236,429 research outputs found
Letter from C. Griffin to George Read
No full textThis photostat is a copy of a letter written and signed by C. Griffin, addressed to his friend, the honorable George Read Esquire. He writes about a celebration by the president of Lexington and the new Constitution. He mentioned plans and his schedule and said that he would be joining Read soon. It is dated Dec. 1788
Letter from C. Griffin to George Read
No full textThis photostat is a copy of a letter written and signed by C. Griffin, addressed to his friend, the honorable George Read Esquire. He writes about a celebration by the president of Lexington and the new Constitution. He mentioned plans and his schedule and said that he would be joining Read soon. It is dated Dec. 1788
Letter to Captain George C. Read
No full textThis document is a letter addressed to Captain George C. Read, commanding the New York freight ship named Constellation. It is dated January 19, 1833. Mond. Morgan writes it, Surveyor of the U. S. Constellation. He writes a plea to send members of his crew to the United States at the next convenient opportunity due to different health concerns. He then lists the names, occupations, and afflictions of each person
Letter to Captain George C. Read
No full textThis document is a letter addressed to Captain George C. Read, commanding the New York freight ship named Constellation. It is dated January 19, 1833. Mond. Morgan writes it, Surveyor of the U. S. Constellation. He writes a plea to send members of his crew to the United States at the next convenient opportunity due to different health concerns. He then lists the names, occupations, and afflictions of each person
Ahuriri plains & harbour, Hawke's Bay [picture] /
No full textInscription on reverse: The harbour is done on a smaller scale than the plains, but they join near where the crosses are put, W.H.R. Read.; Rex Nan Kivell Collection NK202.; Title from inscription c.; Two parts of a panorama.; Exhibited: Alexander Turnbull Library, 1990.; T2846
Neisseria meningitidis and meningococcal disease: recent discoveries and innovations
No full textPURPOSE OF REVIEW: Meningococcal disease is a severe consequence of infection with Neisseria meningitidis, a pathobiont of the pharynx. This organism is panmitic so virulent clones transformed with new genetic material can emerge and cause severe outbreaks. The key to sustainable prevention is to restrict carriage of disease-causing strains and thus reduce the chances of transmission between human hosts.RECENT FINDINGS: Meningococcal population biology has changed recently with emergence of virulent strains linked to a number of sublineages of clonal complex 11. These strains have variously expressed the capsular material of serogroups C and W and caused severe disease in various countries. Glycoconjugate vaccines including quadrivalent (ACWY) and now pentavalent (ACWYX) vaccines are highly immunogenic and prevent disease and carriage due to their respective serogroups. For NmB, new vaccines (4CMenB and MenB-FHbp) containing conserved outer membranes proteins have been deployed and are immunogenic and protective at population level, but clones exist which do not express cognate antigens. In contrast to glycoconjugate vaccines they may not have potent carriage-reducing activity. Mass chemoprophylaxis is gaining credence as an alternative strategy is effective, but has significant shortcomings in sustainability.SUMMARY: Meningococcal disease is well defined genomically for epidemiological purposes. There is potential for unpredictable emergence of clones that may have reduced susceptibility even to modern vaccines, and continued surveillance and vigilance is necessary. However, tremendous strides have been made in recent years.</p
Reading in the mobile era
No full textMobile technology can advance literacy and learning in underserved communities around the world.
Summary
Millions of people do not read for one reason: they do not have access to text. But today mobile phones and cellular networks are transforming a scarce resource into an abundant one.
Drawing on the analysis of over 4,000 surveys collected in seven developing countries and corresponding qualitative interviews, this report paints the most detailed picture to date of who reads books and stories on mobile devices and why.
The findings illuminate, for the first time, the habits, beliefs and profiles of mobile readers. This information points to strategies to expand mobile reading and, by extension, the educational, social and economic benefits associated with increased reading.
Mobile technology can advance literacy and learning in underserved communities around the world. This report shows how
Correlation of group C meningococcal conjugate vaccine response with B- and T-lymphocyte activity.
No full textDespite the success of conjugate vaccination against meningococcal group C (MenC) disease, post-vaccination, some individuals still exhibit rapid waning of initially protective bactericidal antibody levels. The mechanism of this relative loss of humoral protection remains undetermined. In this report we have investigated the relationship between T- and B-cell activation and co-stimulation and the loss of protective antibody titers. We have found that healthy volunteers who lose protective MenC antibody levels one year after receipt of glycoconjugate vaccine exhibit no detectable cellular defect in polyclonal B- or T-cell activation, proliferation or the B-memory pool. This suggests that the processes underlying the more rapid loss of antibody levels are independent of defects in either initial T- or B-cell activation
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