2,115 research outputs found
Applicazione della Tecnologia AAV-CRISPR / Cas9 come Terapia genica su neuroni differenziati da iPSC derivanti da pazienti con mutazioni in MECP2,FOXG1,CDKL5,IQSEC2, e PCDH19
No full textGeographical distribution of cystic fibrosis carriers as population genetic determinant of COVID-19 spread and fatality in 37 countries
No full textCOVID-19 has shown a relevant heterogeneity in spread and fatality among countries together with a significant variability in its clinical presentation, indicating that host genetic factors may influence COVID-19 pathogenicity. Indeed, subjects carrying single pathogenic variants of the Cystic Fibrosis (CF) Transmembrane Conductance Regulator (CFTR) gene – i.e. CF carriers – are more susceptible to respiratory tract infections and are more likely to undergo severe COVID-19 with higher risk of 14-day mortality. Given that CF carrier prevalence varies among ethnicities and nations, an ecological study in 37 countries was conducted, in order to determine to what extent the diverse CF carrier geographical distribution may have affected COVID-19 spread and fatality during the first pandemic wave. The CF prevalence in countries, as indicator of the geographical distribution of CF carriers, significantly correlated in a direct manner with both COVID-19 prevalence and its Case Fatality Rate (CFR). In a regression study weighted for the number of tests performed, COVID-19 prevalence positively correlated with CF prevalence, while CFR correlated with population percentage older than 65-year, cancer and CF prevalence. Multivariate regression model also confirmed COVID-19 CFR to be associated with CF prevalence, after adjusting for elderly, cancer prevalence, and weighting for the number of tests performed. This study suggests a putative contribution of population genetics of CFTR in understanding the spatial distribution of COVID-19 spread and fatality
GEOMETRY IN MOTION. BETWEEN RESEARCH, EDUCATION AND OUTREACH
No full textIn this paper, we will explore the connections between mathematics and dance, understood as a
movement of the body itself. The idea is to use the human body and the space that surrounds it in
order to introduce important concepts of Geometry and, in general, Mathematics. More precisely,
building on the experimentations carried out in 2015, we will discuss how body cognition can be a
fundamental tool in communicating and teaching maths
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