1,721,007 research outputs found
The 20th century: The maelstrom of progress
No full text'The last decades of the 19th century were occupied with the detailed study of the morphology of tumours, the separation of the varieties of disease, the elucidation of histogenesis and the writing of the natural history of malignant diseases. The twentieth century opens as the experimental era.... It seems likely to become noteworthy as the period of specific aetiological investigations which promise to widely separate many neoplastic diseases formerly held to be closely related. It may, thereby, prove to be the era of successful therapeutics and prophylaxis'.</p
Beyond the second millennium
No full text«This is not the end, nor even the beginning of the end, but it is certainly the end of the beginning.» - Winston S. Churchil
Educational section: risk analysis in surgical oncology-part I: concepts and tools
No full textAll clinical procedures invoke risk. Many interventions in cancer management carry a particularly high element of risk, expressed through morbidity and premature death. Formal risk analysis is a discipline which is fundamental to engineering, to finance, to the airline industry and many other sectors of public life. Clinical risk analysis involves risk prediction, risk management and risk avoidance. Risk analysis is rarely invoked or taught in the clinical sciences, and management appraisals on individual patients almost never include a formal estimate of risk. Clinical decisions tend to be guided by qualitative judgements, and by the personality interactions of patients and clinicians. A formal evaluation of risk on a case by case and procedural basis might reduce morbidity and cost in surgical oncology practice. This article introduces the concepts, the spectrum and history of risk analysis and the tools for risk prediction
The importance of heterogeneity in tumor pathology.
No full textHeterogeneity of cell, tissue, and tumor genotype, form, and function confounds clinicopathologic research and therapeutic strategies. Its significance and importance usually are underestimated and underreported, and there is no consistent statistical or biomathematical framework for its interpretation. New technologies for the quantitative study of pathology specimens and a growing awareness of the clinical importance of biodiversity within individual tumors and populations of tumors herald new approaches to the problems posed by dynamic structural and functional complexity in human tumors
Risk analysis in surgical oncology - Part II: Risk and the practising surgeon
No full textSurgery for cancer imparts a high risk of morbidity and premature mortality. Inappropriate decisions and inadequate information can have a profound effect on the outcome of interventions. A formal process of appraisal of options, aided by modern information technology, may help rationalize and improve management stratagems and reduce risk. Rigorous and obsessional attention to risks in clinical and surgical procedures and processes, including the selection and training of surgeons, process and human reliability analysis, and ubiquitous error reduction strategies will also help minimize risk. These approaches will have a significant bearing on familiar surgical practice and will need to be extended across the multidisciplinary spectrum of cancer care. (C) 2000 Harcourt Publishers Ltd
Worldwide publication of the EJSO: The IDEAL way forward
No full textInternet publication is with us. Over the past 3 years, the Editorial Board of the European Journal of Surgical Oncology has sought to harness the Information Technology revolution to the objectives of your journal. To this end, we have published a series of articles to educate our readers about the form and opportunities of the electronical information age for surgical oncologists, against a background of rapidly evolving technology
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