234 research outputs found
Richard Hodes Oral History Interview
No full textRichard Hodes, a Hillsborough County legislator, physician, and anesthesiologist discusses his career in this oral history. Dr. Hodes began his political career as a Florida legislator and chair of the House Committee on Health and Welfare in 1967. He discusses the changes in the political and administrative landscape of Florida public health, including the funding of the USF College of Medicine and the 1969 revision of the Florida Constitution under Governor Claude Kirk. This revision lead to the extensive reorganization and centralization of public health agencies in Florida under HRS (Health and Rehabilitative Services) and later, the concomitant redistribution of HRS due to its enormous size, variety in agencies, and challenging state level management. Dr. Hodes further discusses the ramifications of the second phase of administrative restructuring leading to the 1976 reorganization of HRS from 25 bureaus, sections and units into 11 districts. Dr. Hodes ends with a discussion of the 1996 Act establishing the Florida Department of Health, an effort to bring Florida’s 67 county health departments more directly under state government control
Hodes, Jane Ellen (Sachs), 1918-2009 (SC 1633)
No full textFinding aid only for Manuscripts Small Collection 1633. Correspondence between Jane Ellen (Sachs) Hodes, Oakland, California and librarians at the Kentucky Library & Museum related to photos and papers in the manuscript collection of Hodes\u27s mother and author, Emanie (Nahm) Sachs Arling Philips. Includes a 1940s letter from Philips to Hodes
The role of drawing in the work of Charlotte Hodes
No full textThis article is based on material from Hodes' Inaugural Professorial Address at London College of Fashion (11 March 2014), which was conducted as a conversation with the author. The article considers the role of drawing within Hodes' overall fine art practice, particularly in relationship to her large-scale papercuts and ceramics. It addresses the manner in which drawing is used by Hodes as a primary research tool, to gather information and assimilate influences, and how digital technology works in conjunction with traditional means of drawing. The article focuses on particular projects to examine how Hodes engages with collections and archives as starting points for a more personal investigation, which invariably involves the female figure as a central motif. In this respect, how Hodes uses herself as the model offers insights into an embodied approach to creativity
Miller, Richard W.
No full textMemorial Statement for Richard W. Miller who died in 2023. The memorial statements contained herein were prepared by the Office of the Dean of the University Faculty of Cornell University to honor its faculty for their service to the university
Toxicological profile for 2,4,6-trinitrotoluene
No full textChemical manager(s)/author(s): Patricia Richter-Torres, Alfred Dorsey, ATSDR, Division of Toxicology, Atlanta, GA; Colette S. Hodes, Sciences International, Inc., Alesandria, VA.Prepared for the U. S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry prepared by Sciences International, Inc. under subcontract to Research Triangle Institute under contract no. 205-93-0606.Bibliographical references: p. 139-171.1995205-93-06061105
Prozac and puberty: the effects of fluoxetine treatment on neurogenesis in the pubescent hippocampus
No full textChronic treatment with fluoxetine (Prozac) increases cell proliferation and neurogenesis in the dentate gyrus of the adult male rat (Encinas et al., 2006; Malberg et al., 2000). Therefore neurogenesis was proposed to be a mechanism through which antidepressants alleviate some symptoms of depression (Jacobs et al., 2000; Duman, 2004a; Sapolsky, 2004). Here we tested whether chronic fluoxetine treatment increases cell proliferation and neurogenesis in pubescent and adult female rats. Rats were injected with fluoxetine (5mg/kg) or saline for 14 days. One day later subjects were injected with 5-bromo-2’- deoxyuridine (BrdU; 200mg/ kg), a marker of dividing cells. Rats in experiment 1 were sacrificed 2hrs after BrdU injection to measure cell proliferation. Subjects in experiment 2 were sacrificed at 24 hrs to measure cell proliferation after a full cell cycle. In experiment 3 subjects were sacrificed 28 days after BrdU injection to measure neurogenesis. At all time points fluoxetine increased proliferation and neurogenesis in adult male rats. However, the drug did not alter proliferation or neurogenesis in pubescent males. Proliferation and neurogenesis were elevated during puberty for both sexes, irrespective of treatment. There were no effects of fluoxetine treatment on proliferation or neurogenesis in females at either age, or across the estrous cycle. Immunofluorescent labeling with BrdU and NeuN a marker of mature neurons verified an effect of fluoxetine treatment only in adult male subjects. Double labeling also indicated that cell fate was not altered at any age by treatment. Blood samples were taken to determine whether fluoxetine altered circulating levels of sex and stress hormones 24 hrs or 29 days after treatment. Treatment decreased corticosterone concentrations in pubescent female rats sacrificed at the later time. There were no other hormonal effects of fluoxetine treatment. These data indicate that pubescent rats respond differently to antidepressants than adults. Hormonal changes in the pubescent female seem especially susceptible to the effects of fluoxetine. In addition, fluoxetine may operate differently in adult females than in adult males. Together, these results indicate that antidepressants probably operate via different neuronal mechanisms in adult males than in other age groups or even the other sex.Ph.D.Includes abstractVitaIncludes bibliographical referencesby Georgia E. Hode
3D 2D: object and illusion in print
No full textThis exhibition consisted of prints from The Centre for Fine Print Research, University of West of England, Bristol
This exhibition featured the new work of a range of artists who have worked at the Centre for Fine Print Research, UWE in Bristol. Each of the works were realised through the use of cutting edge digital print technologies and explore new relationships between the notion of object and illusion made possible by such means.
Such works include Katie Davies and Peter Walters collaborative piece that translates audio data from outerspace to create three dimensional shapes and two dimensional images. Jeremy Gardiner and Anthony Head's piece however, is based around satellite images looking down to earth to map through virtual environments and 2D and 3D renderings an exploration of a section of the Dorset coast. The exhibition also features a work by Richard Hamilton printed at the CFPR in 2003 - The Typo Topography of Marcel Duchamp's Large Glass - which maps and annotates Duchamp's work in the form of a large inkjet print as well as an illuminated print by US artist Lesley Dill and large scale but intricate lasercuts by Charlotte Hodes.
The exhibition was curated by Dr. Paul Thirkell, Senior Research Fellow, Centre for Fine Print Research. Research undertaken at the Centre in relation to cutting edge print techniques includes 3D rapid prototype printing, laser cutting and artist quality wide format inkjet printing
Boyd, Richard Newell
No full textAlso available as a printed booklet and from the Dean of Faculty website https://theuniversityfaculty.cornell.edu/Memorial Statement for Richard Newell Boyd, who died in 2021. The memorial statements contained herein were prepared by the Office of the Dean of the University Faculty of Cornell University to honor its faculty for their service to the university
LOOK AT LINCOLN: Lincoln\u27s Long Funeral Procession Through History
No full textLincoln’s Body by Richard Wightman Fox Publisher: W.W. Norton and Company, Inc. Retail Price: 30.00 ISBN: 97803001...
Hydroxyoctadecadienoic acids regulate apoptosis in human THP-1 cells in a PPARγ-dependent manner
No full textMacrophage apoptosis, a key process in atherogenesis, is regulated by oxidation products, including hydroxyoctadecadienoic acids (HODEs). These stable oxidation products of linoleic acid (LA) are abundant in atherosclerotic plaque and activate PPARγ and GPR132. We investigated the mechanisms through which HODEs regulate apoptosis. The effect of HODEs on THP-1 monocytes and adherent THP-1 cells were compared with other C18 fatty acids, LA and α-linolenic acid (ALA). The number of cells was reduced within 24 hours following treatment with 9-HODE (p < 0.01, 30 μM) and 13 HODE (p < 0.01, 30 μM), and the equivalent cell viability was also decreased (p < 0.001). Both 9-HODE and 13-HODE (but not LA or ALA) markedly increased caspase-3/7 activity (p < 0.001) in both monocytes and adherent THP-1 cells, with 9-HODE the more potent. In addition, 9-HODE and 13-HODE both increased Annexin-V labelling of cells (p < 0.001). There was no effect of LA, ALA, or the PPARγ agonist rosiglitazone (1μM), but the effect of HODEs was replicated with apoptosis-inducer camptothecin (10μM). Only 9-HODE increased DNA fragmentation. The pro-apoptotic effect of HODEs was blocked by the caspase inhibitor DEVD-CHO. The PPARγ antagonist T0070907 further increased apoptosis, suggestive of the PPARγ-regulated apoptotic effects induced by 9-HODE. The use of siRNA for GPR132 showed no evidence that the effect of HODEs was mediated through this receptor. 9-HODE and 13-HODE are potent—and specific—regulators of apoptosis in THP-1 cells. Their action is PPARγ-dependent and independent of GPR132. Further studies to identify the signalling pathways through which HODEs increase apoptosis in macrophages may reveal novel therapeutic targets for atherosclerosis
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