322,918 research outputs found

    Dati paleogeografici a supporto di un Gis geo-archeologico

    No full text
    During the archaeological campaign in “Campo della Fiera” (Orvieto - Umbria) it was discover an important archaeological situ, that whose frequentation turns is many extended since Etruschi (VI sec. a.C.- XIV sec. d.C.). The paleogeographic evolution map of this area based on the geologic, geomorfologic and fotogeologic study of the place confirm this archaeological hypothesis . The paleogeographic evolution of the area among “mesa” of Orvieto and Alfina plateau, appears correct with aspects of the place about the historical-archaeological development and about the natural mechanisms that was the cause of actual configuration of the place. It was also obtained a geo-archaeological GIS, with data base geological/geomorphological and archaeological data too

    Different levels of variability in subtypes 1b and 4a of hepatitis C viruses

    No full text
    We performed genetic and phenic analyses to evaluate nucleotide and amino-acid sequences of the amino-terminus of the E1 protein of HCV genotype 1b (extracted from databank) and 4a (characterised in this study). The non-synonymous (ka) mutation analysis demonstrated that the genome of genotype 1b was not saturated by variations, with a rate of transition/transversion (s/v) of 1.5, which is similar to the expected ratio (i.e., 2.0). The s/v ratio in genotype 4a isolates was lower (0.98), indicating saturation due long-term variability. Moreover, the genotype 1b sequences showed a higher number of ka mutations (s+v) (mean of 2.8 per sequence) than genotype 4a (mean of 1.5). The introduction of ka mutations resulted in a higher degree of amino acid variability in genotype 4a. In the genome of genotype 1b, each nucleotide mutation introduced new amino acids, with a Granthan distance of 3.35-42.5, whereas for genotype 4a the distances ranged from 48.8 to 102.1. The phenic analysis also indicated different and complex patterns of amino-acid substitution. Finally, diverse isoelectric points and hydrophobicity were predicted for the two genotypes, with a higher acidity for genotype 4a E1 proteins
    corecore