1,721,865 research outputs found
Quantitative research assessment: using metrics against gamed metrics-comment
No full text: In this letter to the Editor, the author reports his comment on the review article entitled. "Quantitative research assessment: using metrics against gamed metrics" published in this Journal
A historical perspective on milestones in multiple myeloma research
Full text linkThe first well-documented case of multiple myeloma was reported in 1844 by Samuel Solly. In this article, the author presents a historical review of the disease. In particular, the review is focused on the main steps, including the definition of Bence Jones proteinuria, the characterization of tumoral plasma cells and serum globulins, and the fundamental contribution of Jan Waldenstrom. Finally, treatment of multiple myeloma, as well as the development of new agents, is discussed
Morphology and art in the work of Lelio Orci
No full text: Lelio Orci, chairman of the Department of Morphology at the University of Geneva Medical School in Switzerland, was one of the most eminent morphologists of the last century, author of fundamental contributions to the study of microanatomy, especially regarding the ultrastructure of the endocrine pancreas and of the molecular mechanisms of cell secretion. In his work, Orci transformed EM-ultrastructure into a creative art form. The aim of this article is to demonstrate, through a few examples of the scientific work of this extraordinary scientist the reality of this assertion
The chemical nature of the factor responsible for embryonic induction. An historical overview
No full textA double-edged sword in tumor angiogenesis and progression. Dual roles of mast cells, macrophages, and neutrophils
No full textInflammatory cells act in concert with tumor cells, stromal cells, and endothelial cells to create an environment that is critical for the survival, development, and diffusion of the tumor. Under a variety of conditions, inflammatory cells are capable of polarization under their tumoricidal (growth arresting) or tumorigenic (growth promoting) forms. In this context, two major subsets of mast cells, macrophages, and neutrophils, have been described. This article is focused on the description of these different sub-populations and to the analysis of arrays of common and specific mediators involved in their action in the context of tumor growth. Different databases, including PubMed/MEDLINE, Scopus, and Google Scholar, were searched to review and analyze relevant literature concerning the different sub-populations of mast cells, macrophages, and neutrophils, and arrays of common and specific mediators involved in their action in the context of tumor growth.The analysis of the literature data confirm that the microenvironment can inhibit tumor growth and suppress or revert the malignant phenotype. Incorrect signals from the microenvironment can lead to initiation and promotion of neoplastic transformation of normal cells, and once tumor is formed, it modifies the stroma and initiates an inflammatory reaction and an immune response
Is angiogenesis essential for the progression of hematological malignancies or is it an epiphenomenon ?
No full textThe contribution of Harold F. Dvorak to the study of tumor angiogenesis and stroma generation mechanisms
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