177,154 research outputs found
PEODDN (Porokeratotic eccrine ostial and dermal duct naevus) sistematizzato lungo le linee di Blaschko
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Inflammatory linear verrucous epidermal nevus (ILVEN) and psoriasis in a child?
No full textA male infant, whose father was affected by psoriasis, was first seen in our department at 1 month of life for a "bipolar" seborrheic dermatitis, that resolved without treatment at 7 months of age.
At 15 months of life, the child returned for an eruption of erythematous and finely scaling papules disposed in a linear, band-like fashion over the left part of the body, involving the volar surface of the arm, the left leg from the inguinal fold to the ankle, and the abdomen and thorax, where they assumed the typical S-shaped curve following Blaschko lines. The lesions were not itchy. A punch biopsy of a linear lesion on the left arm was performed. Histopathologic examination showed parakeratosis with absence of the granular layer, mild acanthosis with papillomatosis, necrosis of single keratinocytes, and a mild lymphohistiocytic infiltrate located in the superficial dermis. A tentative diagnosis of lichen striatus was made. After a few days, a diffuse eruption of pinpoint-sized, lenticular, erythemato-desquamative lesions occurred on the trunk and limbs, with the typical clinical appearance of guttate psoriasis (Fig. 1). The child was in good general condition, and routine blood tests were within the normal range. No triggering factor was found. Treatment with emollients led to the resolution of the psoriatic lesions within 4 months; in contrast, the linear lesions were not grossly changed by this treatment and just appeared more flattened.
The child was seen again at 3 years of age: the linear papular lesions on the left side of the body were unchanged, and stilt asymptomatic. The previous diagnosis of lichen striatus was then changed to linear psoriasis.
The clinical picture remained unchanged until the age of 10 years, when the child presented with eruptive, small patches of psoriasis on the trunk and abdomen. Concomitant with this eruption, the child experienced a sudden change in the clinical aspect of the linear lesions, that became more inflammatory, assuming a verrucous and, in some cases, crusting aspect; intense itching developed. Two punch biopsies of a linear lesion on the left leg were performed. The lesion specimen showed orthohyperkeratosis, with the presence of the granular layer, and mild dilation of the vessels of the superficial plexus, with edema and a discrete mononuclear infiltrate. The second specimen showed mild hyperkeratosis with neutrophil microabscesses in the stratum corneum; in a single portion of the specimen, a mononuclear infiltrate in the mid-dermis with edema, exoserosis, and exocytosis was found. Based on the clinical course and on the histopathologic aspect, we made a diagnosis of inflammatory linear verrucous epidermal nevus (ILVEN) with concurrent psoriasis. Treatment with calcipotriol ointment every day for 2 months cleared the nonlinear psoriatic lesions. The linear lesions partially improved (Fig. 2), but did not clear (Fig. 3). Further treatment with clobetasol propionate every day for 1 month improved the itching, but left the linear lesions unchanged
Skin dimpling as a consequence of amniocentesis
No full textNo reports of cutaneous lesions after amniocentesis have been published after the advent of real-time ultrasonography. Two infants with multiple skin dimpling caused by needle puncture during fetal life are described. They had pitted scars on the thighs and abdomen that were not associated with internal injury. Both mothers had undergone a diagnostic amniocentesis at the beginning of the second trimester of pregnancy. Real-time ultrasound monitoring of amniocentesis has not completely eliminated the risk of needle puncture scarring of the fetus
Resveratrol derivatives and their role as potassium channels modulators
No full textA series of stilbenoid analogues of resveratrol (trans-3,4',5-trihydroxystilbene) with a stilbenic or a bibenzylic skeleton have been prepared by partial synthesis from resveratrol and dihydroresveratrol. The synthesized compounds have been evaluated for their ability to modulate voltage-gated channels
Lichen striatus -- a chameleon : An histopathological and immunohistological study of forty-one cases
No full textLichen striatus (LS) is an uncommon dermatosis that generally affects children. The histopathology of LS often shows a polymorphic epidermal reaction process of variable lichenoid and spongiotic changes having no specific histopathological criteria or simulating other diseases. In the present study, we have evaluated the histopathological features of 41 biopsy specimens and the immunohistochemical aspects of 10 cases of LS. In 50% of the cases, we found histopathological and immunopathological features constantly present and allowing a correct diagnosis. In 9 cases, the histopathology was not specific, and in 10 cases, a clear differentiation from other diseases was not possible. Immunohistochemical study demonstrated a CD3+ T-lymphocytic infiltration in which CD8+ cells surrounded necrotic keratinocytes and intraepidermal vesicles filled with Langerhans cells. These findings seem to corroborate the hypothesis that a somatic mutation of a keratinocytic clone could induce an autoimmune response of the host
Weighting network influence on the geometric term correction in MARSIS data inversion
No full textMars Advanced Radar for Subsurface and Ionosphere Sounding (MARSIS) is a low frequency, pulse-limited radar sounder and altimeter selected by ESA as a payload of the Mars Express mission. This work retraces the processing that leads to the extraction of parameters needed to perform the data inversion pointing out an effect caused by the weighting network application in presence of volume scattering that could jeopardize the backscattering-related geometry interpretation on a specific set of data
Ionosphere compensation and stepped frequency processing in the MARSIS experiment
No full textThis paper is addressed to the improvement of the range resolution of MARSIS (Mars Advanced Radar for Subsurface and Ionosphere Sounding) by means of a modified version of the stepped frequency processing algorithm. MARSIS is a low frequency, pulse-limited radar sounder and altimeter selected by ESA as a payload of the Mars Express mission. The ionosphere affects MARSIS operation in terms of phase distortion, attenuation and Faraday rotation. The ionosphere fine compensation is obtained according to the uniform model, allowing, with the correctly compensated data, the production of MARSIS images at higher resolution. In this way it is possible to detect hidden interfaces never seen before due to MARSIS coarse vertical resolution. © 2011 IEEE
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