11,390 research outputs found
CHronic use of Amiodarone aGAinSt Implantable cardioverter-defibrillator therapy for primary prevention of death in patients with Chagas cardiomyopathy Study: Rationale and design of a randomized clinical trial
No full textBackground the implantable cardioverter defibrillator (ICD) is better than antiarrhythmic drug therapy for the primary and secondary prevention of all-cause mortality and sudden cardiac death in patients with either coronary artery disease or idiopathic dilated cardiomyopathy. This study aims to assess whether the ICD also has this effect for primary prevention in chronic Chagas cardiomyopathy (CCC).Methods in this randomized (concealed allocation) open-label trial, we aim to enroll up to 1,100 patients with CCC, a Rassi risk score for death prediction of >= 10 points, and at least 1 episode of nonsustained ventricular tachycardia on a 24-hour Holter monitoring. Patients from 28 centers in Brazil will be randomly assigned in a 1: 1 ratio to receive an ICD or amiodarone (600 mg/d for 10 days, then 200-400 mg/d until the end of the study). the randomization sequence will be generated by computer, and the members of the committees responsible for end point validation and data analysis will be blinded to study assignment. the primary end point is all-cause death, and enrolment will continue until 256 patients have reached this end point. Key secondary end points include cardiovascular death, sudden cardiac death, hospitalization for heart failure, and quality of life. We expect follow-up to last 3 to 6 years, and data analysis will be done on an intention-to-treat basis. This trial is registered with ClinicalTrials.gov number NCT01722942.Conclusion CHAGASICS is the first large-scale trial to assess the benefit of ICD therapy for the primary prevention of death in patients with CCC and nonsustained ventricular tachycardia, who have a moderate to high risk of death.Univ São Paulo, Pacemaker Clin, Inst Coracao InCor, São Paulo, BrazilAnis Rassi Hosp, Div Cardiol, Goiania, Go, BrazilUniv São Paulo, Div Cardiol, Fac Med Ribeirao Preto, São Paulo, BrazilEscola Paulista Med UNIFESP, Div Cardiol, São Paulo, BrazilRes Inst HCor Hosp Coracao, São Paulo, BrazilUniv São Paulo, Arrhythmia Clin, Inst Coracao InCor, São Paulo, BrazilUniv São Paulo, Inst Coracao InCor, São Paulo, BrazilEscola Paulista Med UNIFESP, Div Cardiol, São Paulo, BrazilWeb of ScienceSt Jud
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Emmett L. Bennett, Jr. Offprint Collection
No full textThe scholarly library of Emmett L. Bennett, Jr. compiled in the course of his Editorship of the journal Nestor (founded in 1957). The collection includes scholarly publications (offprints) and manuscripts sent by prospective authors to Dr. Bennett. Includes a Finding Aid (PDF and Word) and Catalog (an Excel document for each of two record groups: offprints collected up to 1995, and offprints collected from 1995-2011). Both the Finding Aid and Catalog are provided to facilitate researchers' searches for offprints by author, title, journal, year, and subject.Classic
Otimização do tratamento medicamentoso na doença arterial coronariana: tarefa para o subespecialista?
No full textLetter from T.H. Hayes, Jr. to Attorney Henry M. Beaty Jr
No full textA letter of recommendation for Russell B. Sugarmon, Jr. to be admitted to the bar in Memphis and Shelby County. The author commends his ability, character, and family background
Análise econômica dos Stents coronarianos farmacológicos no Brasil: para todos ou para poucos pacientes? Economic analysis of drug-eluting coronary stents in Brazil: a choice for all or just for a few patients?
No full textAyaanella M.T. Khan & Anis 2017, gen. nov.
No full textAyaanella M.T. Khan & Anis gen. nov. (Figs 1–10) Type species. Ayaanella globugaster M.T. Khan & Anis sp. nov. Description. Female. Head (Fig. 1); antennal torulus placed slightly above lower margin of eye; malar space dark, as long as or shorter than eye width; ocelli arranged in obtuse triangle; mandible (Fig. 2) 4-dentate, third tooth shorter, and a concavity between third and fourth teeth; maxillary palp (Fig. 3) unsegmented, swollen basally, with one seta at apex. Antennal formula 1, 1, (2), 2, 3; antenna (Figs 5–8) with 2 anelli (Figs 7, 8: A1 and A2); funicle 2 segmented, segments asymmetrical, with PLS, F2 broader than long; clava 3-segmented with very long setae and PLS. Mesosoma with pronotum medially divided into two plates; mid lobe of mesoscutum and scutellum each with 2 pairs (2+2) setae; side lobe of mesoscutum with 1 seta along anterolateral corner and axilla; propodeal margin almost straight posteriorly and about as long as metanotum medially; posterior two-thirds of mesoscutum, and scutellum with longitudinally cellulate sculpture, anterior one-third of mesoscutum with polygonal cells. Fore wing hyaline with venation extending to slightly less than half wing length; costal cell very narrow; marginal vein longer than premarginal or stigmal veins; premarginal vein broader than marginal vein; RS1 absent [except two or three setae below stigmal vein]; disc moderately densely setose with setae arranged in rows. Legs with tarsal formula 3-3-3. Metasoma longer than mesosoma; ovipositor short, extending from TV of gaster and hardly exserted. Male. Unknown. Etymology. The genus is named after the son of the second author (SBA), Ayaan + ‘-ella’ Latin suffix added to generic name.Published as part of Khan, Mohd Talib & Anis, Shoeba Binte, 2017, A new genus of Trichogrammatidae (Hymenoptera: Chalcidoidea) from India, pp. 165-168 in Zootaxa 4344 (1) on pages 165-166, DOI: 10.11646/zootaxa.4344.1.9, http://zenodo.org/record/104236
DIRETRIZ DA SOCIEDADE BRASILEIRA DE CARDIOLOGIA E DA SOCIEDADE BRASILEIRA DE HEMODINÂMICA E CARDIOLOGIA INTERVENCIONISTA SOBRE INTERVENÇÃO CORONÁRIA PERCUTÂNEA
No full textInst Dante Pazzanese Cardiol, Sao Paulo, SP, BrazilUniv Sao Paulo, Fac Med, Hosp Clin, Ribeirao Preto, SP, BrazilHosp Coracao Anis Rassi, Goiania, Go, BrazilInst Coracao Triangulo, Uberlandia, MG, BrazilEscola Paulista Med, Sao Paulo, SP, BrazilHosp Felicio Rocho, Belo Horizonte, MG, BrazilReal & Benemerita Soc Portuguesa Beneficencia, Sao Paulo, SP, BrazilUniv Sao Paulo, Fac Med, Inst Coracao, Hosp Clin, Sao Paulo, SP, BrazilFundacao Univ Cardiol, Inst Cardiol Rio Grande do Sul, Porto Alegre, RS, BrazilHosp Santa Paula, Cardioctr, Joao Pessoa, Paraiba, BrazilHosp Bandeirantes, Sao Paulo, SP, BrazilClin Sao Vicente, Rio De Janeiro, RJ, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, BrazilWeb of Scienc
Chagas heart disease: pathophysiologic mechanisms, prognostic factors and risk stratification
No full textChagas heart disease (CHD) results from infection with the protozoan parasite Trypanosoma cruzi and is the leading cause of infectious myocarditis worldwide. It poses a substantial public health burden due to high morbidity and mortality. CHD is also the most serious and frequent manifestation of chronic Chagas disease and appears in 20-40% of infected individuals between 10-30 years after the original acute infection. In recent decades, numerous clinical and experimental investigations have shown that a low-grade but incessant parasitism, along with an accompanying immunological response [either parasite-driven (most likely) or autoimmune-mediated], plays an important role in producing myocardial damage in CHD. At the same time, primary neuronal damage and microvascular dysfunction have been described as ancillary pathogenic mechanisms. Conduction system disturbances, atrial and ventricular arrhythmias, congestive heart failure, systemic and pulmonary thromboembolism and sudden cardiac death are the most common clinical manifestations of chronic Chagas cardiomyopathy. Management of CHD aims to relieve symptoms, identify markers of unfavourable prognosis and treat those individuals at increased risk of disease progression or death. This article reviews the pathophysiology of myocardial damage, discusses the value of current risk stratification models and proposes an algorithm to guide mortality risk assessment and therapeutic decision-making in patients with CHD
A One-Way Car-Sharing Based Approach for Combined Shared Mobility of Freight and Passengers
No full textClimate change stresses the need for research and development of innovative sustainable mobility solutions that provide reliable and convenient door-to-door services for both passengers and freight. The increase in urban population and the popularity of e-commerce further highlights the need for action. In this regard, crowd-shipping is often perceived as an efficient, cost-effective, and sustainable alternative (or complement) to the management of urban freight mobility through efficient utilization of current transportation capacities. In this framework, inspired by the concept of MaaS (Mobility as a Service) in integrating various forms of transport and transport-related services into a single on-demand mobility service, this paper proposes a car-sharing-based service for the combined mobility of passengers and freight. In doing so, one-way car-sharing and crowd-shipping concepts are integrated in order to serve part of the existing freight demand in a sustainable and cost-efficient way for users, societies, and the environment. An optimization model is proposed to optimally plan the activation of one-way car-sharing and crowd-shipping services and to determine the optimal number of vehicles to assign to them. Such decisions are aimed at minimizing the total imbalance by serving passenger and freight demand during different time periods. In doing so, the willingness of users to carry freight in their vehicles is also taken into consideration. The capability of the proposed approach is evaluated through representative numerical examples aimed at showing the impact of the model parameters on the solution.Transport and Plannin
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