4,177 research outputs found
Gas dynamics at the micro-scale: A review of progress in hydrodynamic modelling
No full textThis paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.We review some recent developments in the modelling of non-equilibrium (rarefied) gas flows at the micro- and nano-scale using extended hydrodynamic models. Following a brief exposition of the challenges that non-equilibrium poses in micro- and nano-scale gas flows, we outline the field of extended
hydrodynamics, describing the effective abandonment of Burnett-type models in favour of high-order regularised moment equations. We then review the boundary conditions required if the conventional Navier-Stokes-Fourier (NSF) fluid dynamic model is applied at the micro scale, describing how 2nd-order Maxwelltype conditions can be used to compensate for some of the non-equilibrium flow behaviour near solid surfaces. While extended hydrodynamics is not yet widely-used for real flow problems because of its
inherent complexity, we finish with an outline of recent ‘phenomenological extended hydrodynamics’ (PEH) techniques — essentially the NSF equations scaled to incorporate non-equilibrium behaviour close to solid surfaces — which offer promise as engineering models.This work is funded in the UK by the Engineering and Physical Sciences Research Council through grants EP/F002467/1, EP/D07455X/1, EP/D007488/1 and EP/F028865/1
Analysis of the vibration of pipes conveying fluid
No full textThe dynamic equilibrium matrix equation for a discretized pipe element containing flowing fluid is derived from the Lagrange principle, the Ritz method and consideration of the coupling between the pipe and fluid. The Eulerian approach and the concept of fictitious loads for kinematic correction are adopted for the analysis of geometrically non-linear vibration. The model is then deployed to investigate the vibratory behaviour of the pipe conveying fluid. The results for a long, simply supported, fluid-conveying pipe subjected to initial axial tensions are compared with experimentally obtained results and those from a linear vibration model
The SSC of the Generalised Jahangir’s Graph Jm,k and its Algebraic Characterizations
No full textIn this article, we present important combinatorial and algebraicproperties of spanning simplicial complex (SSC) of the generalised Jahangir’sgraph Jm,k. We describe the relation to find f−vectors associatedto Δs(Jm,k) and determine the Hilbert series for the SR-ring KΔs(Jm,k).In the end, we present the associated primes of the facet ideal IF(Δs(Jm,k))and the Cohen-Macaulay characterization of the SR-ring of Δs(Jm,k).AMS (MOS) Subject Classification Codes: Primary 13-P10, Secondary 13-F20, 13-C14, 13-H10.Corresponding Author: Agha KashifKey Words: Simplicial Complexes, f-vectors, Spanning Trees, Face Ring, Hilbert Series, CohenMacaulay
To <i>JM</i> on Its 75th Anniversary
No full text This article discusses how Journal of Marketing ( JM) has influenced marketing science and practice by publishing articles on substantive topics relevant to customers, managers, organizations, markets, and society. The journal's 75th anniversary coincides with the 50th anniversary of the Marketing Science Institute (MSI). Frequently, JM and MSI have collaborated to address important substantive marketing issues identified in MSI's Research Priorities. The author highlights seminal articles on brand equity; business-to-business marketing (including sales force management); connecting marketing information, metrics, and strategy; consumer behavior; innovation, new product development. and product management; marketing orientation and capabilities; and market research, methodology and services. She also draws attention to articles that have won the Sheth Foundation/ JM Award and the H. Paul Root Award. The article describes how JM‘s knowledge dissemination is amplified by powerful social network effects. Ideas in JM articles diffuse through the business community, influencing the mind-set of managers worldwide. </jats:p
Simulating fluid flows in micro and nano devices : the challenge of non-equilibrium behaviour
No full textWe review some recent developments in the modelling of non-equilibrium (rarefied) gas flows at the micro- and nano-scale, concentrating on two different but promising approaches: extended hydrodynamic models, and lattice Boltzmann methods. Following a brief exposition of the challenges that non-equilibrium poses in micro- and nano-scale gas flows, we turn first to extended hydrodynamics, outlining the effective abandonment of Burnett-type models in favour of high-order regularised moment equations. We show that the latter models, with properly-constituted boundary conditions, can capture critical non-equilibrium flow phenomena quite well. We then review the boundary conditions required if the conventional Navier-Stokes-Fourier (NSF) fluid dynamic model is applied at the micro scale, describing how 2nd-order Maxwell-type conditions can be used to compensate for some of the non-equilibrium flow behaviour near solid surfaces. While extended hydrodynamics is not yet widely-used for real flow problems because of its inherent complexity, we finish this section with an outline of recent 'phenomenological extended hydrodynamics' (PEH) techniques-essentially the NSF equations scaled to incorporate non-equilibrium behaviour close to solid surfaces-which offer promise as engineering models. Understanding non-equilibrium within lattice Boltzmann (LB) framework is not as advanced as in the hydrodynamic framework, although LB can borrow some of the techniques which are being developed in the latter-in particular, the near-wall scaling of certain fluid properties that has proven effective in PEH. We describe how, with this modification, the standard 2nd-order LB method is showing promise in predicting some rarefaction phenomena, indicating that instead of developing higher-order off-lattice LB methods with a large number of discrete velocities, a simplified high-order LB method with near-wall scaling may prove to be just as effective as a simulation tool
Shear stress in arterial stenoses : a momentum integral model
No full textA mathematical model is developed to investigate blood flow in arterial stenoses up to Reynolds numbers of 1000. The approach is based on Thwaites' method, normally used to treat laminar boundary layer development over a body in a freestream. The model is applicable to any axisymmetric stenosis geometry in all laminar physiological flow regimes, has a minimum of externally input parameters and is implemented as a short program on a personal computer. Maximum bounds on the expected errors are derived by comparison with known results from Poiseuille flow in a pipe. Agreement with shear stresses reported by other researchers using computational fluid dynamics is within 13% rms. The method has been specifically designed to be a useful predictive tool for biomedical investigators
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
No full text\ua9 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Studies showed that JM-20, a benzodiazepine-dihydropyridine hybrid molecule, protects against rotenone and 6-hydroxydopamine neurotoxicity. However, its protective effects against cytotoxicity induced by endogenous neurotoxins involved in Parkinson’s disease (PD) pathogenesis have never been investigated. In this study, we evaluated the ability of JM-20 to inhibit alpha-synuclein (aSyn) aggregation. We also evaluated the interactions of JM-20 with aSyn by molecular docking and molecular dynamics and assessed the protective effect of JM-20 against aminochrome cytotoxicity. We demonstrated that JM-20 induced the formation of heterogeneous amyloid fibrils, which were innocuous to primary cultures of mesencephalic cells. Moreover, JM-20 reduced the average size of aSyn positive inclusions in H4 cells transfected with SynT wild-type and synphilin-1-V5, but not in HEK cells transfected with synphilin-1-GFP. In silico studies showed the interaction between JM-20 and the aSyn-binding site. Additionally, we showed that JM-20 protects SH-SY5Y cells against aminochrome cytotoxicity. These results reinforce the potential of JM-20 as a neuroprotective compound for PD and suggest aSyn as a molecular target for JM-20
Gas dynamics at the micro-scale : a review of progress in hydrodynamic modelling
No full textWe review some recent developments in the modelling of non-equilibrium (rarefied) gas flows at the micro- and nano-scale using extended hydrodynamic models. Following a brief exposition of the challenges that non-equilibrium poses in micro- and nano-scale gas flows, we outline the field of extended hydrodynamics, describing the effective abandonment of Burnett-type models in favour of high-order regularised moment equations. We then review the boundary conditions required if the conventional Navier-Stokes-Fourier (NSF) fluid dynamic model is applied at the micro scale, describing how 2nd-order Maxwell- type conditions can be used to compensate for some of the non-equilibrium flow behaviour near solid surfaces. While extended hydrodynamics is not yet widely-used for real flow problems because of its inherent complexity, we finish with an outline of recent ‘phenomenological extended hydrodynamics’ (PEH) techniques — essentially the NSF equations scaled to incorporate non-equilibrium behaviour close to solid surfaces — which offer promise as engineering models
Uterine transplantation: a promising surrogate to surrogacy?
No full textUterine transplantation: a promising surrogate to surrogacy?
Grynberg M1, Ayoubi JM, Bulletti C, Frydman R, Fanchin R.
Author information
Abstract
Infertility due to the inability of the uterus to carry a pregnancy ranks among the most unresolved issues in reproductive medicine. It affects millions of women worldwide who have congenital or acquired uterine affections, often requiring hysterectomy, and potentially represents a considerable fraction of the general infertile population. Patients suffering from severe uterine infertility are currently compelled to go through gestational surrogacy or adoption; both approaches, unfortunately, deprive them of the maternal experience of pregnancy and birth. Uterine transplantation represents an outstanding, yet complex, perspective to alleviating definitive uterine infertility. In the past decades, a number of scientific experiments conducted both in animals and women, focusing on uterine transplantation, have led to promising results. Collectively, these findings undoubtedly constitute a sound basis to clinically apply uterine transplantation in the near future. This paper is, however, an overview not only of the extent and limitations of accumulated scientific knowledge on uterine transplantation, but also its ethical implications, in an effort to define the actual place of such an approach among the therapeutic arsenal for alleviating infertility.
© 2011 New York Academy of Sciences
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