11 research outputs found

    Journal of Proteomics & Bioinformatics- Open Access www.omicsonline.com Research Article JPB/Vol.2/August 2009 In Silico Identification of Putative Proton Binding Sites of a Plasma Membrane H +-ATPase Isoform of Arabidopsis Thaliana, AHA1

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    jpb.1000095 Copyright: © 2009 Kumar S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The plasma membrane potential and secondary transport systems in all eukaryotes are energized by the activity of P-type ATPase membrane proteins: H + ATPase (the proton pump) in plants and fungi and Na +, K +- ATPase (the sodium-potassium pump) in animals. The overall shape of proton pumps has been revealed by electron microscopy. The crystal structure of AHA2, a plasma membrane H +-ATPase isoform of Arabidopsis thaliana, by X-ray crystallography at 3.6 Å was available. The isoform is expressed mainly in root. In the present study homology modeling along with transmembrane topology predictions has been used to build the atomic model of AHA1, another plasma membrane H +-ATPase isoform of Arabidopsis thaliana expressing in both root and shoot. AHA2 was used as the template. The homology modeling was done using the MODELLER9v2 software. The model energy was minimized by applying molecular mechanics method. The root mean square deviation (RMSD) for C

    Pattern of Cancer in Nepal from 2003 to 2011

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    Correction: On 15th January 2017, the authors Sunil Kumar Sah and Naval Kishor Yadav were added to the author list.Cancer is global burden of disease in developed and developing countries. It is one of the main causes of death. The environmental factor and life styles are major causes of cancer.This hospital based retrospective study was carried out using data retrieved from the register maintained at seven cancer centers. The most common basis of diagnosis were microscopic (histopathological and cytopathological examination). The diagnosis was also based on clinical examination, radiological examination, endoscopy, biochemical and immunological tests.Most of the cancer cases were diagnosed at BPKMCH (23908) followed by BPKIHS (9668) and BH (5959) and few cases from KCH (518) in 2003 to 2011. The total number of cancer cases were increasing from 2003 to 2011 and it become double in 2011. Out of 75 district of Nepal, more number of cancer cases was found in Kathmandu, Sunsari, Morang, Chitwan, Lalitpur, Jhapa, Kaski, Nawalparasi, Rupendehi and Kavrepalchowk in 2010. Similarly, in 2011 more number of cancer cases was found in Kathmandu, Morang, Jhapa, Sunsari, Chitwan, Lalitpur, Rupendehi, Kaski, Saptari, Bhaktapur. Lung cancer was the common cancer and similarly, other prevalent cancers were cervical, breast, stomach, ovarian and colo-rectum cancer in 2003 to 2011. The common cancers were lung, cervical, breast, stomach, ovarian and colo-rectum. The number of patients is increasing, which may be due to change in life style and lack of education

    Efficient One-pot Synthesis of 4 Hydroxy-2H Chromene by heterogeneously catalyzed ZnO NP and mesoporous aluminosilicate catalysts in solvent free condition.

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    4Hydroxy-2H Chromenes are fused benzopyran rings, an important class of biologically active compounds, widely used as antibacterial, antiviral, antitumor, and anticancer agents. In this present paper, we report the 4 Hydroxy-2H Chromenes synthesis by using two catalysts namely, (i) ZnO nanoparticles and (ii) mesoporous ZnO/AlSBA-15 (7) catalysts. The ZnO NP catalyst was prepared by using leaf extract while ZnO/AlSBA-15(7) catalysts were prepared by the wet chemical route. All catalysts were characterized by XRD, SEM, EDS, FTIR, and N2 sorption techniques. The catalytic activity of the synthesized catalyst was evaluated in the one-pot reaction using aromatic aldehyde and Coumarin, and found to be maximum yield of 81% at temperature 80C, a catalyst dose of 10 mmol %, in time limit of 4h.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author

    Emergence and re-emergence of glanders in India: a description of outbreaks from 2006 to 2011

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    Glanders, a bacterial disease of equines caused by Burkholderia mallei, is a fatal infectious disease of equines and has zoonotic significance. The disease has been eradicated from many countries by statutory testing, elimination of infected animals and import restrictions. However, it is still endemic in parts of Africa, Asia, the Middle East and Central and South America. In India, major glanders outbreaks were reported from different parts of the country between 1976 and 1982. Later, sporadic cases of the disease were reported in 1988, 1990 and 1998. The country remained free of glanders for about eight years until the recent outbreaks occurred in eight States from 2006 to 2007. Recurrent episodes have occurred in Himachal Pradesh and Uttar Pradesh, whereas fresh outbreaks occurred in Chhattisgarh from 2009 to 2010. A total of 164 equines were declared positive; a majority of the positive cases (n = 77) were from Uttar Pradesh, followed by Maharashtra (n = 23), Uttarakhand (n = 21) and Andhra Pradesh (n = 16). Under the provision of Prevention and Control of Infectious and Contagious Disease in Animals Act, 2009, all the infected animals were euthanised and bio-security measures were implemented to curb the further spread of the disease

    Governing globalization in South Asia through a legal praxis of human rights, development and democracy

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    ABSTRACT This doctoral thesis in law seeks to understand, and begin to remedy, the immense and avoidable poverty that disenfranchises at least 30 percent of the world's most populous region. Defining South Asia as Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan and Sri Lanka, the study analyses the multidimensional nature, historical origins and modern dynamics of both this material poverty and poverties of human rights, democracy and development. Both critical analysis and creative response are framed within legal history, human rights jurisprudence, constitutional and administrative law, comparative law and public international law, but the author draws extensively on political economy and history, and partially on philosophy, and cultural studies. Chapter 1 traces the Western evolution of the universal human rights regime, first globalized in 1948 by the Universal Declaration of Human Rights. It also traces South Asian sociopolitical and religious articulations of human dignity and limitations on legitimate power through the ages. Mostly contrary to culturally relativist claims, South Asia's human rights needs are found to be well served by a genuinely universalist regime including justiciable economic, social and cultural rights as inseparable from civil and political. Chapters 2 and 3 survey the historical globalizations that have impacted on South Asia. Although globalization is shown to be a neutral phenomenon, the author identifies the insidious contemporary propagation of a particular neo-liberal ideology as being globalization's inevitable and optimal form. The study analyses this propagation by the International Financial Institutions the World Bank and International Monetary Fund, acting through Structural Adjustment Policies and only partially corrective Poverty Reduction Strategy Papers. Neo-liberalism supposedly unshackles benign market forces from distorting governmental rules to create spontaneous growth that trickles down to the poor; in fact it employs its own rules to privilege the already wealthy, especially Western capital and transnational corporations (TNCs). The thesis urges South Asia to govern globalization pro-actively, seeking the virtuous circle of human rights, plural democracy and equitable development. Positive signs have already included national membership in, and constitutional enshrinement of, universal human rights norms, and certain efforts of civil society and non-governmental organizations, fostered at times by activist judiciaries. Chapter 4 nevertheless catalogues overriding failures to internalize plural democracy and the rule of law, leaving rights nominal and democratic structures hollow. Governments have been obsequious to neo-liberal hegemony, insouciant to their underclasses and exploitative of religious schisms in appeal to tyrannous majoritarianism. The South Asian Association for Regional Co-operation is shown as an inadequate response to the region's multidimensional poverties. Adapting instead the best practices of the Council of Europe, the Organization of American States, the African Union, and the British Commonwealth from Chapter 5, Chapter 6 details a South Asian Union for Human Rights Development and Democracy to replace SAARC. This new regional response complements global human rights norms and offers South Asia solidarity in confronting neo-liberalism, and holding TNCs, IFIs and especially their own governments accountable to the rule of law, equitable development, deep democracy, wide human rights, and larger freedom in peace and security
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