3,469 research outputs found
Robust inference of cooperative behaviour of multiple ion channels in voltage-clamp recordings
No full textRecent experimental studies have shed light on the intriguing possibility
that ion channels exhibit cooperative behaviour. However, a comprehensive
understanding of such cooperativity remains elusive, primarily due to
limitations in measuring separately the response of each channel. Rather, only
the superimposed channel response can be observed, challenging existing data
analysis methods. To address this gap, we propose IDC (Idealisation,
Discretisation, and Cooperativity inference), a robust statistical data
analysis methodology that requires only voltage-clamp current recordings of an
ensemble of ion channels. The framework of IDC enables us to integrate recent
advancements in idealisation techniques and coupled Markov models. Further, in
the cooperativity inference phase of IDC, we introduce a minimum distance
estimator and establish its statistical guarantee in the form of asymptotic
consistency. We demonstrate the effectiveness and robustness of IDC through
extensive simulation studies. As an application, we investigate gramicidin D
channels. Our findings reveal that these channels act independently, even at
varying applied voltages during voltage-clamp experiments. An implementation of
IDC is available from GitLab
Happy Hour with Robin Sacks
No full textRobin Sacks is the author of Get Off My Bus!: How to Get Clarity, Get in the Driver\u27s Seat, and Get Moving in Your Life! Introduction by Kristen Kuhlman, LSW, LHNA, MBA/HCM DHA Candidate
Robust Inference of Cooperative Behavior of Multiple Ion Channels in Voltage-Clamp Recordings
No full textPublic management : Reinventing Government: a symposium. by Robin Butler
No full texttag=1 data=Public management : Reinventing Government: a symposium. by Robin Butler
tag=2 data=Butler, Robin
tag=3 data=Public Administration,
tag=4 data=72
tag=5 data=2
tag=6 data=Summer 1994
tag=7 data=263-270.
tag=8 data=MANAGEMENT%PUBLIC SERVICE
tag=10 data=The author indicates how the major themes of the book [Reinventing Government] can be seen to correspond with many of the recent management initiatives in UK government.
tag=11 data=1994/6/8
tag=12 data=94/0490
tag=13 data=CABThe author indicates how the major themes of the book [Reinventing Government] can be seen to correspond with many of the recent management initiatives in UK government
Robin Becker, 16th Annual ODU Literary Festival
No full textRobin Becker is the author of Giacometti’s Dog, published in 1990 by the University of Pittsburgh Press. Her previous books are Backtalk and Personal Effects, both published by Alice James Books She has received fellowships in poetry from the Massachusetts Artists Foundation and the National Endowment for the Arts. Her poems appear in many journals including Agni, The American Poetry Review, The Kenyon Review, and Ploughshares. She has published book reviews in Belles Lettres, The Boston Globe, The Boston Review, Prairie Schooner and The Women’s Review of Books She teaches in the Program in Writing and Humanistic Studies at Massachusetts Institute of Technology. This year she is Visiting Poet at Pennsylvania State University. Robin Becker serves as Poetry Editor for The Women’s Review of Books and as a member of the board of directors of Associated Writing Programs
Author Robin Silbergleid reads from her memoir "Texas girl," and her soon to be published book of poetry, "The baby book" at the Michigan Writers Series
No full textAuthor Robin Silbergleid reads from her memoir "Texas girl," and her soon to be published book of poetry, "The Baby Book." Introductory remarks are provided by MSU Professor Telaina Eriksen and MSU Librarian Michael Rodriguez. Part of the MSU Libraries' Michigan Writers Series. Held at the MSU Main Library and sponsored by the MSU Department of English and the Center for Gender in Global Context
Writer Robin Lippincott reads from novel In the Meantime
No full textIncludes descriptive metadata provided by producer in MP3 file: "Listen to writer Robin Lippincott read from his new novel In the Meantime, which tracks the intertwined lives of three friends for six decades. Lippincott is also the author of Mr. Dalloway. The reading was part of the Gertrude Vanderbilt and Harold S. Vanderbilt Visiting Writers Program at Vanderbilt University. It was recorded on Oct. 31, 2007.
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