1,721,030 research outputs found
Identification of antigens involved in infection of Aspergillus fumigatus and their recombinant production
No full textIdentification of antigens involved in infection of Aspergillus fumigatus and their recombinant production
No full textMultiresistant Pathogen Prevention and Diagnosis
No full textZusammenfassung Multiresistente Keime spielen im klinischen Alltag eine zunehmend bedeutsame Rolle. Dieses besonders auf Intensivstationen bzw. in Risikobereichen. Oftmals herrschen Unklarheiten bezuglich diagnostischer Screening-Indikationen und Strategien zur Vermeidung von ubertragungen mittels Hygiene- und Isolierungsma ss nahmen. Wir geben einen orientierenden uberblick uber die zur Zeit gangigen Empfehlungen und bewerten diese fur Methicillin-resistente Staphylococcusaureus-Stamme (MRSA) und multiresistente gramnegative Bakterien (MRGN). Abstract Multiresistant bacteria play an increasingly important role in everyday clinical practice. This is particularly the case in intensive care units and wards with critically ill patients. Often there is insufficient knowledge concerning diagnostic screening indications and strategies to avoid cross-transmission via infection control strategies. Hereby, we provide an orienting overview and assessment about current guidelines and recommendations with special focus on methicillin-resistant Staphylococcus aureus (MRSA) and multiresistantgramnegative bacteria (MRGN)
Vaccination approaches against opportunistic fungal infections caused by Aspergillus fumigatus.
No full textAlthough innate immunity primarily combats systemic infections of opportunistic fungi such as Aspergillus and Candida spp., acquired and protective immunoreactions were observed long ago in animal trials following sublethal systemic infections caused by viable fungi or after challenging animals with inactivated fungal cells. Based on these observations, fungal antigens should exist which mediate such protective immunoreactions and have in part already been identified. In this context, this review focuses primarily on the various approaches that have been used to identify protection-mediating Aspergillus-antigens and their rationale. Emphasis is placed on screening methods that have exploited genetic or proteomic approaches on the basis of the corresponding fungal genome projects. Thereby, a survey and description is given of the antigens so far known to be capable of inducing immune responses that protect animals against acquiring lethal systemic aspergillosis
Reduced virulence of Aspergillus fumigatus mutants after knock-out of conidial surface proteins
No full textTesting the protective properties of vaccine candidates against Aspergillus fumigatusin animal trials
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Antibacterial therapy in central nervous system infections – breakpoints versus minimal inhibitory concentrations related to body fluid levels
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