3,709 research outputs found
Self-compression of 4.9 µm pulses to sub-40 fs with 2 mJ energy in Zinc Sulfide
No full textNonlinear self-compression of few-cycle multi-mJ pulses at 4.9 µm in ZnS is presented. 80 fs input pulses are compressed to 37 fs with 2.1 mJ energy at a 1 kHz repetition rate. © 2024 The Author(s
Correction to: Chamoun et al., Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection
No full textChamoun MN, Blumenthal A, Sullivan MJ, Schembri MA, Ulett GC. 2018. Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology. https://doi.org/10.1080/1040841X.2018.1426556.
When the above article was first published online, the below three corrections were missed.
The author ‘Antje Blumenthal’ was wrongly affiliated to the affiliation “cSchool of Chemistry and Molecular Biosciences, and Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Australia”. Now this affiliation has been removed for this author.
The affiliation ‘bTranslational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia’ of the author ‘Antje Blumenthal’ should read ‘bThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia’.
In Table 3, the sentence ‘Benefit of manipulating IL-17 levels to improve immunization strategies M. tuberculosis’ should read “Benefit of manipulating IL-17 levels to improve immunization strategies against M. tuberculosis”.No Full Tex
Generation of 22-mJ, 2.0-ps Pulses from a 1-kHz Ho:YLF Regenerative Chirped Pulse Amplifier
No full textWe report a CW-pumped Ho:YLF regenerative amplifier (RA) delivering pulses with 22.5-mJ energy and 2.0-ps duration at 1 kHz. The RA emitting at 2051 nm is broadband-seeded and implemented in a chirped pulse amplification system. © 2024 The Author(s
Pure-rotational 1D-CARS spatiotemporal thermometry with a single regenerative amplifier system
No full textWe report spatiotemporal pure-rotational coherent anti-Stokes Raman spectroscopy (CARS) in a one-dimensional imaging arrangement obtained with a single ultrafast regenerative amplifier system. The femtosecond pump/Stokes photon pairs, used for impulsive excitation, are delivered by an external compressor operating on a ∼35% beam split of the uncompressed amplifier output (2.5 mJ/pulse). The picosecond 1.2 mJ probe pulse is produced via the second-harmonic bandwidth compression (SHBC) of the ∼65% remainder of the amplifier output (4.5 mJ/pulse), which originates from the internal compressor. The two pump/Stokes and probe pulses are spatially, temporally, and repetition-wise correlated at the measurement, and the signal generation plane is relayed by a wide-field coherent imaging spectrometer onto the detector plane, which is refreshed at the same repetition rate as the ultrafast regenerative amplifier system. We demonstrate 1 kHz cinematographic 1D-CARS gas-phase thermometry across an unstable premixed methane/air flame-front, achieved with a single-shot precision <1% and accuracy <3%, 1.4 mm field of view, and an excellent <20 µm line-spread function.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Flight Performance and Propulsio
Project: Establishing an accounting outsourcing company "MJ Grāmatvedība" Ltd
No full textProjekta ideja ir izveidot grāmatvedības ārpakalpojumu uzņēmumu SIA „MJ Grāmatvedība”, kurš sniegtu pilna vai daļēja cikla grāmatvedības pakalpojumus, sākot ar pirmreizējo dokumentu apstrādi un beidzot ar visu nepieciešamo atskaišu sagatavošanu, kā arī konsultāciju sniegšanu. Projekta mērķis ir ne tikai sniegt grāmatvedības pakalpojumus, bet arī analizēt uzņēmumu darbību un izstrādāt ieteikumus darbības uzlabošanai. Darba autore uzskata, ka nozares pārstāvjiem ir būtiski jāpierāda sava nozīme un to kādam jābūt mūsdienu grāmatvedim. Grāmatvedis nav tikai persona, kura izdara konkrētus darbus, nodos atskaites, tas ir cilvēks, kuram labi jāpārzina nodokļu sistēma, finanšu vadīšana, jāspēj sniegt padomus uzņēmuma finanšu vadības uzlabošanai, kā arī jāspēj pielāgoties tehnoloģiju radītajām izmaiņām. Maģistra darbs apjoms ir uz 105 lappusēm, kas sastāv no 7 nodaļām, 17 pielikumiem, 22 tabulām un 7 attēliem. Darba izstrādē izmantoti 70 informācijas avoti.The general project idea is to establish the accountancy firm MJ Accountancy Ltd., which would provide full or half-cycle accountancy services including the processing of primary documentation, reports’ preparation, and providing of the accountancy consultations. The aim of the project is not only to provide accountancy consultations but also to deal with firms activity analysis and developing suggestions on their activity improvement. The author of the project supports the idea that the field representatives must constantly sustain the status of the accountant’s profession in current times. The accountant is not only the person who executes one’s regular duties and submits reports, but also the person who is competent in the field of taxes, financial management, able to advise on improvements in financial management, and above all able to adapt to the technological changes. The volume of the project is 105 pages, which includes 7 chapters, 17 appendices, 22 tables, 7 figures. 70 sources of information were used in master’s thesis
Design, development and optimisation of veterinary intravaginal controlled release drug delivery systems
No full textThis Thesis begins by discussing the application of controlled drug delivery to the intravaginal delivery of hormones to control the oestrous cycle of farmed animals, with particular emphasis on the delivery of progestagens to cattle and sheep. The introduction highlights the recent advances made by animal physiologists in their knowledge of the oestrous cycle in cattle and sheep and how these advances have impacted upon the manner in which currently available intravaginal controlled release products are used. In addition it discusses the advances pharmaceutical scientists have made in response to the new knowledge.
The CIDR®1900 Cattle insert is a commercially available silicone based intravaginal delivery system containing the natural steroid progesterone for fertility regulation in cattle. It was designed in 1987 to be inserted for 12 days. Advances made in oestrous cycle understanding by animal scientists have resulted in this product being inserted for much shorter treatment periods of 7 days. Rathbone et al. recently optimised the CIDR®1900 Cattle insert for seven day insertion periods. The outcome of these scientists work was a manufactured prototype which, when compared to the CIDR®1900 Cattle insert, contained a reduced initial drug load and a much lower residual drug load after use. For commercial production the prototype insert needed to be scaled up. This process required detailed pharmaceutical characterisation, invitro release assessment, invivo bioequivalency and chemical and physical stability studies to be performed on the scaled up product (CIDR®1380 Cattle insert) to ensure the success of the scale up process. This characterisation process forms Chapters Two and Three of this Thesis.
Knowledge of the mechanism of release of a drug from a pharmaceutical product provides the formulation scientist with the necessary insight to optimise, further develop or recognise the potential and limitations of a product. Chapter Four explores the mechanism of release of progesterone from the silicone based CIDR® Cattle insert both invitro and invivo. Cumulative release data from both invitro and invivo studies were fitted against conventional mathematical models to determine the mechanism of release of progesterone from the CIDR® Cattle insert. In addition, an experimental method was developed to assess the validity of the models. The method involved taking thin consecutive horizontal slices from the surface of CIDR® Cattle inserts after various periods of release. Cumulative release of progesterone, both invitro and invivo, was linear when plotted against the square root of time, suggesting that release from the CIDR® Cattle insert occurred in accordance with the square root of time mechanism. However, experimental evidence from the horizontal slicing technique only supported the curve fitting evidence for invitro release. When the insert was investigated invivo, the slicing method indicated that a novel release mechanism was in operation which was better described by a zero order process.
Chapters Five and Six of this Thesis direct their focus to oestrus control in sheep. Chapter Five utilises information gained from both Rathbone et al. and the work performed in this Thesis on the CIDR® Cattle insert to characterise and optimise the commercially available sheep equivalent of the CIDR ® 1900 Cattle insert (known as the CIDR® Sheep and Goat insert). The Chapter successfully characterises the CIDR® Sheep and Goat insert, defines the parameters of, and tests, an optimised version of this sheep product.
The final Chapter of this Thesis investigates the use of poly-(ε-caprolactone) as a platform for the intravaginal delivery of progesterone to control oestrus in sheep. Silicone has certain limitations as a drug delivery platform, and with animal physiologists recent advances in knowledge, pharmaceutical scientists will need more versatile delivery platforms to develop intravaginal drug delivery systems which fulfil the future demands of the animal scientists
Initial state and transition-state solvation effects in the cobaltotungstate oxidation of iodide in binary aqueous solvent mixtures
No full textPT: J; CR: AMJAD Z, 1977, CAN J CHEM, V55, P3581 BAKER LCW, 1956, J AM CHEM SOC, V78, P4503 BECK MT, 1968, COORDIN CHEM REV, V3, P91 BLANDAMER MJ, UNPUB CAN J CHEM BLANDAMER MJ, 1978, J CHEM SOC CHEM COMM, P963 BLANDAMER MJ, 1979, PURE APPL CHEM, V51, P2087 BLANDAMER MJ, 1980, COORDIN CHEM REV, V31, P93 BLANDAMER MJ, 1980, J CHEM SOC DA, P1 BLANDAMER MJ, 1980, J CHEM SOC DA, P2442 BRODOVITCH JC, UNPUB BURGESS J, 1968, J CHEM SOC A, P2571 BURGESS J, 1970, J CHEM SOC A, P2111 BURGESS J, 1970, J CHEM SOC A, P2351 BURGESS J, 1972, INORGANIC REACTION M, V2, P127 BURGESS J, 1973, J CHEM SOC A, P825 BURGESS J, 1974, INORGANIC REACTION M, V3, P142 BURGESS J, 1977, INORGANIC REACTION M, V5, P158 BURGESS J, 1979, INORGANIC REACTION M, V6, P168 COX BG, 1974, ANN REP CHEM SOC A, V71, P249 COX BG, 1979, J CHEM SOC F1, V75, P1780 COX BG, 1979, J CHEM SOC FARAD T 1, V75, P86 DELIGNY CL, 1965, RECL TRAV CHIM PAY B, V84, P81 ELLIS KJ, 1973, J CHEM SOC DA, P1533 GRUNWALD E, 1948, J AM CHEM SOC, V70, P846 KANEMAQUIRE LAP, 1975, J CHEM SOC DA, P1890 KEPERT DL, 1978, J CHEM SOC DA, P137 MARCUS RA, 1968, J PHYS CHEM-US, V72, P891 PELIZZETTI E, 1976, INORG CHEM, V15, P2898 SUBHANI MS, 1978, REV ROUMAINE CHIM, V23, P719 UDOVENKO VV, 1977, RUSS J INORG CHEM, V22, P168 WELLS CF, 1973, J CHEM SOC FARAD T 1, V69, P984 WELLS PR, 1968, LINEAR FREE ENERGY R, CH4; NR: 32; TC: 14; J9: TRANSIT METAL CHEM; PG: 4; GA: NG073Source type: Electronic(1
An extension of the weighted sum of gray gases non-gray gas radiation model to a two phase mixture of non-gray gas with particles
No full textA great deal of efforts has been exercised to date to accurately model the non-gray behavior of the gases. Among others, the weighted sum of gray gases model (WSGGM), which replaces the non-gray gas behavior by an equivalent finite number of gray gases, is a simplified model yielding reasonable results. However, a discussion on the weighting factors required for an estimation of radiation in a mixture of non-gray gas/gray particulate is not yet established for WSGGM, since they are dependent on the particle number density, particle size distribution: local temperature and partial pressure. Consequently, the relation between the weighting factors used in the WSGGM for a mixture of non-gray gas and gray particles with scattering in the thermal non-equilibrium has been discussed here, which has not been done before to the author's best knowledge. Weighting factors for the particles, of which temperature is different from that of the gas, were evaluated analytically for the WSGGM. The results were, then, validated for the problem of isothermal gas containing soot particulates between two parallel slab walls. For further application, the approach derived here was implemented to examine the non-gray radiative effects of the two phase mixture in an axisymmetric cylinder by changing such various parameters as the particle temperature, non-gray gas composition and particle concentration. The effects of thermal non-equilibrium in a mixture of gas and particles were also discussed in parallel with scattering effects by particles. Parametric study showed that a variation in the gas concentration yielded a noticeable change in the radiative heat transfer when the suspended particle temperature was different from the gas temperature. New contribution of this study consisted in an extension of applicability of the WSGGM non-gray model to two phase radiation. (C) 2000 Elsevier Science Ltd. All rights reserved.The authors wish to acknowledge the financial support of the Korea Research Foundation made in the program year of 1998 under the contract 1998-018-E00016
A giant pancreatic pseudocyst in a patient with HIV infection.
No full textThis article describes the first case of a giant pancreatic pseudocyst in a 48-year-old man with HIV infection under combination antiretroviral therapy. The patient presented with an abdominal mass involving the epigastrium, left hypochondrium, and left flank. An enhanced abdominal computed tomography (CT) scan showed a well-defined cyst of 21 cm in diameter, with a liquid content that dislocated adjacent viscera. Microbiological and cytological tests on fluid were negative, confirming diagnosis of pancreatic pseudocyst. The CT-guided percutaneous drainage was carried out and the patient's clinical condition gradually improved. © The Author(s) 2012
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