1,721,076 research outputs found
Hormona antimülleriana: la hormona testicular fetal que mejor refleja la reserva ovárica adulta
Full text linkFil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentin
Différenciation sexuelle
No full textFil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentin
Next-Generation Sequencing as First-Line Diagnostic Test in Patients With Disorders of Sex Development?
Full text linkDisorders of sex development (DSD) are a group of highly heterogeneous disorders presenting mainly at birth or at pubertal age, characterized by discordance between chromosomal, gonadal, and/or genital sex. Newborns usually present with ambiguous genitalia while adolescents present with atypical or downright absent pubertal development (1)...Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentin
Translational research in medicine
No full textMedicina Traslacional: ¿qué significa? La palabra “traslacional” es un neologismo que no figura en el diccionario de la lengua española de la Real Academia. Es un anglicismo, originado en la palabra “translation”, que significa “traducción”. Deberíamos entonces decir “Medicina Traduccional”. Pero, aun así, ¿a qué nos referimos? La Medicina Traslacional o Traduccional es una definición emergente para referirse a la disciplina que aplica al campo de la medicina los principios de la investigación traslacional o traduccional, o sea la traducción en aplicaciones concretas de los descubrimientos realizados como consecuencia de la investigación de teorías o hipótesis científicas.Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentin
Early orchiopexy to prevent germ cell loss during infancy in congenital cryptorchidism
Full text linkCryptorchidism is a problematic topic, beginning with its meaning. Although, by etymology, it refers to “hidden testes,” the term cryptorchidism has been widely used to describe testes that are not in their normal position in the scrotum. The strictest terminology distinguishes between bilaterally absent testes (“anorchia”), the absence of one testis (“monorchia”), the existence of one or both testes in a position along (“undescended or maldescended testes”) or outside (“ectopic testes”) the normal pathway of descent from the abdominal cavity, and their spontaneously changing position back and forth from the scrotum to the inguinal canal (“retractile testes”). Although these rigorous definitions can only be applied after a definite diagnosis is made, most physicians use the terms cryptorchidism and ectopic or undescended testes to refer loosely to the absence of the testes in the scrotum, even before ascertaining their existence in the case of nonpalpable gonads. It is therefore not surprising that major controversies remain surrounding the epidemiology, the pathogenesis, the diagnosis, the long-term consequences, and the treatment of cryptorchidism. Moreover, conclusions based on inadequate study design have added to the confusion.Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentin
The Role of Androgen Signaling in Male Sexual Development at Puberty
Full text linkPuberty is characterized by major changes in the anatomy and function of reproductive organs. Androgen activity is low before puberty, but during pubertal development, the testes resume the production of androgens. Major physiological changes occur in the testicular cell compartments in response to the increase in intratesticular testosterone concentrations and androgen receptor expression. Androgen activity also impacts on the internal and external genitalia. In target cells, androgens signal through a classical and a nonclassical pathway. This review addresses the most recent advances in the knowledge of the role of androgen signaling in postnatal male sexual development, with a special emphasis on human puberty.Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentin
Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release
Full text linkThe mammalian testis is formed by 2 morphologically and functionally distinct compartments: the seminiferous tubules and the interstitial tissue. The seminiferous tubules contain the germ cell population, originating the male gametes in the adult, and the somatic Sertoli cell lineage. In the interstitial tissue lies the Leydig cell population, responsible for androgen secretion, amid connective tissue with blood vessels and nerves. The structure and function of the testes show remarkable changes during postnatal life, especially during pubertal maturation, driven by androgens. One notorious transformation occurs within the seminiferous tubules: prepubertal spermatogenesis, limited to spermatogonial mitoses, switches to adult spermatogenesis, where spermatogonial proliferation is followed by 2 successive meiotic divisions and spermatid maturation leading to the production and release of spermatozoa. This gonad-specific biologic process depends essentially on the support given by mature Sertoli cells. While molecules coming from the blood vessels present in the interstitial tissue have free access to spermatogonia, meiotic and postmeiotic germ cells are completely isolated from blood-borne substances. This is mainly due to the development of the blood-testis barrier (BTB) during pubertal maturation.Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentin
Mini-puberté et vraie puberté: différences au niveau de la fonction testiculaire
Full text linkThe ontogeny of the hypothalamic-pituitary-gonadal axis is particularly characterised by incomplete functional maturation in utero and during early postnatal life, followed by functional regression and partial quiescence during childhood, and subsequently by final complete maturation during puberty. This review addresses the distinctive features of testis developmental physiology – especially in the seminiferous tubule compartment – which explain the differences observed in testicular function and its disorders between the early postnatal activation period – which many authors call “mini-puberty” – and canonical puberty.L’ontogenèse de l’axe hypothalamo-hypophyso-gonadique est caractérisée par un développement fonctionnel incomplet pendant la vie fœtale et les premiers mois de la vie postnatale, suivi par une régression fonctionnelle et une quiescence partielle pendant l’enfance, et finalement par une maturation complète au cours de la puberté. Cette revue analyse les caractéristiques distinctives de la physiologie du développement testiculaire – et spécialement celles des tubes séminifères – qui peut expliquer les différences observées au niveau de la fonction testiculaire et ses anomalies entre la période d’activation postnatale – appelée « mini-puberté » par certains auteurs – et la vraie puberté.Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentin
Steroid receptors in the testis: implications in the physiology of prenatal and postnatal development and translation to clinical application
Full text linkThe testes are the main source of sex steroids in the male, especially androgens and to a lesser extent estrogens. In target cells, steroid hormones typically signal after binding to intracellular receptors, which act as transcription factors. Androgens and estrogens have ubiquitous functions in peripheral organs, but also have paracrine actions within the gonads where they are far more concentrated. The levels of steroid production by the testes vary throughout fetal and postnatal development: they are high in intrauterine life and in the first months after birth, then they decline and are almost undetectable in childhood and increase again during puberty to attain adult levels. The expression of the androgen and estrogen receptors also depict specific ontogenies in the various testicular cell types. The combination of intratesticular steroid concentration with the pattern of expression of the steroid hormone receptors defines androgen and estrogen action on Sertoli, germ and Leydig cells. Here, we review the ontogeny of expression of the androgen and estrogen receptors in the testis, its impact on testicular physiology during prenatal and postnatal development, as well as its implication on the pathophysiology of different disorders affecting gonadal function throughout life.Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentin
Disorders of sex development
No full textFil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Houk, Christopher P.. No especifíca;Fil: Witchel, Selma. No especifíca;Fil: Lee, Peter A.. No especifíca
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