4,267 research outputs found
Epistasis in a fitness landscape defined by antibody-antigen binding free energy
No full textData and code used to generate figures for "Epistasis in a fitness landscape defined by antibody-antigen binding free energy". This code is correct at time of submission, but will be updated at https://github.com/rhys-m-adams/epistasis_4_4_20This code attempts to quantify the level of epistasis in CDR1H and CDR3H domains of the 4-4-20 fluorescein binding antibody.The readme details how to run the code, but briefly, install python 3.6, pymol as a command line argument, Numpy, scipy, matplotlib, emcee, cvxopt, svgutils, and pybeeswarm, then run the make_figs.sh script
smoothDE: a smooth density estimator with good performance
No full textProbability density estimation is the problem of inferring an underlying probability from a sampling of points. This study introduces smoothDE, an algorithm that uses Bayesian Field Theory to optimize non-parametric density estimation. smoothDE deterministically finds an optimal density function based on the probability of observed data, subject to a smoothing constraint and its associated prior probability. smoothDE's predicted densities have almost universally lower Kullback-Leibler divergences from simulated Gaussian Mixtures densities when compared to similar Bayesian Field Theory methods and Kernel Density Estimators. smoothDE was even able to outperform a specialized Bayesian Gaussian Mixture density estimator at lower samplings. smoothDE's ability to quickly fit arbitrary densities allowed it to be used as a preprocessing step for classification algorithm, in certain cases boosting classifier performance
Henry Adams, Jr. letter to father, February 5, 1952
No full textThis letter was written by Henry Adams Jr. to his father, Henry Adams, expressing his feelings and experiences during his time in the army. Junior, as he was called in the family, had been posted to Alaska after his basic Army training, and assigned to an otherwise all-white company.
In this three-page letter written on decorative notepaper, Junior writes about his army experiences, and says that he feels like Jackie Robinson, a test case for integrated units in the military. The United States Army was not integrated during World War II; African Americans and whites served in separate units. Harry Truman issued an executive order intended to end segregation in the Army in January of 1948, and letters such as this indicate that the executive order took some time to become fully effective
Henry Adams, Jr. letter to family, December 1951
No full textThis letter was written by Henry Adams Jr. to his family back home, expressing his feelings and experiences during his time in the army. Junior, as he was called in the family, had been posted to Alaska after his basic Army training, and assigned to an otherwise all-white company.
In this one-page letter written on pink paper, he describes the reaction of his fellow servicemen to his presence on post He feels the other soldiers do not appreciate having a skilled African American among them, as all the others are either manual laborers or cooks, while he is a watch repairman. He is still awaiting his assignment within the company. The letter is undated but the envelope is post-marked December 9, 1951.
The United States Army was not integrated during World War II; African Americans and whites served in separate units. Harry Truman issued an executive order intended to end segregation in the Army in January of 1948, and letters such as this indicate that the executive order took some time to become fully effective
Charles H. Adams letter to Anna Pemberton, April 18, 1904
No full textShort note from a librarian, archivist, historian or records administrator Charles H. Adams, stationed at the Adams Building in Boston, Massachusetts, in response to an inquiry from Ms. Anna Pemberton -- working on a "Life" (or biography) of Benjamin Lundy -- as to whether the collection contains correspondence between Lundy and John Quincy Adams. Charles Adams responds to Pemberton, informing her that an investigation has been undertaken, and, 33 letters are available for her research between Lundy and John Quincy Adams. Benjamin Lundy (1789-1839) was a prominent Quaker abolitionist best known for his development of abolitionist periodicals. His Genius of Universal Emancipation was first published in 1821 from his home in Mt. Pleasant, Ohio, and enjoyed a wide circulation across the antebellum United States. In the 1820s, the young William Lloyd Garrison came to work for The Genius. Benjamin Lundy traveled widely seeking subscriptions to The Genius, giving talks about the anti-slavery movement, and observing and documenting the conditions of enslaved people across the Americas. He was also involved in the establishment of freed slave colonies in Mexico
Interviews with Robert Lee and Philip Rhys Adams, March 9, 1985 and Phoebe Craig Macbeth, May 10, 1986 [Part 1]
No full textCassette recordingInterviews conducted by Bennard Perlman with Robert Lee and Philip Rhys Adams on March 9, 1985, and Phoebe Craig Macbeth on May 10, 1986, for Perlman's book, "The Lives, Loves and Art of Arthur B. Davies." Lee is a Philadelphia collector of Davies. Macbeth is the granddaughter of W. Macbeth, a New York gallery owner. Marder is the granddaughter of Davies.
Interview with Macbeth is continued on DAM_ABD_AUD_13B (http://cdm16397.contentdm.oclc.org/cdm/ref/collection/p16397coll21/id/7343)
SCHOOL ATLAS TO ADAMS' GEOGRAPHY Containing the following MAPS 1. The World, 2. N. America, 3. U. States, 4. New England, 5. S. America, 6. Europe, 7. England, 8. Asia, 9. Africa
No full textAtlas to accompany Adams' "Geography; or, A description of the world". The 1818 (3rd) edition was viewed and no indication of engraver or cartographer was indicated
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No full textThe Cuff-type instrument is attached to the box-foot by a square pillar, which supports the body-tube, stage and the mirror. Focusing is by rackwork that moves the stage. The drawer includes accessories (objective lenses, Lieberkuhn reflector, fish plate, stage forceps, and brass slider.) The whole instrument fits into a pyramid-shaped mahogany case upon removing the body-tube. The instrument is very similar to the "Improved Double and Single Microscope," featured in Adams' Essays on the Microscope (1787). Signed: G. Adams No 60 Fleet Street London
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