43 research outputs found
Letter from Bishop E. Mulhern to Hagan
No full textHolograph letter from Bishop E. Mulhern, Ardmaine, Newry (County Down), to (Hagan), following up on his telegram, explaining that he could not have done anything in a matter concerning an author of a book [on Ulster]. Recounting the experience of an explosion heard the previous night the cause of which is still unclear. Commenting that 'Raphoe is dragging a "lengthening chain"' after a prolonged investigation; that Dr. O'D[onnell] can now appoint parish priests but might not care to exercise the privilege since the main parishes are endowed
RTIInternational/childcare_lead_BNmodels: Improved Decision Making for Water Lead Testing in U.S. Child Care Facilities Using Machine-Learned Bayesian Networks
No full textThis release provides all the data and code needed to recreate the Bayesian Network (BN) models used to predict building-wide water lead risk in child care facilities in the publication below:
Mulhern, R. E.; Kondash, A.; Norman, E.; Johnson, J.; Levine, K.; McWilliams, A.; Napier, M.; Weber, F.; Stella, L.; Wood, E.; Lee Pow Jackson, C.; Colley, S.; Cajka, J.; MacDonald Gibson, J.; Redmon, J. H. "Improved Decision Making for Water Lead Testing in U.S. Child Care Facilities Using Machine-Learned Bayesian Networks." Environmental Science and Technology. Under review.
Please view the README file for detailed instructions for how to use the data and code
Evaluating the effectiveness of point of use UVC-LED disinfection of activated carbon block filter effluent in private well water in North Carolina
No full textPoint of use (POU) water treatment systems such as activated carbon block (ACB) filtration are efficient and cost-effective for providing safe drinking water to private well users as private wells are not regulated by federal or state authorities. ACB filters effectively remove chemical but not microbial contaminants. This research investigates the effectiveness of Ultraviolet-C (UVC) light disinfection for treating ACB effluent from private well water. An ACB filter followed by a UVC disinfection device were installed in 17 homes relying on private wells in North Carolina. Influent and effluent samples were collected monthly for 5 months. Total coliform, E. coli, heterotrophic plate count (HPC) and male specific coliphages were assayed in all samples. Heterotrophic bacteria, and male specific coliphages did not change significantly, however a marginally significant decrease of total coliform was found in UV effluent samples. The species richness of heterotrophic bacteria decreased from the UV influent to effluent.Master of Scienc
Personal Internalization of a Confederate Monument Removal Event Associated with Increased Depression, Anxiety, and Stress Among University Students
No full textThis study sought to determine the association between racialized events relating to the removal of a Confederate monument and mental health outcomes among students at a Southern state-university in the United States. After the removal of a Confederate monument located on the university’s campus, racialized protests and violent clashes with police forces ensued. To assess the impact of these events on student mental health outcomes, a cross-sectional survey was disseminated to 10,000 current students. Student mental health was measured using the 21-item Depression, Anxiety, and Stress Scale (DASS). The key exposure, personal internalization of the event, was measured using the seven-question Centrality of Event Scale (CES) and was defined as the perceived importance of the racialized event for the students’ identity and life story. Student demographic information including race, ethnicity, gender, age, and minority status was collected anonymously. Logistic regression was used to compare mental health outcomes of students with high versus low personal internalization of the event, with an interaction term included to capture if the relationship was stronger among students who identified as a minority. After adjusting for minority status, higher internalization of the event was associated with adverse mental health outcomes (OR = 1.96 [95%CI, 1.18-3.25]). However, there was insufficient evidence to determine that minority status modified the results, which may be due to limited power. Overall, these findings demonstrate that increased internalization of the removal event was associated with adverse mental health outcomes among students during the first two weeks of the academic semester, underscoring the importance of state and university official’s consideration of the mental health implications of racial tensions arising from Confederate monument removal events for diverse student populations and strategies for mitigating these outcomes
Evaluating and modeling the activated carbon adsorption of wastewater-derived N-nitrosodimethylamine precursors
No full textActivated carbon adsorption of wastewater-derived NDMA precursors indicates distinctive micropollutant characteristics, and can be well-predicted from bench-scale results.</p
results from the ICEBERG study
No full textFunding Information: AJO-M: received grants from Compass Pathways, Ltd., Janssen and Schuhfried GmBH; investigator driven research funded by Funda\u00E7\u00E3o para Ci\u00EAncia e Tecnologia (PTDC/SAU-NUT/3507/2021; PTDC/MED-NEU/1552/2021; PTDC/MED NEU/31331/2017), Funda\u00E7\u00E3o para Ci\u00EAncia e Tecnologia and FEDER (PTDC/MED-NEU/30845/2017_LISBOA-01-0145-FEDER-030845; PTDC/MEC-PSQ/30302/2017_LISBOA-01-0145-FEDER-30302), the European Research Council (ERC-2020-STG-Grant 950357), the European Union Horizon programmes H2020 SC1 2017 CNECT 2 777167 BOUNCE; (H2020 SC1 DTH 2019 875358 FAITH; HORIZON-HLTH-2023-DISEASE-03-101137378-PsyPal) and the European Joint Programme in Rare Diseases (Joint Translational Call 2019) through Funda\u00E7\u00E3o para Ci\u00EAncia e Tecnologia (EJPRD/0001/2020); received payment, honoraria or support for attending meetings from MSD, Neurolite AG Angelini, Janssen and the European Monitoring Centre for Drugs and Drug Addiction; Vice-President of the Portuguese Society for Psychiatry and Mental Health; Head of the Psychiatry Working Group for the National Board of Medical Examination (GPNA) at the Portuguese Medical Association and Portuguese Ministry of Health. BR, YG, and SM-H: Employees of Janssen; hold Johnson & Johnson company stocks/stock options. Funding Information: The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The authors declare that this study received funding from Janssen EMEA. This article was based on the original studies NCT02497287 and 54135419DEP4001, both sponsored by Janssen EMEA. Support for third-party writing assistance for this article, provided by Laura Mawdsley, MSc, Costello Medical, Cambridge, UK, was funded by Janssen EMEA in accordance with Good Publication Practice (GPP 2022) guidelines. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. Funding Information: The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The authors declare that this study received funding from Janssen EMEA. This article was based on the original studies NCT02497287 and 54135419DEP4001, both sponsored by Janssen EMEA. Support for third-party writing assistance for this article, provided by Laura Mawdsley, MSc, Costello Medical, Cambridge, UK, was funded by Janssen EMEA in accordance with Good Publication Practice (GPP 2022) guidelines. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. Acknowledgments Publisher Copyright: Copyright © 2024 Oliveira-Maia, Rive, Godinov and Mulhern-Haughey.Introduction: Treatment resistant depression (TRD) affects approximately 10–30% of patients with major depressive disorder, and most patients with TRD do not respond to real-world treatments (RWT). Treatment with esketamine nasal spray (NS) plus a selective serotonin or serotonin norepinephrine reuptake inhibitor (SSRI/SNRI) has significant long-term clinical benefit over RWT in patients with TRD. However, the impact on patient-reported function remains to be determined. Methods: The ICEBERG analysis was an indirect treatment comparison performed using data from two studies of patients with TRD: SUSTAIN-2 (esketamine NS; NCT02497287) and the European Observational TRD Cohort (EOTC; RWT; NCT03373253; clinicaltrials.gov). Here, patient−reported functional remission, assessed using the Sheehan Disability Scale (SDS), was defined as SDS ≤6 at Month 6. Analyses were conducted using propensity score re−weighting and multivariable models based on 18 covariates. Results: At Month 6, the probability of functional remission in esketamine NS−treated patients from SUSTAIN-2 (n=512) was 25.6% (95% confidence interval [CI] 21.8–29.4), while the adjusted probability for RWT patients from the EOTC (n=184) was 11.5% (95% CI 6.9–16.1; relative risk: 2.226 [95% CI 1.451–3.416]; p=0.0003). In the total combined population (N=696), patients who did not achieve clinical response or remission had a low probability of achieving functional remission (5.84% and 8.76%, respectively). However, for patients who did achieve clinical response or remission, the probability of achieving functional remission was greater (43.38% and 54.15%, respectively), although many still did not achieve this status. Conclusions: For patients with TRD, esketamine NS had a significant functional benefit versus RWT after 6 months of treatment. Irrespective of treatment, achievement of clinical response or remission was insufficient to attain functional remission. Nevertheless, clinical remission increased the likelihood of achieving functional remission, further supporting an important role for clinical remission in for the path towards functional recovery.publishersversionpublishe
Evaluating Activated Carbon Adsorption of Dissolved Organic Matter and Micropollutants Using Fluorescence Spectroscopy
No full textDissolved
organic matter (DOM) negatively impacts granular activated
carbon (GAC) adsorption of micropollutants and is a disinfection byproduct
precursor. DOM from surface waters, wastewater effluent, and 1 kDa
size fractions were adsorbed by GAC and characterized using fluorescence
spectroscopy, UV-absorption, and size exclusion chromatography (SEC).
Fluorescing DOM was preferentially adsorbed relative to UV-absorbing
DOM. Humic-like fluorescence (peaks A and C) was selectively adsorbed
relative to polyphenol-like fluorescence (peaks T and B) potentially
due to size exclusion effects. In the surface waters and size fractions,
peak C was preferentially removed relative to peak A, whereas the
reverse was found in wastewater effluent, indicating that humic-like
fluorescence is associated with different compounds depending on DOM
source. Based on specific UV-absorption (SUVA), aromatic DOM was preferentially
adsorbed. The fluorescence index (FI), if interpreted as an indicator
of aromaticity, indicated the opposite but exhibited a strong relationship
with average molecular weight, suggesting that FI might be a better
indicator of DOM size than aromaticity. The influence of DOM intermolecular
interactions on adsorption were minimal based on SEC analysis. Fluorescence
parameters captured the impact of DOM size on the fouling of 2-methylisoborneol
and warfarin adsorption and correlated with direct competition and
pore blockage indicators
Evaluating Activated Carbon Adsorption of Dissolved Organic Matter and Micropollutants Using Fluorescence Spectroscopy
No full textTHE PRAIRIE NATURALIST Volume 29, No.4. December 1997
No full textBUTTERFLY SPECIES IN NATIVE PRAIRIE AND RESTORED PRAIRIE ▪ D. M. Debinski and A. M. Babbit
BACK-CALCULATED LENGTH-AT-AGE ESTIMATES FROM TWO SCALE RADII ▪ K. L. Hurley, K. L. Pope, and D. W. Willis
DIET OF NORTH DAKOTA ELK DETERMINED FROM RUMEN AND FECAL ANALYSES ▪ R. G. Osborn, J. A. Jenks, and W. F. Jensen
INTERSPECIFIC COMPETITION FOR FOOD BETWEEN WHITE-FOOTED MICE AND EASTERN WOODRATS ▪ B. G. Aloiau, D. M. Post, and E. A. Home
NESTING PIPING PLOVER AND LEAST TERN ON THE KANSAS RIVER ▪ W. H. Busby, D. W. Mulhern, P. G. Kramos, and D. A. Rintoul
MAMMALS OF KONZA PRAIRIE: NEW OBSERVATIONS AND AN UPDATED SPECIES LIST ▪ B. R. McMillan, D. W. Kaufman, G. A. Kaufman, and R. S. Matlack
NOTES
Micropeplus cribatus in South Dakota (Coleoptera: Staphyllnldae) ▪ P. J. Johnson
First European Starling In North Dakota ▪ C. S. Houston
Recent Bald Eagle Nesting Acttvlty In Nebraska ▪ J. Lackey
Range Extension of the Grass Pickerel Into South Dakota ▪ B. E. Van Zee and C. G. Scalet
Reviewers for Volume 29
Author Index· Volume 29
Subject Index· Volume 29
Erratum
Announcement
Measuring the Burden of Schizophrenia Using Clinician and Patient-Reported Measures: An Exploratory Analysis of Construct Validity
No full text\ua9 2019, The Author(s). Background: Various self-reported or clinician-reported (as a proxy) measures exist to quantify the burden of schizophrenia on patients. Evidence of the psychometric relationship between these measures to inform their practical use is limited. Objectives: Our objective was to conduct an exploratory analysis of the construct validity of patient-reported (EQ-5D, SF-6D, WEMWBS, SQLS subscales of Psychosocial, Motivation, Symptoms) versus clinician-reported measures (PANSS, CGI-SCH, NSA-4, HoNOS-PbR) to inform future use of patient-reported measures for burden-of-illness assessment and/or economic evaluation. Methods: In an adult patient population with schizophrenia, construct validity was assessed in relation to convergent and known-group validity. Convergent validity was assessed using Spearman’s rank absolute correlation strength (ACS: weak ≤ 0.3, moderate = 0.3 < 0.5, strong ≥ 0.5) and graphically using locally weighted scatterplot smoothing (LOWESS) techniques. Known-group validity was assessed using Cohen’s d absolute effect size (AES: small ≤ 0.5, moderate = 0.5 < 0.8, large ≥ 0.8). Floor and ceiling effects were assessed as a proxy of sensitivity in this cross-sectional study. Statistical significance was assessed at the 5% threshold level (p < 0.05). Across head-to-head assessments, the frequency of producing the strongest ACS, largest AES, and statistically significant results determined the best overall construct validity. Results: Overall, 304 patients consented to the study. In relation to statistically significant results, the SF-6D most frequently exhibited the strongest ACS and largest AES against the clinician-reported measure scores (ACS range 0.084–0.436; AES range 0.043–0.746), and the SQLS Motivation subscale most frequently exhibited the weakest/smallest values (ACS range 0.009–0.157; AES range 0.002–0.397), although these results were mixed according to the clinician-reported measure used for comparative analysis (ACS range 0.009–0.529; AES range 0.002–0.934). Conclusion: The SF-6D indicated the best (mostly moderate) construct validity but still missed the negative symptoms of the condition. Although further evidence is required to confirm or refute these exploratory results, compared with the EQ-5D, the SF-6D can be self-reported to better capture generic health-related quality-of-life aspects of schizophrenia for the purpose of economic evaluation. The lack of construct validity for SQLS Motivation and Symptoms subscales were hypothesized post-hoc to be representative of the complementary information elicited by the subscales not captured by the clinician-reported measures. Therefore, the SQLS can be self-reported to capture complementary (i.e., additional) information relative to clinician-reported measures
