9 research outputs found
Parliamentary Contribution of Hon. Ramesh Pathirana, Minister of Plantations and Export Agriculture
No full textThis infographic is available in English and Sinhala.Ramesh Pathirana appointed as minister of plantations and export agriculture in 22nd of November 2019.
This infographic depicts his parliamentary contribution regarding plantations and minor export crops as a member of parliament from September 2015 - September 201
Cabinet Reshuffle: Parliamentary Report Cards of Newly Appointed Ministers
No full textThis infographic is available in English and Sinhala.On October 23, 2023, a cabinet reshuffle took place, during which the ministerial portfolios of four MPs - Keheliya Rambukwella, Ramesh Pathirana, Ranjith Siyambalapitiya and Mahinda Amaraweera - were changed. Considering this, VR's Manthri Team analysed their performance during the 8th and 9th parliament. It is based on analysis of Hansard data from September 2015 to February 2020 and August 2020 to August 2023. This includes overall ranks, district ranks, attendance in parliament sittings, total number of productive interventions they made in 8th and 9th parliaments. The topics they have contributed most are Justice, Defense & Public Order, Economy and Finance, Governance, Administration and Parliamentary Affairs, Trade & Industry, Education, Natural Resources & Environment, Agriculture, Plantations, Livestock & Fisheries, Health, Technology, Communications & Energy and Urban Planning, Infrastructure and Transportation
Compact core drilling in basalt rock using PCD tool inserts: Wear characteristics and cutting forces
No full textThe hardest component of the Martian surface is believed to be basalt rock, which is highly abrasive in nature. It will be important to operate a Martian drill under conditions that are conducive to minimal tool wear. In preparation for a Mars drilling project, this paper reports results of an experimental study of dry drilling in basalt and related tool wear. It also reports the effect of the tool wear on increasing the forces and torques required when drilling in basalt rock (on earth) using polycrystalline diamond (PCD) compact core drill inserts. Force and torque data measured for a variety of cutting conditions are shown along with experimental wear data obtained while drilling in basalt rock having different strengths. It is found that flank wear, VB, and cutting edge radius, CER, wear rates increase with rock strength, VB-wear rates and CER-wear rates exhibit opposite trends in their dependence on the remainder of the cutting parameters. For example, while VB-wear rates decrease with an increase in tool feed and spindle speed values, CER-wear rates increase with increases in tool feed and remains unchanged with increases in spindle speed. VB-wear rates decrease as the rake angle becomes more negative, while CER-wear rates increase as this occurs. It is found that basalt rock strength manifests itself via larger (smaller) generated forces-torques for rocks of harder (softer) composition. Strong correlations are found between both modes of tool wear (VB and CER) and the measured values of thrust force and torque. Equations for progressive tool wear as functions of the process variables are developed. A model for the changing drill forces and torques required by the progressive tool wear is developed for drilling in basalt. © 2010 Elsevier B.V. All rights reserved.Balakrishnan P., 1985, Transactions of the ASME. Journal of Engineering for Industry, V107; Bar-Cohen Y, 2001, P SOC PHOTO-OPT INS, V4327, P441, DOI 10.1117-12.436556; Belmonte M, 2004, DIAM RELAT MATER, V13, P843, DOI 10.1016-j.diamond.2003.11.018; Checkina OG, 1996, WEAR, V198, P33, DOI 10.1016-0043-1648(95)06912-7; Choudhury SK, 2000, INT J MACH TOOL MANU, V40, P899, DOI 10.1016-S0890-6955(99)00088-7; CLAYTON R, 2005, SPE IADC DRILL C 23; DAGRAIN F, 2006, P INT S INT SOC ROCK, P577; Detournay E, 2008, INT J ROCK MECH MIN, V45, P1347, DOI 10.1016-j.ijrmms.2008.01.010; DETOURNAY E, 1992, INT J ROCK MECH MIN, V29, P13, DOI 10.1016-0148-9062(92)91041-3; ERSOY A, 1995, WEAR, V188, P150, DOI 10.1016-0043-1648(95)06646-2; Fergason RL, 2006, J GEOPHYS RES-PLANET, V111, DOI 10.1029-2005JE002583; Finzi AE, 2004, PLANET SPACE SCI, V52, P83, DOI 10.1016-j.pss.2003.08.018; Glowka D. A., 1986, SPE DRILLING ENG, V1, P201; GLOWKA DA, 1989, J PETROL TECHNOL, V41, P797; GLOWKA DA, 1987, SAND861745UC66 SANDI; HEAP MJ, 2007, GEOPH RES ABSTR, V9; HIBBS LE, 1978, WEAR, V46, P141, DOI 10.1016-0043-1648(78)90116-3; HOUGH CL, 1985, J ENERG RESOUR-ASME, V107, P534; Jantunen E, 2002, INT J MACH TOOL MANU, V42, P997, DOI 10.1016-S0890-6955(02)00040-8; JAWAHIR IS, 1995, ANN CIRP, V44, P49; JONAK K, 2001, J MIN SCI+, V37, P615; KANAI M, 1988, ANN CIRP, V27, P61; Li KM, 2007, INT J MACH TOOL MANU, V47, P1292, DOI 10.1016-j.ijmachtools.2006.08.017; Li XS, 2005, WEAR, V259, P1128, DOI 10.1016-j.wear.2005.02.091; Liang Q, 2008, DIAM RELAT MATER, V17, P2041, DOI 10.1016-j.diamond.2008.06.008; LIN TP, 1992, WEAR, V156, P133; MACKINNON R, 1986, P 26 INT MACH TOOL D, P317; MANTHRI SP, 2007, MECH ENG; Martin JA, 1997, INT J ROCK MECH MIN, V34, P59; MATLAB [Computer software], MATLAB; MATTI H, 1999, ROCK EXCAVATION HDB; Moseley SG, 2009, INT J REFRACT MET H, V27, P394, DOI 10.1016-j.ijrmhm.2008.11.014; OKUBO S, 1999, J MINING MAT PROCESS, V115, P669; ORABY SE, 1991, INT J MECH SCI, V33, P125, DOI 10.1016-0020-7403(91)90062-8; Oraby SE, 2004, INT J MACH TOOL MANU, V44, P1261, DOI 10.1016-j.ijmachtools.2004.04.018; ORTEGA A, 1980, SAND802677 SAND NAT; PARISEAU WG, 2007, DESIGN ANAL ROCK MEC, P486; Plinninger R.J, 2002, P 9 C INT ASS ENG GE; Remadna M, 2006, J MATER PROCESS TECH, V178, P67, DOI [10.1016-j.jmatprotec.2005.03.038, 10.1016-j.jmatprotee.2005.03.038]; Selby M. J., 1993, HILLSLOPE MAT PROCES; Shaw M. C., 1957, T ASME, V79, P139; Sinor A., 1989, SPE DRILLING ENG, V4, P128; Smithey DW, 2000, INT J MACH TOOL MANU, V40, P1929, DOI 10.1016-S0890-6955(00)00017-1; SUBRAMANIAN K, 1977, T ASME, V101, P295; Tarasov K. I., 1974, Molochnaya Promyshlennost', P15; Taylor F.W., 1907, T ASME, V28, P31; TIPNIS VA, 1976, P 4 NAMRC, P279; Vervoort A, 1997, ENG GEOL, V47, P259, DOI 10.1016-S0013-7952(97)00023-9; ZACNY KA, 2007, INT J MARS SCI EXPLO, V3, P1; Zacny KA, 2005, J GEOPHYS RES-PLANET, V110, DOI 10.1029-2004JE002340; Zacny KA, 2007, J GEOPHYS RES-PLANET, V112, DOI 10.1029-2005JE002538; Zacny KA, 2005, J GEOPHYS RES-PLANET, V110, DOI 10.1029-2004JE002341; Zacny KA, 2004, J GEOPHYS RES-PLANET, V109, DOI 10.1029-2003JE00220466
A methodology for the optimization of PCD compact core drilling in basalt rock
No full textThis work presents an optimization technique using genetic algorithm for efficient core drilling in basalt rock. Optimization of the compact core-drilling problem is based on maximizing a desirability function which accounts for (a) maximizing the drilling feed while minimizing tool-wear progression, (b) minimizing the thrust force and torque (power), and (c) satisfying realistic constraints related to process parameters. The resulting set of optimized cutting parameters is sought in order to make the tool last longer while effectively drilling with high productivity. A room temperature model to relate the experimental data on changing drill forces and torques required by the progressive tool wear, and developed in a previous paper, is used in this study. © 2011 Springer-Verlag London Limited.Ali-Tavoli M, 2006, MACH SCI TECHNOL, V10, P491, DOI 10.1080-10910340600996126; Bourgoyne Jr A.T., 1974, T AIME SOC PET ENG J, V257, P371; Choudhury SK, 2000, INT J MACH TOOL MANU, V40, P899, DOI 10.1016-S0890-6955(99)00088-7; Clayton R, 2005, SPE IADC DRILL C P A; Fergason RL, 2006, J GEOPHYS RES-PLANET, V111, DOI 10.1029-2005JE002583; Fernandes M, 2006, INT J MACH TOOL MANU, V46, P76, DOI 10.1016-j.ijmachtools.2005.03.016; GLOWKA DA, 1989, J PETROL TECHNOL, V41, P850; GLOWKA DA, 1989, J PETROL TECHNOL, V41, P797; Hamade R. F., 2009, P ASME INT MECH ENG; Hamade RF, 2008, CIRP ICME 08 NAPL IT; Hamade RF, 2010, J MATER PROCESS TECH, V210, P1326, DOI 10.1016-j.jmatprotec.2010.03.023; Hamade RF, 2006, INT J MACH TOOL MANU, V46, P387, DOI 10.1016-j.ijmachtools.2005.05.016; Holland John Henry, 1992, ADAPTATION NATURAL A; Judzis A, 2009, SPE DRILL COMPLETION, V24, P25; Lia ZC, 2005, INT J MACH TOOL MANU, V45, P1402; MALAKOOTI B, 1989, OPER RES, V37, P805, DOI 10.1287-opre.37.5.805; Myers RH, 1995, PROBABILITY STAT SER; Plinninger RJ, 2004, EUROCK 2004 53 GEOM; Plinninger RJ, 2002, 9 P C INT ASS ENG GE, P2226; Sardinas RQ, 2006, ENG APPL ARTIF INTEL, V19, P127, DOI 10.1016-j.engappai.2005.06.007; Tulu IB, 2008, 42 US ROCK MECH 2 US; VENET V, 1993, REV I FR PETROL, V48, P15; Wang X, 2005, INT J PROD RES, V43, P3543, DOI 10.1080-13629390500124465; Weaver GE, 2000, US Patent, Patent No. 6109368; WOJTANOWICZ AK, 1993, J ENERG RESOUR-ASME, V115, P247, DOI 10.1115-1.2906429; Yinghui Liu, 2007, Journal of Manufacturing Science and Engineering, V129, DOI 10.1115-1.2515345; Zacny KA, 2004, J GEOPHYS RES-PLANET, V109, DOI 10.1029-2003JE002204; Zhang JY, 2006, J INTELL MANUF, V17, P203, DOI 10.1007-s10845-005-6637-z11
Epistatic interactions among <i>CYP2C19*2, CYP3A4</i> and <i>GSTP1</i> on the cyclophosphamide therapy in lupus nephritis patients
No full text Aim: To investigate the impact of genetic variants in CYP2C9, CYP2C19, CYP3A4, GSTT1, GSTM1 and GSTP1 on the efficacy of cyclophosphamide (CYC) therapy in patients with lupus nephritis. Materials & methods: Lupus nephritis patients (n = 220) treated with CYC were included in the study. Results: Logistic regression analysis identified CYP2C19*2 as an independent predictor of CYC therapeutic failure (odds ratio [OR]: 2.69; p = 0.0043). Bivariate and trivariate analysis showed the subjects harboring CYP2C19*2 and GSTP1 (OR: 3.25; p = 0.03), and CYP2C19*2, GSTP1 and CYP3A5*3 have synergistic influence on CYC failure (OR: 8.2; p < 0.0001). Significant decrease in AUC0-t, Cmax and t½ of 4-OH-CYC in patients carrying CYP3A5*3 (p < 0.02). Conclusion: Patients with CYP2C19*2 were at increased risk and CYP2C19*2, CYP3A5*3 and GSTP1 have synergistic influence on CYC failure. </jats:p
Author Correction:Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis (Nature, (2018), 560, 7717, (192-197), 10.1038/s41586-018-0356-z)
No full textCorrection to: Nature Published online 25 July 2018 During the publication process, the authors mistakenly included the wrong image for Fig. 3c. The correct Fig. 3c is shown as Fig. 1 below. The error is in presentation and makes no material difference to the scientific conclusions. The values shown in the legend for Fig. 3c and in the supporting information (Table S8) remain correct. We would like to acknowledge the anonymous scientist who pointed out the error. (Figure presented.) .</p
Assessment of Enterovirus Excretion and Identification of VDPVs in Patients with Primary Immunodeficiency in India: Outcome of ICMR–WHO Collaborative Study Phase-I
No full textThe emergence of vaccine-derived polioviruses (VDPVs) in patients with Primary Immunodeficiency (PID) is a threat to the polio-eradication program. In a first of its kind pilot study for successful screening and identification of VDPV excretion among patients with PID in India, enteroviruses were assessed in stool specimens of 154 PID patients across India in a period of two years. A total of 21.42% of patients were tested positive for enteroviruses, 2.59% tested positive for polioviruses (PV), whereas 18.83% of patients were positive for non-polio enteroviruses (NPEV). A male child of 3 years and 6 months of age diagnosed with Hyper IgM syndrome was detected positive for type1 VDPV (iVDPV1) with 1.6% nucleotide divergence from the parent Sabin strain. E21 (19.4%), E14 (9%), E11 (9%), E16 (7.5%), and CVA2 (7.5%) were the five most frequently observed NPEV types in PID patients. Patients with combined immunodeficiency were at a higher risk for enterovirus infection as compared to antibody deficiency. The high susceptibility of PID patients to enterovirus infection emphasizes the need for enhanced surveillance of these patients until the use of OPV is stopped. The expansion of PID surveillance and integration with a national program will facilitate early detection and follow-up of iVDPV excretion to mitigate the risk for iVDPV spread
Nurse-led pre-travel health consultations : evaluating current practice and developing a new model
No full textThis study explores the pre-travel consultation between nurses and people who
plan to travel abroad from the UK. Travel health services have developed ad hoc
in response to rising public demand, and are mainly nurse-led in UK general
practice. There is little research evidence to describe or evaluate pre-travel
healthcare provision.
Using a mainly qualitative bricolage design of six methods, the research traces
the ‘journey’ of health recommendations made to travellers. Starting with guidance
documents produced by experts, it then tracks the fulfilment of these
recommendations through consultations conducted by nurses and captures the
ways in which travellers use or discard the recommendations while travelling. It
explores the clinical reasoning behind activities in pre-travel consultations, and
generates ideas for practice development.
The key findings are that pre-travel healthcare is medicine-centric and issues of
time, organisation, and the model adopted by nurses affects the quality of
consultations. Two styles of consultation were identified: the Kitchen Sink style
was comprehensive and verbose; the Medical and Minimal style focused on
vaccinations. Travellers recalled or used very little of what was imparted during
their consultations, but far from being ‘blank slates’, travellers usually managed
their health appropriately and had far more knowledge than nurses recognised.
The thesis offers conceptual insights to the pre-travel consultation which relate to
patient safety, quality and the legal integrity of practitioners. It offers a prototype
model of the pre-travel consultation that takes account of the challenges
associated with current practice.
The implications for practice relate to education for nurses in consultation
management, patient-centredness, proactive versus reactive service provision,
and patient education. PRE-TRAVEL - the new model for consultations -
contributes a framework for engaging with these issues, subject to post-doctoral
testing
