196,565 research outputs found
Editoria italiana per l'insegnamento delle lingue straniere: storia e geografia. Bibliografia
No full textSi tratta della bibliografia ragionata dell'editoria scolastica in ambito linguistico. E' il risultato di un lungo spoglio di biblioteche, repertori r a rchivi che ha permesso di valutare e catalogare i numerosi volumi che nell'ultimo ventennio sono stati pubblicati sull'argomento. Comprende una prima parte dedicata agli studi di carattere generale, seguita da due sezioni organizzata la prima diacronicamente e la seconda per aree geografiche
Best Oral Presentation Award
No full textIl paper “A Novel Surgical Robotic Platform Minimizing Access Trauma” di T. Ranzani, C. Di Natali, M. Simi, A. Menciassi, P. Dario, P. Valdastri presentato al 4th Hamlyn Symposium on Medical Robotics 19-20 June, 2011 the Royal Society, London, UK, è stato premiato con il “Best Oral Presentation” Award
C. Biondi, B. O. Ranzani, C. Rosso, M. G. Salvatores, Intorno a Montesquieu, ed. C. Rosso, 1970
No full textVercruysse Jérôme. C. Biondi, B. O. Ranzani, C. Rosso, M. G. Salvatores, Intorno a Montesquieu, ed. C. Rosso, 1970. In: Dix-huitième Siècle, n°4, 1972. pp. 439-440
L’inclusione dei minori stranieri non accompagnati nei contesti sanitari: uno studio di caso
No full textNelle ultime decadi si è assistito a un progressivo intensificarsi della complessità dei servizi educativi e di cura, sempre più caratterizzati da un elevata eterogeneità socioculturale e linguistica (Zoletto, 2012). Nei contesti sanitari, tale eterogeneità si traduce in sfide inedite per l’esercizio quotidiano della professione medica. Di particolare urgenza è il tema dell’inclusione di pazienti con poche o nulle competenze linguistiche nella lingua in cui si svolge l’incontro medico. Come garantire uno scambio efficace di informazioni? Come attuare processi di shared-decision making nell’ottica del rispetto dell’autonomia e autodeterminazione del paziente? La posta in gioco si complica ulteriormente quando i pazienti sono minori stranieri non accompagnati (MSNA). Nonostante questa etichetta notoriamente racchiuda una pluralità di situazioni disparate tra loro (soprattutto in termini di provenienza), i MSNA hanno in comune il fatto di aver intrapreso un percorso migratorio da minorenni e di trovarsi nel paese di accoglienza senza un adulto legalmente responsabile di riferimento (Agostinetto, 2018; Salinaro, 2020). Data la vulnerabilità sociale dei MSNA inasprita dal divario linguistico, i professionisti della cura sono chiamati a confrontarsi con le caratteristiche e i bisogni specifici di questi pazienti. Come includere i MSNA nel corso della visita medica? Come garantire la promozione di agency e autonomia del paziente? Nel tentativo di offrire possibili risposte e spunti di riflessione intorno a questi interrogativi, il presente contributo riporta alcuni risultati di uno studio di caso condotto nell’ambito di visite mediche di base di MSNA (Caronia et al., 2020, 2022)
C. Biondi, B. O. Ranzani, C. Rosso, M. G. Salvatores, Intorno a Montesquieu, ed. C. Rosso, 1970
No full textVercruysse Jérôme. C. Biondi, B. O. Ranzani, C. Rosso, M. G. Salvatores, Intorno a Montesquieu, ed. C. Rosso, 1970. In: Dix-huitième Siècle, n°4, 1972. pp. 439-440
The pediatrician’s normalizing practice in well-child visits : translating statistic measures into lay terms as a means to reassure parents
No full textDrawing on a corpus of 23 video-recorded well-child visits and adopting a
conversation analysis-informed approach, this chapter illustrates how
pediatricians accomplish a no-problem assessment of infants’ physical
growth by implementing a “normalizing practice”. It consists of
pediatricians a) formulating the numerical values for length, weight, and
head circumference in terms of statistical normality which is “talked into
being” by referring to the relevant growth percentile, and b) in the
subsequent translation of the statistically-formatted assessment into lay
language. The analysis highlights the pragmatic and epistemic work of the
normalizing practice: reassuring parents and ratifying medical knowledge
as the most authoritative voice. I argue that pediatricians and parents
construct a shared understanding of unproblematic infant growth by
cooperatively constituting statistics as the ultimate trustworthy
representation of “normality”
Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?
No full textElisa Mura,1 Stefano Govoni,1 Marco Racchi,1 Valeria Carossa,1 Guglielmina Nadia Ranzani,2 Massimo Allegri,3,4 Ron HN van Schaik5 1Department of Drug Sciences, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy; 2Department of Biology and Biotechnology, University of Pavia, Pavia, Italy; 3Pain Therapy Service, Foundation IRCCS San Matteo Hospital, Pavia, Italy; 4Department of Clinical, Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; 5Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands Abstract: The 118A>G single nucleotide polymorphism (SNP) in the µ-opioid receptor (OPRM1) gene has been the most described variant in pharmacogenetic studies regarding opioid drugs. Despite evidence for an altered biological function encoded by this variant, this knowledge is not yet utilized clinically. The aim of the present review was to collect and discuss the available information on the 118A>G SNP in the OPRM1 gene, at the molecular level and in its clinical manifestations. In vitro biochemical and molecular assays have shown that the variant receptor has higher binding affinity for ß-endorphins, that it has altered signal transduction cascade, and that it has a lower expression compared with wild-type OPRM1. Studies using animal models for 118A>G have revealed a double effect of the variant receptor, with an apparent gain of function with respect to the response to endogenous opioids but a loss of function with exogenous administered opioid drugs. Although patients with this variant have shown a lower pain threshold and a higher drug consumption in order to achieve the analgesic effect, clinical experiences have demonstrated that patients carrying the variant allele are not affected by the increased opioid consumption in terms of side effects. Keywords: µ-opioid receptor, opioids, pharmacogenetics, pain, analgesi
Pain and the pharmacogenetics at the fuzzy border between pain physiopathology and pain treatment
No full textNociceptive pain is time limited and severe nociceptive pain normally responds well to treatment with opioids, On the contrary, neuropatic pain is frequently chronic, and tends to have a less robust response to treatment with opioids. The unsolved problem of insufficient pain treatment at clinical level, including both wanted analgesic effects and unwanted side effects, is a stimulus to expand the knowledge on the physiophatology of pain and on the involved molecular mechanisms. In particular, it is important not only to better understand the molecular mechanisms associated to drugs effects but also to characterize the genetic traits underlying pharmacokinetic (PK) and pharmacodynamic (PD) mechanisms related to drugs. Literature analysis reveals that there are interesting genetic polymorphisms that are associated either to the sensitivity to pain and to PD response to drugs, or to the metabolic and excretion pathways. Pharmacogenetics/pharmacogenomics holds the promise that drugs might in the next future be tailor-made for individuals and adapted to each person's own genetic background. Collected information, allowing to design combined therapies and to dissect analgesic from addictive properties of opioids within a given patient, will also contribute to contrast the persisting opiophobia in medical practice
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