4,839 research outputs found
Structural studies on high oxidation state nickel complexes and their nickel (II) precursors using EXAFS spectroscopy
No full textOctahedral nickel(III) complexes [Ni(L-L)3]X3 (L-L = diamine; X = Cl, Br) have been prepared by oxidation of the corresponding nickel(II) species with halogen in carbon tetrachloride under anhydrous conditions. The structures of the more stable products and all the precursors where investigated using nickel K-edge EXAFS spectroscopy and their Ni-N and Ni..Cbackbone interatomic distances were determined. The ability of this technique to detect substituents beyond the second coordination sphere was also investigated. Tetragonal nickel(III) complexes (Ni(L-L)2X20D (L-L = diamine, N-methyl substituted diamine; X = Cl, Br) have also been synthesised by halogen oxidation of the appropriate nickel(II) precursors. The structures of the starting materials were probed using nickel and bromine K-edge EXAFS data, and these were shown to have either a trans or a cis geometry, depending upon the degree of N-methyl substitution and the presence of aquo ligands. The more stable oxidation products have also been structurally characterized. Octahedral nickel(II), F4-diars and diphos have been prepared and their structures elucidated using a combination of nickel, bromine and arsenic K-edge EXAFS data. The interatomic distances obtained for [Ni(F4-diars)2Br2]BF4 have been compared with those determined by X-ray crystallography and were found to be in excellent agreement. Some Class II mixed-valence nickel(II)/(IV) linear chain complexes have been prepared and a structure re-investigated using XAS. The preliminary findings of a model study for these systems using some platinum and mixed-metal analogues are reported.</p
Lend me your watch and I’ll tell you the time: the thorny issue of leadership in training healthcare professionals in counselling and communication skills
No full textIt would clearly be risible if someone were to ask you for the time, and you in turn asked them to lend you their watch so you could tell them. Much criticism has been levelled at counsellors who will not give a direct answer but rather turn questions back on their clients. Many teachers, subscribing to the Socratic imperative, may do likewise and assume the role of a conduit rather than a leader. Whether they do so through a belief in the process, or a lack of belief in their own leadership skills, they risk evoking frustration or even resentment.We the authors make the following contentions: if the leadership of the teacher or therapist (as director or wise one) is reneged on in place of a laissez-faire client-centeredness, then are we willing to work without goals or outcomes, to set off on a journey without maps, and indulge in a relationship of pure process? Perhaps for the client or student who has made little contribution or sacrifice to be there, this may be acceptable. But in a time when students pay high fees, and clients of all services are increasingly charged, don’t these groups have a right to receive a degree of direction from the professionals they encounter?One assumes that even before Freud’s day, people were helped by being listened to. But today, talking therapies have been subsumed into the ‘toolkits’ of many professionals and, as a consequence, have been substantially demystified. Clients may not know ‘the answer’ but tend to be more able to formulate their questions. And they deserve the respect implicit in the professional’s honouring of their leadership commitment. Both teachers and clinicians therefore need to be able to address their own issues of power and influence, perceived expertise and validation of feelings and expectations. Professionals need to be accountable not only for what they can do, but also for what they cannot do. An honest understanding and acceptance of this does not preclude honouring a leadership role.<br/
Microglial physiology: unique stimuli, specialized responses
No full textMicroglia, the macrophages of the central nervous system parenchyma, have in the normal healthy brain a distinct phenotype induced by molecules expressed on or secreted by adjacent neurons and astrocytes, and this phenotype is maintained in part by virtue of the blood-brain barrier's exclusion of serum components. Microglia are continually active, their processes palpating and surveying their local microenvironment. The microglia rapidly change their phenotype in response to any disturbance of nervous system homeostasis and are commonly referred to as activated on the basis of the changes in their morphology or expression of cell surface antigens. A wealth of data now demonstrate that the microglia have very diverse effector functions, in line with macrophage populations in other organs. The term activated microglia needs to be qualified to reflect the distinct and very different states of activation-associated effector functions in different disease states. Manipulating the effector functions of microglia has the potential to modify the outcome of diverse neurological diseases
Marriage record of Norman, Richard E. and Brown, Aurora
No full textMarriage license for Richard E. Norman and Aurora Brown. Perry Mayland Suites was the officiant
Royce and Perry on Idealism and Realism
No full textThis thesis is primarily an attempt to reconstruct the debate between Josiah Royce and Ralph Barton Perry concerning the viability of both the realist and idealist positions. Secondarily, I will show that this debate is a crucial part of an adequate understanding of the changes that took place in American philosophy in the early part of twentieth century. Royce's arguments against the neorealist position of Perry (and others) centered on both the nature of error, and the nature of independence. Perry' response to these arguments was an elaborate effort to demonstrate a coherent and consistent neorealist system which avoided the problems that Royce claimed must beset any such system. I will not attempt to assign the label of "winner" to either participant, however, I will show that the degree of incommensurability involved in the debate played an important role in the shift in American philosophy at the time.Master of Art
Staging imagination: transformations of Shakespeare in Wordsworth and Coleridge
No full textThis thesis examines the ways that Wordsworth and Coleridge transform the works of Shakespeare, in order to stage the imagination as it functions in the lives of the characters in their poetry. I look especially at the importance of the play A Midsummer Night 's Dream to their poetic project, and show how elements of the play resurface in various poems, prefaces and prose writings of the two poets over a span of nearly twenty years. I argue that Wordsworth's transformations of Shakespeare contribute to a democratising of poetry, and a valorising of 'our common human heart'. Chapter one discusses Lyrical Ballads as a series of poems, which have Theseus' speech on Imagination as their unifying theme, emulating Shakespeare’s staging of passion. Chapters two and three examine Alexander Tytler's Essay on Translation as a 'negative' stimulus for Wordsworth's challenging poetic theories, and a source for some of his earliest 'transformations' of Shakespeare. Chapter four is a detailed survey of the critical background, and the Romantic reception of A Midsummer Night's Dream, and examines key themes in the play to elucidate the poets' poetry and prose. Chapter five is a comparison between 'The Last of The Flock' and The Merchant of Venice, showing how Wordsworth 'imitates' the tale, and transposes the 'tone' of the comic play into a quieter and sadder 'music'. Chapter six analyses 'Michael', as a transformation of Gaunt in Richard into the 'history homely and rude' of Michael the shepherd. Chapter seven is on Coleridge's Biographia Literaria, which re-tells the tale of the genesis of Lyrical Ballads, and Wordsworth's transformative poetics, as a 'translation' of A Midsummer Night’s Dream. Chapter eight returns to Alfoxden, and Hazlitt's 'First Acquaintance with Poets', to revisit the poets as the protagonists of 'the dream' that was, and became, Lyrical Ballads
Ambivalent, Double, Divided: Reading and Rereading Perry Nodelman
No full textReview of:
Matas, Carol, and Perry Nodelman. The Curse of the Evening Eye. The Ghosthunters 2. Toronto: Key Porter, 2009.
Matas, Carol, and Perry Nodelman. The Hunt for the Haunted Elephant. The Ghosthunters 3. Toronto: Key Porter, 2010.
Matas, Carol, and Perry Nodelman. A Meeting of Minds. New York: Simon, 1999.
Matas, Carol, and Perry Nodelman. Of Two Minds. 1994. New York: Simon, 1995.
Matas, Carol, and Perry Nodelman. The Proof that Ghosts Exist. The Ghosthunters 1. Toronto: Key Porter, 2008.
Nodelman, Perry. Behaving Bradley. New York: Simon, 1998.
Nodelman, Perry. A Completely Different Place. New York: Simon, 1997.
Nodelman, Perry. The Hidden Adult: Defining Children’s Literature. Baltimore: Johns Hopkins UP, 2008.
Nodelman, Perry. Not a Nickel to Spare: The Great Depression Diary of Sally Cohen. Dear Canada. Toronto: Scholastic, 2007.
Nodelman, Perry. The Same Place but Different. New York: Simon, 1995.
DOI: 10.1353/jeu.2011.000
Cerebral venous thrombosis after vaccination against COVID-19 in the UK: a multicentre cohort study
No full textA new syndrome of vaccine-induced immune thrombotic thrombocytopenia (VITT) has emerged as a rare side-effect of vaccination against COVID-19. Cerebral venous thrombosis is the most common manifestation of this syndrome but, to our knowledge, has not previously been described in detail. We aimed to document the features of post-vaccination cerebral venous thrombosis with and without VITT and to assess whether VITT is associated with poorer outcome
Brain region specific pre-synaptic and post-synaptic degeneration are early components of neuropathology in prion disease.
No full textSynaptic abnormalities, one of the key features of prion disease pathogenesis, gives rise to functional deficits and contributes to the devastating clinical outcome. The synaptic compartment is the first to succumb in several neurodegenerative diseases linked with protein misfolding but the mechanisms underpinning this are poorly defined. In our current study we document that a focal intrahippocampal injection of the mouse-adapted 22L scrapie strain produces a complex, region-specific pathology in the brain. Our findings reveal that early synaptic changes in the stratum radiatum of the hippocampus, identical to those observed with the ME7 strain, occur when 22L strain is introduced into the hippocampus. The pathology was defined by degenerating Type I pre-synaptic elements progressively enveloped by the post-synaptic density of the dendritic spine. In contrast, the pathology in the cerebellum suggested that dendritic disintegration rather than pre-synaptic abnormalities dominate the early degenerative changes associated with the Purkinje cells. Indeed, both of the major synaptic inputs into the cerebellum, which arise from the parallel and climbing fibers, remained intact even at late stage disease. Immunolabeling with pathway selective antibodies reinforced these findings. These observations demonstrate that neuronal vulnerability to pathological protein misfolding is strongly dependent on the structure and function of the target neurons
Commentary: Water: A Preventable Disaster
No full textEditor-in-Chief\u27s Note: The Texas Water Journal invited Texas state Senator Charles Perry, Chair of the Senate Committee on Water and Rural Affairs, to share his thoughts on the role of water in the coming 87th legislative session of the Texas Legislature. In the upcoming legislative session, Senator Perry said Texas will be navigating the continuing COVID-19 pandemic, the road to recovery and continuing water supply development. In the commentary, Senator Perry addresses how leveraging technology, public-private partnerships, and regulations will encourage the creation of new water sources while also expanding existing strategies. The opinion expressed in this commentary is the opinion of the individual author and not the opinion of the Texas Water Journal or the Texas Water Resources Institute.
Citation: Perry C. 2020. Commentary: Water: A Preventable Disaster. Texas Water Journal. 11(1):172-173. Available from: https://doi.org/10.21423/twj.v11i1.7129
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