, products, processes and service procedures; and subjective or perceived quality refers to the nominative or psycho-physical value judgement and/or perceptions associated with landscape quality. Both perspectives, when discussed cooperatively with the horticultural therapist and health care professional could lead to a quality horticultural therapy experience. Research shows that an understanding of both the objective and perceived attributes of landscape plants may lead to improved ways of sustaining quality horticultural therapy programming of special populations. The author discusses the dynamic nature of plants and the complexities involved in landscape plant usage when working with people with special needs. Little is known about the linkages between horticultural plants and horticultural activities and quality horticultural therapy benefits
Molecular Quadrupole-Moment and Effective-Quadrupole-Centre of Fluorobenzene
No full textMeasurements of the infinite-dilution molar field-gradient birefringence constant, Kerr constant and Cotton-Mouton constant of fluorobenzene as a solute in carbon tetrachloride at 25°C and at two visible-spectrum wavelengths (441.6 and 632.8 nm) are reported. Analysis of the observations, in conjunction with other known electric and magnetic properties of fluorobenzene, yields the out-of-plane component of the molecular quadrupole moment relative to the effective-quadrupole-centre, establishes that at both wavelengths the effective-quadrupole-centre is close to the centre-of-ring, and permits the evaluation of a combination of elements of the dipole-qudrupole polarizability, A, and the optical-activity tensor, G′. A complete, although approximate, specification of the centre-of-mass quadrupole moment can be obtained by invoking reasoning due to Shoemaker and Flygare; the result (Θ/10 C m, Θ/10 C m, Θ/10 C m) now found (-1.5 ± 2.9, 22.5 ± 2.7, -21.0 ± 1.0) is at variance with that from the microwave Zeeman effect of this molecule (-6.3 ± 2.7, 17.0 ± 5.0, -10.7 ± 5.0)
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