323,061 research outputs found
Forme giuridiche per lo sviluppo economico delle Aree interne: la prospettiva civilistica
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Embedding of superelastic shape memory alloy wires into composite structures: evaluation of impact properties
No full textGenotoxic and cytotoxic effects of ZnO nanoparticles for Dunaliella tertiolecta and comparison with SiO2 and TiO2 effects at population growth inhibition levels
No full textThe increasing use of oxide nanoparticles (NPs) in commercial products has intensified the potential release into the aquatic environment where algae represent the basis of the trophic chain. NP effects upon algae population growth were indeed already reported in literature, but the concurrent effects at cellular and genomic levels are still largely unexplored.Our work investigates the genotoxic (by COMET assay) and cytotoxic effects (by qualitative ROS production and cell viability) of ZnO nanoparticles toward marine microalgae Dunaliella tertiolecta. A comparison at defined population growth inhibition levels (i.e. 50% Effect Concentration, EC50, and No Observed Effect Concentration, NOEC) with SiO2 and TiO2 genotoxic effects and previously investigated cytotoxic effects (Manzo et al., 2015) was performed in order to elucidate the possible diverse mechanisms leading to algae growth inhibition.After 72 h exposure, ZnO particles act firstly at the level of cell division inhibition (EC50: 2 mg Zn/L) while the genotoxic action is evident only starting from 5 mg Zn/L. This outcome could be ascribable mainly to the release of toxic ions from the aggregate of ZnO particle in the proximity of cell membrane.In the main, at EC50 and NOEC values for ZnO NPs showed the lowest cytotoxic and genotoxic effect with respect to TiO2 and SiO2. Based on Mutagenic Index (MI) the rank of toxicity is actually: TiO2 > SiO2 > ZnO with TiO2 and SiO2 that showed similar MI values at both NOEC and EC50 concentrations.The results presented herein suggest that up to TiO2 NOEC (7.5 mg/L), the algae DNA repair mechanism is efficient and the DNA damage does not result in an evident algae population growth inhibition. A similar trend for SiO2, although at lower effect level with respect to TiO2, is observable.The comparison among all the tested nanomaterial toxicity patterns highlighted that the algae population growth inhibition occurred through pathways specific for each NP also related to their different physicochemical behaviors in seawater. © 2016 Elsevier B.V.
Safety and efficacy of rotational atherectomy in heavily calcified lesions involving coronary aneurysms
No full textPercutaneous transluminal rotational atherectomy (PTRA) is one of the most used techniques to facilitate percutaneous coronary intervention in heavily calcified coronary lesion (CCL). Coronary aneurysms (CAs) are detected in 1.2-4.9% of coronary angiogram. The presence of CA and CCL is infrequent but not rare, where the use of PTRA may be mandatory despite the high risk. After a complex procedure of PTRA in a CCL with CA we decided to investigate about this particular condition. We identified a total of six patients among 174 consecutive percutaneous coronary intervention (3.4%). All the procedures showed good stent expansion in the absence of major complications, such as no-reflow or coronary perforation. Cardiovascular death, rehospitalization for myocardial infarction and target lesion failure were not reported at follow-up (252 +/- 152 days).
Lay abstract Fat and other substances can build up within blood vessels and block them. There are a few ways to remove this blockage, including a procedure known as percutaneous transluminal rotational atherectomy (PTRA). During PTRA, doctors use a rotating catheter (a soft, hollow tube) whose tip is covered with fine diamond crystals. This will help to vaporize the buildup. However, this process can have some complications, especially when carried out in fragile blood vessels. This paper describes a patient where PTRA was performed in a fragile blood vessel and goes on to investigate other occurrences of this high-risk procedure. We were able to find six patients out of 174 procedures performed at two hospitals in Italy. All of these patients did not have serious side effects from their operation
Inherited variants of genes involved in insulin signalic and lipogenesis influence the risk of hepatic fibrosis in nonalcoholic fatty liver disease
No full textGenotype of the transcription factor FOXO1 medianting insulin signaling influences the susceptibility to and severity of nonalcoholic fatty liver disease by modulatine FOXO1 MRNA levels
No full textInherited variants of genes involved in insulin signaling and lipogenesis influence the risk of hepatic fibrosis in nonalcoholic fatty liver disease
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