9,302 research outputs found
Letter from K.W. Lee to Friends of Michi Weglyn, November 1, 1997
No full textA letter from K. W. (Kyung Won) Lee, an investigative journalist who wrote for the Sacramento Union, to the Friends of Michi Weglyn. Lee wrote that Weglyn was instrumental in the campaign to free Chol Soo Lee, a Korean American man was on death row, but later had his convictions overturned. Lee also wrote that other Japanese American activists were instrumental to the success of this campaign.These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn
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Host-Factor Enhancement of Therapy for Tuberculosis
No full textHost-Factor Enhancement of Therapy for TuberculosisbyMichael David SchumpDoctor of Philosophy in Infectious Diseases and ImmunityUniversity of California, BerkeleyProfessor Lee W. Riley, ChairTuberculosis (TB) is a disease of major public health importance and improvements to its treatment could greatly benefit efforts aimed at eliminating the disease. Current treatment options for TB are limited in effectiveness and have numerous fundamental failings due to the necessarily lengthy duration of therapy and toxicity of the antimicrobial drugs deployed, among other issues. The studies described herein where undertaken with the goal of developing adjunctive treatments or modifications of existing treatments which could improve the treatment course, outcome, or both for standard TB antimicrobial chemotherapy.Three areas of research are discussed beginning with adaptive immune augmentation through therapeutic vaccination, proceeding to investigations of innate immune adjuvant therapy and concluding with host environment mediated improvement of selectivity index of TB antimicrobial compounds.A post-treatment, therapeutic vaccine was studied with the goal of developing a tool which could prevent relapse or reactivation disease. Though the project was a follow up to a study which demonstrated exceptional protection, the vaccine candidate did not demonstrate any detectable efficacy in three parallel murine infection experiments. Possible reasons and implications of this failure are discussed.Because correlates of protection for adaptive immunity to TB are poorly understood and have not proven to be tractable for intervention, innate immune enhancement was investigated. Autophagy, a cell-intrinsic process with antimicrobial capabilities, was selected due to its well described tuberculocidal activity and pharmacologic manipulability. However, despite the apparent capacity of some test compounds to increase autophagic flux, none demonstrated robust restriction of mycobacterial growth in murine or human macrophages. That study did, however, lead to the serendipitous discovery that pH based drug partitioning can increase the selectivity index of antimicrobial drugs against M. tuberculosis inside cultured macrophages
Dear SIS Seminar, Nina June Lee, Young Scholar, Fall 2020
No full textNina J. Lee is a graduating senior Comparative Women�s Studies Major from Everett, Massachusetts. After Spelman, she will pursue a Masters of Education in Community Engagement with a concentration in Community Organizations and Nonprofit Management
Figs. 1-8. Capnia shasta male genitalia. Figs. 1-4 in New Morphological Observations And Phylogenetic Placement Of Capnia Shasta (Plecoptera: Capniidae)
No full textFigs. 1-8. Capnia shasta male genitalia. Figs. 1-4. California, Shasta County, creek near Castle Crags State Park. 1. Terminalia, dorsal. 2. Epiproct, dorsal. 3. Epiproct, dorsolateral. 4. Epiproct, lateral. Figs. 5 -8. California, Siskiyou County, tributary, Salmon River, Salmon River Road. 5. Terminalia, dorsal. 6. Epiproct, dorsal. 7. Epiproct, dorsolateral. 8. Epiproct, dorsolateral, anterior.Published as part of Nelson, C. Riley, Baumann, Richard W. & Lee, Jonathan J., 2013, New Morphological Observations And Phylogenetic Placement Of Capnia Shasta (Plecoptera: Capniidae), pp. 122-125 in Illiesia 9 (12) on page 123, DOI: 10.5281/zenodo.475331
Islet Cell and Other Organ-Specific Autoantibodies in Chinese Children with Insulin-Dependent Diabetes Mellitus
No full textCorrespondence from C. Lenwood Lee to W.C. Patton, February 14, 1968
No full textCorrespondence from C. Lenwood Lee to W. C. Patton about starting a voter registration education program. Enclosed is a grant proposal from the Jacksonville, Florida NAACP
A <i>Jhopadpatti</i> in Mumbai, India
No full text<p>There are 6.7 million slum dwellers among Mumbai's 12 million residents. In the Ganesh Murthy Nagar slum in the Colaba district, one resident noted, “We had one small, smelly toilet for a population of 10 000. Women suffered the most because they had to relieve themselves in the open, and could do so only in the early mornings or after dark” [<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0040295#pmed-0040295-b043" target="_blank">43</a>]. There are regular outbreaks of diarrheal diseases, leptospirosis, malaria, and dengue in Mumbai's slums [<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0040295#pmed-0040295-b004" target="_blank">4</a>]. Photo by Lee Riley.</p
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Spectrum of Disease Burden in Urban Informal Settlements of Brazil
No full textAbstractSpectrum of Disease Burden in Urban Informal Settlements of BrazilbyRobert Eugene SnyderDoctor of Philosophy in EpidemiologyUniversity of California, BerkeleyProfessor Lee W. Riley, ChairThere are more than one billion urban informal slum residents worldwide, comprising almost one-third of the global urban population. Slums are characterized by their abundance of risk factors for communicable and non-communicable diseases. Some of these include poor water and sanitation infrastructure, in addition to poor structural housing quality, overcrowding and insecure residential status (i.e. lack of land tenure). Residents of these communities shoulder a greater burden of biologic, spatial and social health determinants of disease and their corresponding disease outcomes than residents of the same city who do not live in slums. Due to systematic disenfranchisement and the complicated logistics involved in studying these populations, our knowledge about their health conditions and determinants of disease occurrence is sparse. This dissertation describes three approaches to begin to address this gap in knowledge.Chapter 1 sets the tone for this dissertation by describing the concept of slums and lays out the evidence for the disproportionate burden of disease borne by slum residents. While not being representative of all slums worldwide - Brazil is now considered an upper-middle-income country by the World Bank– the country’s slums serve as an important case study. Brazil has a relatively robust healthcare system, a functional democracy, and an active research sector, all of which facilitate the collection and comparison of data inside and outside of the country’s slums. Estimates of Brazil’s slum population range from 11,425,644 (6% of the total population) in the 2010 Brazilian Census (the official government estimate) to 45.7 million (28%) estimated by the United Nations Human Settlements Program. In 2010, the Brazilian government carried out a census with the goal of systematically enumerating and describing the physical and demographic characteristics of the country’s slums, coining the technical term aglomerados subnormais (AGSN) to describe slums.Perhaps the most recognizable of all slums in Brazil are the favelas of Rio de Janeiro; these architecturally colorful and culturally vibrant communities accentuate the city’s magnificent physical geography and beauty. Unfortunately, due to their precarious physical location, the quasi-legal land tenure of slum residents, the blatant political corruption, and the persistently poor implementation of the national healthcare system (in 2010 approximately 50% of Rio de Janeiro’s population had access to the Sistema Único de Saúde – SUS), these communities’ residents suffer from stark health inequalities. Chapter 2 uses the 2010 Census to describe the spatial distribution of social determinants of health in Rio de Janeiro. The findings from this analysis highlight differences in age, income, and access to electricity, sanitation, water, and solid waste disposal throughout the city, and point to the possibility that differences in these characteristics contribute to an inequitable distribution of disease between the city’s slum and non-slum areas.Chapter 3 delves more deeply into these inequalities. Given our group’s previously published evidence suggesting that the burden of tuberculosis is greater among residents of Rio de Janeiro’s slums than among residents of non-slum areas, we seek to fulfill a principle public health axiom: that we must seek and apply solutions to improve the health of populations. Chapter 3 evaluates the effectiveness of the directly observed treatment (DOT) program for tuberculosis treatment outcomes among TB cases inside and outside of Rio de Janeiro’s slums. Using the Brazilian Notifiable Disease System, Sistema de Informação de Agravos de Notificação (SINAN), we compare treatment outcomes between TB cases on DOT in AGSN and non-AGSN census tracts. While we found that DOT coverage was low inside and outside of AGSNs, we report that DOT had a greater impact on the cure rate for TB cases in AGSN areas compared to TB cases in non-AGSN areas.Chapter 4 shifts the lens to non-communicable diseases (NCD) and to a different city, Salvador, where thirty-three percent of the population lives in slums. We compare the burden of several NCD (i.e. diabetes mellitus, hypertension, dyslipidemia) and the prevalence of risk factors (i.e. overweight, obesity and smoking) in a convenience sample of residents of Pau da Lima, an urban slum, with residents of the entire city as captured in a telephone survey. This telephone survey is an annual landline-based survey undertaken by the Brazilian Ministry of Health with the express purpose of monitoring the prevalences of NCD and NCD risk factors in Brazil’s capital cities. We age- and sex- standardized the prevalences of these conditions and risk factors and compared them between these two populations. We found that the age- and sex-adjusted prevalences of diabetes mellitus, smoking, being overweight/obese, and being obese, were higher among residents of Pau da Lima than in residents of the entire city of Salvador. A striking finding was that women living in slums suffered a disproportionate burden of being overweight or obese, and men in slums smoked at almost twice the frequency as men in the city as a whole.While these observational studies and analyses do not provide causal evidence for a link between slum residence and adverse health outcomes, they provide preliminary data in support of the hypothesis that residents of slums in several major Brazilian cities have unique social and spatial determinants of health, and subsequently distinct disease profiles, compared to residents of non-slum neighborhoods in the same city.Because of poor access to healthcare and a host of other slum-specific obstacles, slum residents rarely appear in official disease or mortality estimates. Consequently, slum-specific analyses such as those presented in this dissertation that describe the burden of disease among slum residents can be used to design policies aimed at mitigating the inequitable distribution of disease in these communities, also serving as a baseline to evaluate the impact of these policies on the health of this population. The findings from this dissertation should be used to encourage further epidemiologic analyses of slum populations, not only in Brazil, but also among slum populations of megacities elsewhere in the world
Lee Heights School District No. 3821
No full textPhotograph - A view of the Lee Heights School building near Perryvale, Alberta. ATS 11-64-23-W
The Making of a Man
No full textIn The Making of a Man (1892) , James W. Lee argues that the ultimate purpose of creation is the realization of man. The book refutes materialist philosophies by asserting that Mind is "fundamental and prior" to Matter. If matter were primary, man would be meaningless ; instead, the universe is a provision for man's complete nature, structured in chapters. Lee begins with Bread (Physical). The need for food creates commerce , which establishes the social relations essential for human development. Unlike animals, who gain nothing from companionship , men "find themselves by coming together". The ultimate end of all commerce and social relations is "the making of a man".
The Making of a Man (1892) (Bir İnsanın Yaratılışı) kitabında James W. Lee, yaratılışın nihai amacının insanın gerçekleştirilmesi olduğunu savunur. Kitap, Zihnin Maddeden "temel ve öncelikli" olduğunu belirterek materyalist felsefeleri çürütür. Eğer madde birincil olsaydı, insan anlamsız olurdu ; bunun yerine, evren, bölümler halinde yapılandırılmış olan, insanın bütün doğası için bir karşılıktır. Lee, Ekmek (Fiziksel) ile başlar. Yiyecek ihtiyacı ticareti yaratır , bu da insanın gelişimi için gerekli olan sosyal ilişkileri kurar. Arkadaşlıktan hiçbir şey kazanmayan hayvanların aksine, insanlar "bir araya gelerek kendilerini bulurlar". Tüm ticaretin ve sosyal ilişkilerin nihai amacı "bir insanın yapılmasıdır"
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