188 research outputs found
A gazetteer and summary of French pottery imported into Scotland c. 1150 to c. 1650 a ceramic contribution to Scotland's economic history Ceramic Resource Disc 3
No full textThe proposal for a series of published inventories, by countries, of all the imported medieval and post medieval pottery recovered from excavations and field walking in Scotland, was advanced on the final day of the Medieval Pottery Research Group’s conference held in Edinburgh in May 2001. Taking on the roll of creating a gazetteer and catalogue of French pottery in Scotland, it was the authors aim to build on the pioneering work of John Hurst and other medieval ceramicists and in the process make a contribution to the ongoing research on identifiable medieval and post-medieval ceramics traded around the North and Irish Sea
Victor A. McKusick, MD and The Osler Medical Service – Firm System Threads Between Baltimore and Maine: The 15th Annual McKusick Lecture
No full textCombining clinical, pathological, and demographic factors refines prognosis of lung cancer: a population-based study.
No full textIn the treatment of lung cancer, an accurate estimation of patient clinical outcome is essential for choosing an appropriate course of therapy. It is important to develop a prognostic stratification model which combines clinical, pathological and demographic factors for individualized clinical decision making.A total of 234,412 patients diagnosed with adenocarcinomas or squamous cell carcinomas of the lung or bronchus between 1988 and 2006 were retrieved from the SEER database to construct a prognostic model. A model was developed by estimating a Cox proportional hazards model on 500 bootstrapped samples. Two models, one using stage alone and another comprehensive model using additional covariates, were constructed. The comprehensive model consistently outperformed the model using stage alone in prognostic stratification and on Harrell's C, Nagelkerke's R(2), and Brier Scores in the whole patient population as well as in specific treatment modalities. Specifically, the comprehensive model generated different prognostic groups with distinct post-operative survival (log-rank P<0.001) within surgical stage IA and IB patients in Kaplan-Meier analyses. Two additional patient cohorts (n = 1,991) were used as an external validation, with the comprehensive model again outperforming the model using stage alone with regards to prognostic stratification and the three evaluated metrics.These results demonstrate the feasibility of constructing a precise prognostic model combining multiple clinical, pathologic, and demographic factors. The comprehensive model significantly improves individualized prognosis upon AJCC tumor staging and is robust across a range of treatment modalities, the spectrum of patient risk, and in novel patient cohorts
Inositol phosphate generation in the heart : mechanisms and functional relevance
No full textContains only introductory pages. Deposited with permission of the author. © 2000 Scot J. Matkovich.The studies described in this thesis have used principally the rat neonatal cardiomyocyte (NCM) model to investigate previously unresolved questions regarding inositol phosphate signalling in the heart. Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) is known to be an arrhythmogenic molecule in the setting of cardiacischaemia and subsequent reperfusion, but the mechanisms responsible for its enhanced generation in pathological circumstances, as well as those suppressing its generation during phospholipase C (PLC)-coupled receptor stimulation under physiological conditions, have not been characterised. [3H]Inositol-labelling in combination with anion-exchange high performance liquid chromatography (HPLC)was used to gain an accurate picture of the changes in various [3H]InsP isomers induced by PLC stimulation
Combretastatin A4 phosphate: a novel vascular disrupting agent
No full text Combretastatin A4 phosphate (CA4P) is the lead compound of a relatively new class of agents termed vascular disrupting agents that target existing tumor blood vessels. Rapid tumor blood flow shutdown has been demonstrated in preclinical models and patients by various techniques such as dynamic contrast-enhanced MRI, perfusion computed tomography and PET scans following CA4P infusion. CA4P typically induces rapid tumor necrosis in the center of the tumor and leaves a rim of viable cells in the periphery. In oncology, CA4P does not appear to be that active by itself, but may be more efficacious when combined with chemotherapy, antiangiogenic therapy and radiation therapy. Studies are currently underway, which combine CA4P with antiangiogenic agents. Side effects have included hypertension, tumor pain and occasional cardiovascular toxicity, without any significant myelosuppression or disabling systemic symptoms. The utility of CA4P for conditions other than cancer, which involves neovascularization such as macular degeneration, is also being explored. </jats:p
AIDS-Associated Burkitt’s Lymphoma
No full textToday AIDS-associated Burkitt’s lymphoma (BL) and atypical BL remain a significant cause of morbidity and mortality in HIV-infected patients the world over and especially in sub-Saharan Africa. While the overall incidence of BL appears to be stable in the backdrop of HIV infection in the current antiretroviral therapeutic era, there is clearly a trimodal age peak that is now observed and is clearly reflective of AIDS association, a predominance of males persists, and improved understanding of pathogenic mechanisms may shed new light on the disease process especially in HIV-infected patients. Importantly, it is clinically well recognized that it is no longer appropriate to consider AIDS-related non-Hodgkin’s lymphoma as a single disease entity and rather treatment of AIDS lymphoma needs to be tailored to lymphoma subtype. While intensive therapeutic strategies in the western world are clearly improving outcome, in AIDS epicenters of the world and especially sub-Saharan Africa more pragmatic and risk-adapted approaches are clearly needed. We are also likely entering the era of viral-targeted therapeutic approaches that may be impactful in resource-challenged areas of the world and provide new strategies for disease prevention altogether
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