5 research outputs found
Glioblastoma Multiforme: Five-year Experience at a Tertiary Cancer Centre in North India
No full textBackground: Glioblastoma Multiforme (GBM) is one of the most common brain tumors. Despite multimodal treatment with surgery and chemoradiotherapy, survival outcome remains bleak. Many patients do not tolerate and complete such aggressive treatment. Our Center is the largest tertiary care referral hospital in the region; we report our findings about 5-year outcome in these patients.
Methods: From January 2014 to December 2018, we conducted a retrospective observational study. We included patients with histopathologically proven diagnosis of GBM. Descriptive statistics of patient data was retrieved from patient files at Hospital Based Cancer Registry (HBCR) at our State Cancer Institute (SCI). All the data was recorded and analyzed using appropriate statistical methods.
Results: 54 histopathologically proven cases of GBM were enrolled. Most patients were in the fifth and sixth decade of life, with a male to female ratio of 2:1. Headache was the most common presenting symptom in 23 (42.5%) patients followed by seizures in 13 (24%) patients. The average lesion size was 4.7 cm. Gross total excision was done in 12 (22%) patients, near total excision in 8 (15%) patients. 48 (89%) patients received radiation therapy concurrent with temozolomide. 4 (7.4%) patients had complete response with chemoradiotherapy. Median survival was 16 months. Patients who underwent Gross total excision or near total excision had a median survival of 15.9±3.56 months, whereas patients who underwent subtotal excision had a median survival of 8.29±4.14 months. Patients who completed trimodality therapy had better survival.
Conclusion: Patients receiving trimodality therapy with gross total excision and adjuvant chemoradiation achieve best survival rates. Advanced age, poor performance score, larger tumor size, deep seated lesions, suboptimal tumor excision, and steroid dependency carry poor prognosis
Practice of SCM Performance Drivers and Procurement Process: Case Study on Globe Pharmaceuticals Limited
Full text linkThis paper presents a descriptive research which addresses a case study on Globe Pharmaceuticals Limited., Bangladesh. The main objective of this study is to identify and demonstrate the practices of Supply Chain Management (SCM) upon the organization. The study is conducted by in-depth interviewing of the personnel working in the commercial department of the organization as well as secondary data. Globe Pharmaceuticals Limited has been manufacturing medicines since 1986 with a view to provide high quality medicines throughout the country. They are not only distributing medicines in the country but also exporting to international market. Till now, they have expanded their overseas marketing coverage in Singapore, Vietnam, Philippines, Srilanka, Myanmar, Yemen and Cambodia. The company is now in the process of receiving regulatory approvals for start its business in various countries of Africa, Middle East and Latin America. This has been possible by effective implementation of supply chain management performance drivers. The author has thoroughly analyzed SCM performance drivers and procurement process of Globe Pharmaceuticals Limited, to explore innovative ideas regarding SCM practices in pharmaceuticals industry. The performance of the supply chain of Globe Pharmaceuticals Limited is evaluated based upon the six supply chain performance drivers; Facilities, Inventory, Transportation, Information, Sourcing, Pricing. These drivers are utilized to create the balance between responsiveness and efficiency. The right combination of efficiency and responsiveness increases the performance of the supply chain and reduce inventory and operating expense simultaneously. Globe Pharmaceuticals Limited, practices all the six drivers of supply chain performance and tries constantly to improve its performance. There are certain aspects of their supply chain where they can bring improvements which will improve the performance of the whole supply chain. Keywords: Supply chain management, Practice, Performance drivers, Procurement process, Globe Pharmaceuticals Limite
Author Correction: B-cell-specific checkpoint molecules that regulate anti-tumour immunity.
No full textA cryptographic technique applying Laplace Transform and Exponetial Function
Full text linkSecured Information transformation from one person to another is very much essential in this world of internet. In electronic communications such as system security, smart card, mobile communications etc, the data are stored in the various applications used in them. While using all the applications, we give permission to access all the information. Cryptography is based on transformation of multiple rounds of transformation of messages in the form of plain text as input into encrypted text message. Through suitable mathematical technique, secrecy of the information is maintained. This paper proposes a Laplace and its inverse transform technique with a suitable function for encryption and decryption of a message
