50,940 research outputs found
Letter from D. E. Wilson to John T. Reid, Atlantic Coast Line Railroad Company, Wilmington, North Carolina, March 1918
No full textIncluded with this letter is a response from John T. Reid, Atlantic Coast Line Railroad Company with information about stock dividends
The telegraph in America. Its founders, promoters, and noted men.
No full textAdded t.-p., engraved: The telegraph in America and Morse memorial, & in memoriam William Orton. James D. Reid. Albany, N.Y., Printed for the author by Weed, Parsons and Company [n.d.]Mode of access: Internet
Surfactant protein D modulates HIV infection of both T-cells and dendritic cells
Get PDFSurfactant Protein D (SP-D) is an oligomerized C-type lectin molecule with immunomodulatory properties and involvement in lung surfactant homeostasis in the respiratory tract. SP-D binds to the enveloped viruses, influenza A virus and respiratory syncytial virus and inhibits their replication in vitro and in vivo. SP-D has been shown to bind to HIV via the HIV envelope protein gp120 and inhibit infectivity in vitro. Here we show that SP-D binds to different strains of HIV (BaL and IIIB) and the binding occurs at both pH 7.4 and 5.0 resembling physiological relevant pH values found in the body and the female urogenital tract, respectively. The binding of SP-D to HIV particles and gp120 was inhibited by the presence of several hexoses with mannose found to be the strongest inhibitor. Competition studies showed that soluble CD4 and CVN did not interfere with the interaction between SP-D and gp120. However, soluble recombinant DC-SIGN was shown to inhibit the binding between SP-D and gp120. SP-D agglutinated HIV and gp120 in a calcium dependent manner. SP-D inhibited the infectivity of HIV strains at both pH values of 7.4 and 5.0 in a concentration dependent manner. The inhibition of the infectivity was abolished by the presence of mannose. SP-D enhanced the binding of HIV to immature monocyte derived dendritic cells (iMDDCs) and was also found to enhance HIV capture and transfer to the T-cell like line PM1. These results suggest that SP-D can bind to and inhibit direct infection of T-cells by HIV but also enhance the transfer of infectious HIV particles from DCs to T-cells in vivo
D. T. Max, 36th Annual ODU Literary Festival
No full textD. T. Max is a graduate of Harvard University and a staff writer at The New Yorker. His new book, Every Love Story Is A Ghost Story: A Life of David Foster Wallace, was released in August 2012 and was a New York Times best-seller. He is also the author of The Family That Couldn\u27t Sleep: A Medical Mystery
T-duality invariant approaches to string theory
No full textPhDThis thesis investigates the quantum properties of T-duality invariant formalisms of
String Theory.
We introduce and review duality invariant formalisms of String Theory including
the Doubled Formalism. We calculate the background eld equations for the Doubled
Formalism of Abelian T-duality and show how they are consistent with those of a
conventional String Theory description of a toroidal compacti cation. We generalise
these considerations to the case of Poisson{Lie T-duality and show that the system of
renormalisation group equations obtained from the duality invariant parent theory are
equivalent to those of either of the T-dual pair of sigma-models. In duality invariant
formalisms it is quite common to loose manifest Lorentz invariance at the level of the
Lagrangian. The lack of manifest invariance means that at the quantum level one might
anticipate Lorentz anomalies and we show that such anomalies cancel non-trivially.
These represent important and non-trivial consistency checks of the duality invariant
approach to String Theory
D-branes and doubled geometry
Get PDFWe define the open string version of the nonlinear sigma model on doubled geometry introduced by Hull and Reid-Edwards, and derive its boundary conditions. These conditions include the restriction of D-branes to maximally isotropic submanifolds as well as a compatibility condition with the Lie algebra structure on the doubled space. We demonstrate a systematic method to derive and classify D-branes from the boundary conditions, in terms of embeddings both in the doubled geometry and in the physical target space. We apply it to the doubled three-torus with constant H-flux and find D0-, D1-, and D2-branes, which we verify transform consistently under T-dualities mapping the system to f-, Q- and R-flux backgrounds
Micrornas as potential epigenetic targets to restore the airway epithelium integrity in asthmatics
No full textC31 BASIC AND TRANSLATIONAL STUDIES ON THE ROLE OF THE EPITHELIUM / Thematic Poster SessionF. Moheimani, T. Williams, J. Koops, A. T. Reid, P. M. Hansbro, P. A.B. Wark, D. Knigh
MeSH term explosion and author rank improve expert recommendations
Get PDFInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
Get PDFBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
A biomimetic model reaction for the extradiol catechol dioxygenases
No full textA model reaction is described for extradiol catechol cleavage involving FeCl2 or FeCl3, 1,4,9-triazacyclononane (TACN), pyridine and dioxygen which shows similar cofactor and regio-selectivity to the extradiol catechol dioxygenases
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