3,745 research outputs found
Effects of Moritella viscosa antigens on pro-inflammatory gene expression in an Atlantic salmon (Salmo salar Linnaeus) cell line (SHK-1)
No full textMoritella viscosa is the causative agent of winter ulcer disease in salmonids reared in North-Atlantic countries. In this study the effects of selected M. viscosa antigens on cytotoxicity and pro-inflammatory gene expression in an Atlantic salmon (Salmo salar Linnaeus) macrophage-like cell line (SHK-1) were examined. SHK-1 cells were stimulated with live and heat-killed bacterial cells, extracellular products (ECP) and an extracellular vibriolysin, termed MvP1. Following incubation, cytotoxicity and expression levels of interleukin-1β (IL-1β) and interleukin-8 (IL-8) were examined at different time points. Both live M. viscosa cells and ECP were cytotoxic, but neither heat-killed cells, nor the MvP1 peptidase caused cell death. Expression levels of both IL-1β and IL-8 increased significantly after stimulation with live cells, but heat-killed cells only caused increased IL-8 expression. ECP did not affect IL-1β expression, but did stimulate IL-8 expression. The isolated MvP1 peptidase stimulated both IL-1β and IL-8 expression at the highest concentration tested. This study reveals a difference in the induction of pro-inflammatory gene expression in salmon SHK-1 cells between live and heat-killed M. viscosa cells, and also that an unknown secreted factor is the main stimulant of IL-β and IL-8 expression.ID: S1050464809000990; M3: Article; Accession Number: S1050464809000990; Author: Bryndis Bjornsdottir (a, b); Author: Mark D. Fast (b, 1); Author: Sandra A. Sperker (b); Author: Laura L. Brown (b, 2); Author: Bjarnheidur K. Gudmundsdottir (a, ∗); Affiliation: Institute for Experimental Pathology, University of Iceland, Keldur v/Vesturlandsveg, 112 Reykjavík, Iceland; Affiliation: National Research Council Canada, Institute for Marine Biosciences, 1411 Oxford Street, Halifax, Nova Scotia B3H 2Z1, Canada; Keyword: Moritella viscosa; Keyword: Extracellular products; Keyword: MvP1 vibriolysin; Keyword: Atlantic salmon; Keyword: SHK-1; Keyword: Gene expression; Keyword: Immune response; Keyword: Pro-inflammatory cytokine; Keyword: Interleukin-1β (IL-1β); Keyword: Interleukin-8 (IL-8); Number of Pages: 6; Language: English;Source type: Electronic(1
The value of subject specialization and the future of science liaison librarianship
No full textThrough a survey of over 200 U.S. academic science librarians, we investigate the perceived value of subject specialization; look for trends toward or away from science subject specialization; and analyze predictions about the future of science liaison librarianship. Results show that science librarians perceive subject specialization positively and predict it will continue to be necessary in the future. They also perceive that liaison relationships will remain crucial. While functional roles appear to be growing, they were not seen as replacing traditional subject responsibilities. Results suggest a shift toward a more generalist approach, however, additional research is needed before stating this conclusively.Peer reviewe
Pilot-Scale Assessment of a Novel Farrowing Creep Area Supplementary Heat Source
No full textPre-weaning morality (PWM) is attributed to a poor creep area microclimate and causes major economic and productivity losses for the US swine industry. Piglets need supplementary heat to overcome a high surface area to body weight ratio and minimal thermoregulation. A pilot-scale study was conducted to evaluate a semi-enclosed heated microclimate (SEHM) as a supplementary heat source for farrowing creep areas over six farrowing cycles (from January to July 2019) in two rooms with 24 farrowing stalls in each room. Six SEHMs (each SEHM covers two stalls) were randomly distributed to each room and compared to heat lamps (HLs) for productivity and electricity usage. Data from 113 (SEHM) and 101 litters (HL) showed no significant difference between treatments in average daily gain (p = 0.26), 252.4 ± 8.0 g hd−1 d−1 (SEHM) and 260.3 ± 8.1 g hd−1 d−1 (HL) and PWM (p = 0.08), 9.67% ± 0.82% (SEHM) and 12.04% ± 0.87% (HL). However, a significant difference (p = 0.02) was noted in the PWM attributed to over-lay mortalities, 4.05% ± 0.76% (SEHM) compared to 6.04% ± 0.78% (HL). The SEHM electricity averaged 3.25 kWh d−1 (2.91, 3.59 kWh d−1; 95% CI), which was significantly different (p −1).This article is published as Smith, Benjamin C., Brett C. Ramirez, Steven J. Hoff, and Laura L. Greiner. "Pilot-Scale Assessment of a Novel Farrowing Creep Area Supplementary Heat Source," Animals 9, no. 11 (2019): 996. DOI: 10.3390/ani9110996. Posted with permission.</p
Cross-ethnic measurement invariance of the SCARED and CES-D in an ethnically diverse youth sample
No full textThis study evaluated the cross-ethnic measurement invariance of two common screening measures of anxiety and depressive symptoms in youth. The measurement invariance of the Screen for Childhood Anxiety and Related Emotional Disorders (SCARED) and the Center for Epidemiologic Studies Depression Scale (CES-D) was tested across 881 African American (n = 396), Latino (n = 185), Non-Hispanic White (n = 166), and Asian/Indian (n = 134) youths in the seventh grade. The measures were administered as part of a grade-wide screening aimed to identify youth with elevated anxiety and depressive symptoms. The five-factor model of the SCARED and the four-factor model of the CESD best represented the data for all ethnic groups. Results provided support for scalar equivalence of the SCARED across all four ethnic groups. Results provided support for scalar equivalence of the CES-D across African American (AA), Non-Hispanic White (NHW), and Asian/Indian youths, and partial invariance for Hispanic youths. Factor mean differences across groups were identified for both measures. In particular, Hispanic youth reported greater levels of anxiety and depression in certain domains than NHW, AA, and Asian youth. Our findings support the use of the SCARED and CESD as tools for measuring anxiety and depressive symptoms in ethnically diverse youth in the U.S. Results are discussed with respect to the importance of establishing measurement invariance for screening measures of anxiety and depressive symptoms prior to comparing symptom levels across ethnic.M.S.Includes bibliographical referencesby Laura C. Skrine
Dataset for paper "Technology for monitoring everyday prosthesis use: a systematic review"
No full textThis dataset supports the publication:
A Chadwell, L Diment, M E Mico-Amigo, D Z Morgado Ramirez, A Dickinson, M Granat, L Kenney, S Kheng, M Sobuh, R Ssekitoleko, P Worsley. (2020) Technology for monitoring everyday prosthesis use: a systematic review. Journal of NeuroEngineering and Rehabilitation. DOI: https://doi.org/10.1186/s12984-020-00711</span
sj-csv-2-hpq-10.1177_13591053231213305 – Supplemental material for Post-traumatic stress in older, community-dwelling adults with hypertension during the COVID-19 pandemic: An investigation of pre-pandemic sociodemographic, health, and vascular and inflammatory biomarker predictors
No full textSupplemental material, sj-csv-2-hpq-10.1177_13591053231213305 for Post-traumatic stress in older, community-dwelling adults with hypertension during the COVID-19 pandemic: An investigation of pre-pandemic sociodemographic, health, and vascular and inflammatory biomarker predictors by Emily A Troyer, Jordan N Kohn, Monica Feliz R Castillo, Judith D Lobo, Yaniel Ramirez Sanchez, Gavrila Ang, Anthony Cirilo, Juan Andrew Leal, Christopher Pruitt, Amanda L Walker, Kathleen L Wilson, Meredith A Pung, Laura S Redwine and Suzi Hong in Journal of Health Psychology</p
sj-docx-1-tab-10.1177_1759720X221114105 – Supplemental material for Plasma calprotectin as a biomarker of ultrasound synovitis in rheumatoid arthritis patients receiving IL-6 antagonists or JAK inhibitors
No full textSupplemental material, sj-docx-1-tab-10.1177_1759720X221114105 for Plasma calprotectin as a biomarker of ultrasound synovitis in rheumatoid arthritis patients receiving IL-6 antagonists or JAK inhibitors by Beatriz Frade-Sosa, Andrés Ponce, José Inciarte-Mundo, Rosa Morlà, Viginia Ruiz-Esquide, Laura Macías, Ana Belen Azuaga, Julio Ramirez, Juan D. Cañete, Jordi Yague, Josep M. Auge, José A. Gomez-Puerta and Raimon Sanmarti in Therapeutic Advances in Musculoskeletal Disease</p
sj-pdf-3-hpq-10.1177_13591053231213305 – Supplemental material for Post-traumatic stress in older, community-dwelling adults with hypertension during the COVID-19 pandemic: An investigation of pre-pandemic sociodemographic, health, and vascular and inflammatory biomarker predictors
No full textSupplemental material, sj-pdf-3-hpq-10.1177_13591053231213305 for Post-traumatic stress in older, community-dwelling adults with hypertension during the COVID-19 pandemic: An investigation of pre-pandemic sociodemographic, health, and vascular and inflammatory biomarker predictors by Emily A Troyer, Jordan N Kohn, Monica Feliz R Castillo, Judith D Lobo, Yaniel Ramirez Sanchez, Gavrila Ang, Anthony Cirilo, Juan Andrew Leal, Christopher Pruitt, Amanda L Walker, Kathleen L Wilson, Meredith A Pung, Laura S Redwine and Suzi Hong in Journal of Health Psychology</p
sj-docx-1-hpq-10.1177_13591053231213305 – Supplemental material for Post-traumatic stress in older, community-dwelling adults with hypertension during the COVID-19 pandemic: An investigation of pre-pandemic sociodemographic, health, and vascular and inflammatory biomarker predictors
No full textSupplemental material, sj-docx-1-hpq-10.1177_13591053231213305 for Post-traumatic stress in older, community-dwelling adults with hypertension during the COVID-19 pandemic: An investigation of pre-pandemic sociodemographic, health, and vascular and inflammatory biomarker predictors by Emily A Troyer, Jordan N Kohn, Monica Feliz R Castillo, Judith D Lobo, Yaniel Ramirez Sanchez, Gavrila Ang, Anthony Cirilo, Juan Andrew Leal, Christopher Pruitt, Amanda L Walker, Kathleen L Wilson, Meredith A Pung, Laura S Redwine and Suzi Hong in Journal of Health Psychology</p
sj-pdf-5-hpq-10.1177_13591053231213305 – Supplemental material for Post-traumatic stress in older, community-dwelling adults with hypertension during the COVID-19 pandemic: An investigation of pre-pandemic sociodemographic, health, and vascular and inflammatory biomarker predictors
No full textSupplemental material, sj-pdf-5-hpq-10.1177_13591053231213305 for Post-traumatic stress in older, community-dwelling adults with hypertension during the COVID-19 pandemic: An investigation of pre-pandemic sociodemographic, health, and vascular and inflammatory biomarker predictors by Emily A Troyer, Jordan N Kohn, Monica Feliz R Castillo, Judith D Lobo, Yaniel Ramirez Sanchez, Gavrila Ang, Anthony Cirilo, Juan Andrew Leal, Christopher Pruitt, Amanda L Walker, Kathleen L Wilson, Meredith A Pung, Laura S Redwine and Suzi Hong in Journal of Health Psychology</p
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