1,721,002 research outputs found
Fundus autofluorescence in subfoveal choroidal neovascularisation secondary to Pathological Myopia
No full textAIM: To describe the fundus autofluorescence (FAF) characteristics of choroidal neovascularisation (CNV) associated with pathological myopia (PM), and their modification after photodynamic therapy (PDT).DESIGN: Open-label, prospective, interventional case series.METHODS: Forty-two patients affected by subfoveal CNV in PM underwent PDT with a 24-month follow-up. Each patient underwent an ophthalmological examination every 3 months, including FAF and fluorescein angiography. FAF distribution was qualitatively evaluated at the CNV site, around the CNV and outside the area affected by CNV.RESULTS: CNV at baseline showed a high FAF signal with uniform distribution, or with some spots of low FAF internally, in 64% and 36% of cases, respectively. At the 3-month control after PDT, the CNV retained the same response, but a round halo of increased signal extending beyond the site of the PDT application was detectable around the CNV. At the end of the follow-up, a high or a low FAF signal was detected in 40% and 60% of cases, respectively.CONCLUSION: CNV secondary to PM shows a specific, high signal, FAF pattern. A round halo of increased FAF signal surrounding the CNV was detectable after PDT application, whereas a FAF signal progressive reduction was visible at and around the CNV site from the sixth month. A high FAF signal at the CNV site is associated with an improved visual acuity outcome at the 2-year follow-up. Further studies to correlate the morphological and functional features are advisable, especially by means of microperimetric analyses and with a longer-term follow-up
Branch retinal vein occlusion after spontaneous obliteration of retinal arterial macroaneurysm
No full text
Iris indocyanine green videoangiography in diabetic iridopathy
No full textAIMS/BACKGROUND: Iris fluorescein angiography (IFA) is not commonly used in clinical practice, although its value has been demonstrated especially in cases of diabetic disease. IFA is able to show neovascular tufts in order to guide the laser treatment, and it is highly recommended in diabetic patients who need cataract surgery or vitrectomy. Nevertheless, IFA fails to demonstrate the iris vascular pattern in heavily pigmented iris and conspicuous leakage cases. The aim of the study was to evaluate the feasibility of iris indocyanine green videoangiography (IICGV) and to correlate its findings with those of IFA in diabetic iridopathy.METHODS: Thirty six patients affected in varying degrees by diabetic retinopathy underwent an ophthalmic examination including retinal fluorescein angiography, IFA, and IICGV. IICGV was performed using IMAGEnet System H1024.RESULTS: The results demonstrated that IICGV allows precise visualisation of the iris vascular pattern, also in cases of heavily pigmented iris.CONCLUSIONS: Three main findings seemed to be evident: firstly, iris neovascularisations are detected with IFA far more easily than IICGV; secondly, capillary dilatations and iris hypoperfusion are identified far more clearly using IICGV; thirdly, there is no evident relation between capillary dilatation or iris hypoperfusion, and degree of diabetic retinopathy
Subretinal recombinant tissue plasminogen activator and pneumatic displacement for the management of subretinal hemorrhage occurring after anti-VEGF injections for wetAMD.
No full textAbstract: We describe three cases of submacular hemorrhage that occurred two to four days
after anti-VEGF intravitreal injection for occult choroidal neovascularisation in age-related
macular degeneration and their management with 25 gauge pars plana vitrectomy with injection
of subretinal recombinant tissue plasminogen activator (rTPA) followed by fluid-air exchange
and postoperative prone position. Vitrectomy, subretinal rTPA injection and fluid-gas exchange
apply as a safe and effective treatment in these cases. Functional results seem to be positive
especially if surgical treatment is promptly performed
Subthreshold laser treatment for retinal arterial macroaneurysm
No full textPurpose To assess the effects of subthreshold laser treatment (STLT) for retinal arterial macroaneurysms (RAM) associated with foveal exudative manifestations and visual acuity deterioration. Methods Patients with RAM associated with foveal exudative manifestations and best-corrected visual acuity (BCVA) worse than 20/80 Snellen equivalent underwent a ophthalmological examination, including ETDRS visual acuity, optical coherence tomography (OCT) and fluorescein angiography. The patients were prospectively observed for 4 months, and in absence of spontaneous improvement, they underwent STLT using an infrared diode laser. Results Primary outcome measures were a reduction in mean central point thickness (CPT) and BCVA changes at the 12-month examination. Secondary outcomes included changes in mean total macular volume (TMV) and central subfield thickness (CST). Nine patients were enrolled and prospectively followed up. The mean baseline values of BCVA, CPT, TMV and CST were 0.8 +/- 0.1 (logMAR +/- SD), 340 +/- 49 mu m, 7.14 +/- 0.05 mm(3) and 366 +/- 37 mm, respectively. At the 4-month examination following STLT, the mean BCVA improved to 0.6 +/- 0.2, whereas the mean CPT, TMV, and CST decreased to 274 +/- 29 mm, 6.87 +/- 0.11 mm(3) and 296 +/- 33 mu m. At the 12-month examination, the mean BCVA was 0.36 +/- 0.2, the mean CPT was 195 +/- 11 mu m, the mean TMV was 6.55 +/- 0.19 mm(3), and the mean CST was 239 +/- 14 mu m, respectively. No side-effects were noted. In particular, no sign of retinal thinning and underlying backscattering typical of conventional laser treatment could be detected at the site of the laser application on OCT. Conclusion The current pilot investigation of STLT for the treatment of symptomatic RAM revelas encouraging data. A randomised clinical trial is required to ascertain the real efficacy of this technique and the most appropriate settings to be employed
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