131 research outputs found
Author Correction: COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials
No full textIn the original version of this Perspective, the name of the author Giuseppe Curigliano was incorrectly written as Guiseppe Curigiliano. The affiliations have been corrected in the HTML and PDF versions of the manuscrip
Synthesis, characterization, crystal structure and NLO properties of a new mixed crystal potassium sodium ammonium dihydrogenphosphate K0.23Na0.23(NH4)0.54H2PO4
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Development of novel small molecules as therapeutics for inflammatory diseases and delineating their molecular mechanisms
No full textDuring any infection or injury, inflammation plays a vital role in curing the injured tissues. However, uncontrolled inflammatory
responses due to defects in pro-resolution and anti-inflammatory processes can be detrimental and lead to many diseases, including
gastrointestinal, liver, lung and brain disorders. Although many approved anti-inflammatory drugs are currently in clinical use,
long-term usage of anti-inflammatory drugs is associated with many side effects, including gastrointestinal toxicity and adverse
effects on the cardiovascular system. Hence, understanding and advancing in the field of small molecules is a better way to tackle
this clinical problem with anti-inflammatory drugs. This special issue has collectively published research and review articles
focusing on inflammation and small molecule therapeutics with a larger perspective to generate ideas for future scientific and
clinical research. We are hopeful that the small molecule-based therapeutic approaches discussed here will evolve more into
routine clinical practice in near future
Author Correction: EGFR and HER2 exon 20 insertions in solid tumours: from biology to treatment (Nature Reviews Clinical Oncology, (2022), 19, 1, (51-69), 10.1038/s41571-021-00558-1)
No full textNovel Simulator for Wireline Mini-Fracture Testing
No full textWireline Mini-Fracture testing jobs consist of a short duration, small volume fracturing operation inside an open-hole borehole, where a certain amount of fluid is injected into the formation at constant rate using a Wireline Modular conveyed tool as a source of hydraulic power to pressurize the wellbore. The tool is configured with an inflatable straddle packer and an internal pump, which inflate/deflates the packers and supplies pressure to the formation until a hydraulic fracture is induced. This procedure is used to determine in–situ formation breakdown and closure pressure also known as minimum horizontal closure pressure. This provides vital information regarding hydraulic fracture design, water and gas injection management, fault re-activation, wellbore stability, sand production, rock mechanical properties, casing string design, cap and base rock integrity and gas storage design. Geomechanical and operational parameters such as, elastic properties, poro-elasticity, rock strength, formation pore pressure, far field horizontal stress, permeability/porosity distributions, borehole fluid properties among others, influences the performance of the Mini-Frac Jobs. In many cases poor understanding of the reservoir response to the fracture process, caused that the hydraulic fracture did not propagate deep into the formation. In other cases the pressure applied to the formation might be insufficient to break down the formation, leading to unsatisfactory application of the Mini-Fracture technique in the process. The objective of this thesis is to develop a Mini-Facture application simulator that uses the geomechanical and operational parameters that control the performance of a Mini-Fracture job and estimate the possibility of the occurrence of a tensile failure in the formation. The simulator is then validated by comparing its output with the results of stress test done in the field. With this simulator petrotechnical professionals and field engineers will have a platform that simulates the pressure responses and fracture initialization during Mini-Frac treatments, incorporating all the variables affecting a Wireline Mini-Fracture job, helping the design engineer to make key decisions about the ultimate or required fracture plan. Furthermore the simulator will reduce the uncertainties that limit the reliability of the Wireline Mini-Fracture treatment by allowing the selection of appropriate tool configuration based on the job objectives and the geological environmental conditions. Finally this project demonstrates that combining the appropriate constitutive relations that reflect the coupling among the tool operational performance with wellbore flow, reservoir and geomechanics modelling a Mini-Fracture simulator can be developed.Petroleum EngineeringGeoscience & EngineeringCivil Engineering and Geoscience
Effect of doping cations Li(I)-, Ca(II)-, Ce(IV)- and V(V)- on the properties and crystalline perfection of potassium dihydrogen phosphate crystals: A comparative study
No full textThe effect of doping metal ions with varied ionic charges (ranging from +1 to +5), Li(I)-, Ca(II)-, Ce(IV)- and V(V)on the growth process and properties of potassium dihydrogen phosphate (KDP) crystals, grown by slow evaporation solution growth technique, has been investigated. Incorporation of metal ion into the KDP crystalline matrix is well confirmed by energy dispersive X-ray spectroscopy and atomic absorption spectroscopy. Interesting to observe that the incorporation is comparatively less in doping the higher valent metal. The powder XRD pattern and Fourier transform-IR analysis confirm the slight distortion in the structure of the KDP crystals as a result of metal ion doping. Slight changes in cell parameter values of doped KDP crystals are observed by single crystal XRD analysis. The high-resolution X-ray diffraction (HRXRD) studies used to evaluate the crystalline perfection reveal many interesting features on the ability of accommodating the dopants by the crystalline matrix. Surface morphological changes because of foreign metal ion incorporation are observed by scanning electron microscopy. UV-Vis spectroscopy reveals that the transparency is not affected much by the dopants and the cut-off wavelengths of all the doped specimens lie in a close range. Band-gap energies are estimated using optical transmittance data. Enhanced second harmonic generation efficiency is observed
Information Technology: Equalizer or Separator of Developing Countries?
No full textThe author discusses about the Information technology scenario in developing countries
China promotes traditional medicine
No full textThe author reports the promotional activities undertaken by China in the field of traditional medicine
A Path to Protein Quantitation: PBMCs to Western Blot
No full textProteins are biopolymers made up of one or more long chains of amino acid residues. These proteins mediate thousands of metabolic pathways that determine how an organism functions. When proteins are thoroughly investigated, they can provide information about health and disease. A variety of methods have been developed to quantify both complex protein mixtures for total protein content as well as a single type of protein. This manuscript covers the methodologies standardized in our lab based on previously published protocols, beginning with the isolation of peripheral blood mononuclear cells (PBMCs) from human blood samples, cell viability testing, cell counting, total protein extraction methods, and protein quantification and estimation techniques, which enable a researcher to find the protocol from PBMCs to Western blot in a single manuscript
Optimization and Development of Magnetically Triggered Letrozole Nanoliposomes for Breast Cancer Targeting
No full textBackground: Breast cancer is one of the most frequently diagnosed cancers and is the leading cause of death among women worldwide [...
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