181 research outputs found
Surgical suturing-induced melanocytic nevi. A new type of eruptive melanocytic nevi?
No full textNevogenesis is a complex process involving several pathogenetic mechanisms, including genetic factors, hormonal influences and UV-radiation. Trauma has been described as a triggering factor for an alternative pathway of nevogenesis. Eruptive melanocytic nevi (EMN), related either to immunosuppression or to blistering disorders, represent a special type of nevi probably induced by the disruption of the dermo-epidermal junction and consequent proliferation of quiescent pigment cells during re-epithelization
Coexistent Psoriasis and Bullous Pemphigoid Responding to Mycophenolate Mofetil Monotherapy
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Giant plexiform neurofibroma in a patient with neurofibromatosis type I
No full textOverview of the Author Profiling Task at PAN 2013
Get PDF[EN] This overview presents the framework and results for the Author Profiling
task at PAN 2013. We describe in detail the corpus and its characteristics,
and the evaluation framework we used to measure the participants performance to
solve the problem of identifying age and gender from anonymous texts. Finally,
the approaches of the 21 participants and their results are described.The author profiling task @PAN-2013 was an activity of the WIQ-EI IRSES project (Grant No. 269180) within the FP 7 Marie Curie People Framework of the European Commission. We want to thank the Forensic Lab of the Universitat Pompeu Fabra Barcelona for sponsoring the award for the winner team. The work of the first author was partially funded by Autoritas Consulting SA and by Ministerio de Economía y Competitividad de España under grant ECOPORTUNITY IPT-2012-1220-430000. The work of the second author was in the framework the DIANA-APPLICATIONS-Finding Hidden Knowledge in Texts: Applications (TIN2012-38603-C02-01) project, and the VLC/CAMPUS Microcluster on Multimodal Interaction in Intelligent Systems. The work of fifth author was funded in part by the Swiss National Science Foundation (SNF) project "Mining Conversational Content for Topic Modelling and Author Identification (ChatMiner)" under grant number 200021_130208.Rangel, F.; Rosso, P.; Koppel, M.; Stamatatos, E.; Inches, G. (2013). Overview of the Author Profiling Task at PAN 2013. CLEF Conference on Multilingual and Multimodal Information Access Evaluation. 352-365. https://riunet.upv.es/handle/10251/46636S35236
Malignant syphilis as the first manifestation of HIV infection
No full textMalignant syphilis is a rare and severe variant of secondary syphilis. It is clinically characterized by large papular, nodular and ulcerative lesions affecting the trunk and the extremities and covered with thick crust. We present a case of 52-year-old homosexual male who developed malignant syphilis and this was the first clinical manifestation of HIV infection. The patient was treated successfully with intravenous aqueous crystalline penicillin G. Physicians should recognize malignant syphilis and considered it in all HIV-infected individuals with ulceronodular skin lesions
The functional morphology of the skin during the appearance of drug iduced eruptions: a precursor study with light and electron microscope
No full textIn our study 25 patients clinically diagnosed as having cutaneous drug reactions were examined with light microscopy and 11 of them with both light and electron microscopy. The results are summarized into the following: 1. Clinical criteria are not sufficient enough to establish the diagnosis of drug eruptions. In our study, only 23 out of 25 patients (92%) were proved to manifest drug eruptions. 2. The cutaneous adverse drug reactions are not encountered in female group as far as 14 patients were men (60,86%) and 9 women (39,13%). Our findings were not in agreement with the majority of literature. 3. The mean age of our patients with drug eruptions was 49,47 (15-80) years. The mean age of the male patients was 46,42 (15-78) years while of the female patients, 54,22 (17-80) years. 4. Regarding the distribution, drug eruptions were either of generalized type (13,04%) or of patchy type (17,39%) or were localized on face - scalp (21,73%), arms (34,78%), trunk (56,52%), buttocks (4,3%) and legs (30,43%). 5. The incriminating drugs of our study were: antibiotics (39,13%), non-steroidal anti-inflammatory agents (13,04%), chemotherapeutic agents (13,04%), anticonvulsants (8,6%), systemic corticosteroids (8,6%), antifungal agents (4,3%), anticoagulants (4,3%) heavy metals (4,3%) and allopourinol (4,3%). 6. The clinical patterns of drug eruptions seen in our study, were the following: maculopapular or morbilliform eruptions (17,39%), acneiform or pustular eruptions (13,04%), fixed drug eruption (13,04%), psoriasiform eruptions (8,6%), vasculitis (8,6%), urticaria (4,3%), lichenoid eruptions (4,3%), vesicular or bullous eruptions (4,3%), eczematous reactions (4,3%), purpura (4,3%), drug-induced alopecia (4,3%), Stevens-Johnson syndrome (4,3%) and toxic epidermal necrolysis (4,3%). 7. Histopathological examination of our study’s drug eruptions showed similar histologic findings to the skin diseases that they resemble clinically. Light microscopy histological features of each case were assessed and classified in relation with the degree of probability of drug eruptions’ histological diagnosis, into the following categories: a) definite (13,04%), b) probable (13,04%), c) possible (13,04%), d) diagnosis of skin disease with no findings compatible to drug aetiology (26,08%), and e) non-specific findings (34,78%).Τα συμπεράσματα τα οποία προέκυψαν από την μελέτη 25 ασθενών μας με εξανθήματα που θεωρήθηκαν φαρμακευτικής αιτιολογίας και εξετάσθηκαν με οπτικό μικροσκόπιο και οι 11 εξ΄αυτών με οπτικό και ηλεκτρονικό μικροσκόπιο, συνοψίζονται στα εξής: 1. Τα κλινικά κριτήρια δεν επαρκούν για τη διάγνωση των φαρμακευτικών εξανθημάτων γιατί ενώ βάσει αυτών επιλέχθηκαν 25 ασθενείς, μόνο στους 23 (ποσοστό 92,0%) πιστοποιήθηκε τελικά η διάγνωση του φαρμακευτικού εξανθήματος. 2. Η συχνότητα εμφάνισης των φαρμακευτικών εξανθημάτων δεν εξαρτάται από το φύλο, αφού από το σύνολο των 23 ασθενών μας με φαρμακευτικό εξάνθημα, οι 14 ήταν άνδρες (60,86%) και οι 9 θήλεις (39,13%), ευρήματα που δεν είναι σε συμφωνία με την πλειονότητα της βιβλιογραφίας. 3. Ο μέσος όρος της ηλικίας των ασθενών μας με φαρμακευτικό εξάνθημα ήταν 49,47 (15-80) έτη. Οι άρρενες ασθενείς είχαν μέσο όρο ηλικίας τα 46,42 (15-78) έτη ενώ τα θήλεα 54,22 (17-80) έτη. 4. Η νόσος είχε γενικευμένη μορφή (13,04%) ή διάσπαρτη μορφή (17,39%), ή ήταν δυνατό να εντοπίζεται στο πρόσωπο και το τριχωτό της κεφαλής (21,73%), στα άνω άκρα (34,78%), στον κορμό (56,52%), τους γλουτούς (4,3%) και τα κάτω άκρα (30,43%). 5. Τα φάρμακα που θεωρήθηκαν υπεύθυνα για την πρόκληση των φαρμακευτι-κών εξανθημάτων στην μελέτη μας ήταν τα αντιβιοτικά (39,13%), τα ανοσοκατασταλτικά (13,04%), τα μη-στεροειδή αντιφλεγμονώδη (13,04%), τα αντιεπιληπτικά (8,6%), τα συστηματικά κορτικο-ειδή (8,6%), τα αντιμυκητιασικά (4,3%), τα αντιπηκτικά (4,3%), τα σκευάσματα σιδήρου (4,3%) και η αλλοπουρινόλη (4,3%). 6. Οι κλινικές εικόνες με τις οποίες εκδηλώθηκαν τα φαρμακευτικά εξανθήματα των ασθενών μας ήταν: τα κηλιδοβλατιδώδη ή ιλαροειδή εξανθήματα (17,39%), τα ακμοειδή ή φλυκταινώδη εξανθήματα (13,04%), το σταθερό φαρμακευτικό εξάνθημα (13,04%), το ψωριασιόμορφο εξάνθημα (8,6%), η αγγειίτιδα (8,6%), η κνίδωση (4,3%), το λειχηνοειδές φαρμακευτικό εξάνθημα (4,3%), το φυσαλιδο-πομφολυγώδες εξάνθημα (4,3%), το εκζεματικό φαρμακευτικό εξάνθημα (4,3%), η πορφύρα (4,3%), η φαρμακογενής διάχυτη αλωπεκία (4,3%), το σύνδρομο Stevens-Johnson (4,3%), η ερυθροδερμία (4,3%) και η ΤΕΝ (4,3%)
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