19 research outputs found
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Another injection-free method to effect analgesia when injecting botulinum toxin for palmar hyperhidrosis: Cryoanalgesia [1]
No full textDermatology Online Journal132
Demystifying neurology: Preventing 'neurophobia' among medical students
No full text10.1038/ncpneuro0849Nature Clinical Practice Neurology48462-46
Stop! in the name of love! (before you fail, not pass!)
No full textTeaching and Learning in Medicine192198-19
In-house medical education: Redefining tele-education
No full textTeaching and Learning in Medicine202193-19
Deep brain stimulation in Parkinson’s disease: Looking back, looking forward
No full textPatients with Parkinson’s disease (PD) may present with prodromal (e.g. hyposmia, sleep disorders, constipation), motor (e.g. tremors, rigidity, bradykinesia, postural dysfunction) and non-motor (e.g. cognitive dysfunction, depression) symptoms.1 Treatment is symptomatic, targeting motor and non-motor manifestations, but there is presently no effective disease modifying treatment.1 Although PD therapies have primarily been focused on supplementing dopamine, which has improved survival and quality of life of PD patients,1-3 other neurotransmitter systems (e.g. serotonergic, cholinergic and noradrenergic) are also dysfunctional, especially for the non-motor symptoms.1,4,5 By the time patients reach the later stages of PD, many of them would have developed significant gait and balance difficulties, dysarthria, dysphagia and motor fluctuations like wearing off and levodopa-induced dyskinesias (LID), as well as non-motor symptoms such as orthostasis, depression, dementia and psychosis.1,2,6,
Putting ethics on the spot in neurology
No full text10.1038/ncpneuro1000Nature Clinical Practice Neurology53136-13
An active-architecture approach to COTS integration
No full textCommercial off-the-shelf (COTS) software products are increasingly used as standard components within integrated information systems. This creates challenges since both their developers and source code are not usually available, and the ongoing development of COTS cannot be predicted. The ArchWare Framework approach recognises COTS products as part of the ambient environment of an information system and therefore an important part of development is incorporating COTS as effective system components. This integration of COTS components, and the composition of components, is captured by an active architecture model which changes as the system evolves. Indeed the architecture modelling language used enables it to express the monitoring and evolution of a system. This active architecture model is structured using control system principles. By modelling both integration and evolution it can guide the system’s response to both predicted and emergent changes that arise from the use of COTS products.Peer reviewe
Repurposing povidone-iodine to reduce the risk of SARS-CoV-2 infection and transmission: a narrative review
No full textBACKGROUND: Accumulating data suggest antiviral effects of povidone-iodine against the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. This narrative review aims to examine the antiviral mechanisms of povidone-iodine, efficacy of povidone-iodine against the SARS-CoV-2 virus, and safety of povidone-iodine to human epithelial cells and thyroid function. METHODS: We searched the electronic databases PubMed, Embase, Cochrane Library, ClinicalTrials.gov and World Health Organization’s International Clinical Trials Registry Platform for articles containing the keywords “povidone-iodine”, “SARS-CoV-2” and “COVID-19” from database inception till 3 June 2021. RESULTS: Despite in vitro data supporting the anti-SARS-CoV-2 effects of povidone-iodine, findings from clinical studies revealed differences in treatment response depending on study settings (healthy vs. hospitalized individuals), treatment target (nasal vs. oral vs. pharynx), method of administration (oral rinse vs. gargle vs. throat spray) and choice of samples used to measure study endpoints (nasopharyngeal vs. saliva). One large-scale clinical trial demonstrated reduction in the incidence of SARS-CoV-2 infection among participants who administered povidone-iodine 3 times daily during an active outbreak. Povidone-iodine is also used to disinfect the oro-pharyngeal space prior to dental or otolaryngology procedures. Although existing data suggest minimal impact of povidone-iodine on thyroid function, high-quality safety data are presently lacking. CONCLUSIONS: Povidone-iodine application to the oropharyngeal space could complement existing non-pharmacological interventions to reduce SARS-CoV-2 infection especially in high exposure settings. KEY MESSAGES: Accumulating data suggest antiviral effects of povidone-iodine against the SARS-CoV-2 virus. Findings from clinical studies reveal differences in treatment response depending on study settings, treatment target, method of administration and choice of samples used to measure study endpoints. One large-scale clinical trial observed reduction in the incidence of SARS-CoV-2 infection among participants who administered povidone-iodine 3 times daily during an active outbreak. Povidone-iodine application to the oropharyngeal space could complement existing non-pharmacological interventions to reduce SARS-CoV-2 infection especially in high exposure settings
Characterization and Functional Assessment of Endothelial Progenitor Cells in Ischemic Stroke Patients
No full text10.1007/s12015-020-10064-zSTEM CELL REVIEWS AND REPORTS173952-96
Genes Involved in Oxidative Stress Pathways Are Differentially Expressed in Circulating Mononuclear Cells Derived From Obese Insulin-Resistant and Lean Insulin-Sensitive Individuals Following a Single Mixed-Meal Challenge
No full text10.3389/fendo.2019.00256FRONTIERS IN ENDOCRINOLOGY1
