6 research outputs found
The impact of preceding infections on the clinical presentation and prognosis of Guillain-Barré Syndrome: A focus on post-COVID-19 GBS
No full textThis paper aims at comparing the results of GBS patients with SARS-CoV-2 infection with those patients who have developed the condition due to other infections including Campylobacter and Zika virus. In all, 295 confirmed GBS cases following COVID-19 vaccination were evaluated and showed 93.2 % of higher hospitalisation and substantial respiratory involvement, suggesting that COVID-19 vaccinated GBS course is more severe than GBS with other infections. Although the GBS development in Campylobacter-associated cases is considered to reveal less severe symptoms and more favourable prognosis after IVIG or plasmapheresis application, only 62 percent of COVID-19-associated GBS patients demonstrated the improvement, and long-term comorbidity is more expressive. The study also emphasizes that early symptoms and its severity are the key components for establishing the prognosis of the disease; patients with higher initial symptom severity initially often experience longer stays in the hospital and statistically worse outcomes. Moreover, different immunity to pathogens, revealed by MAbs, are underlain by dissimilar prognosis depending on the cause of infection. Thus, these results emphasise the need for a highly tailored approach to clinical management of GBS patients that would involve attention to the infectious pathogen. More study is required to fine-tune medical approach and enhance people's well-being since pathogens change over the time. The findings of this scholarly work add to the current understanding of the diverse manifestations and characteristics of GBS and inform clinical practice regarding the post-infectious neurological sequelae of the disease more broadly
The Prognostic Value of Cardiac Troponin in Acute Ischemic Stroke Patients With Heart Failure: A Comparative Study Across Age Groups.
No full textHence, this research aims to establish the correlation between cardiac troponin and results in acute ischemic stroke (AIS) patients with heart failure. It examines 367 AIS patients stratified into 2 age groups: 65-74 years and ≥75 years. According to the findings, independent ambulation at admission or discharge signifies less severe strokes National Institutes of Health Stroke Scale. That is, the characteristics that are important for the stroke severity in patients of different ages are different: while the patients aged 75 and older, the important predictors are peripheral vascular disease and increased heart rate, the stroke severity in the younger age is predicted by smoking history and increased serum creatinine. Further, the article examines the value of troponin in a consecutive series of 1145 AIS patients and demonstrates that increased troponin is an independent predictor of in-hospital mortality. Mortality of the troponin-positive patients is significantly high with an odds ratio of 4.28. Moreover, the second trial on 200 AIS patients demonstrated that the cardiac troponin isoforms size is an independent predictor of major adverse cardiac events, odds ratio of 9.76. A study of 151,972 reaffirms the relationship between high troponin levels, increased stroke severity, and worse clinical prognosis. In conclusion, the current work fosters the significance of evaluating cardiac troponin in AIS patients with heart failure for enhanced mortality and adverse cardiovascular events\u27 risk estimation
Global trends and insights Into the Neurological Manifestations of Sjogren's Syndrome: a bibliometric review
No full textNeurological symptoms in Sjögren's syndrome (SS) present across a spectrum of severity, posing diagnostic and therapeutic challenges. This bibliometric review adopts a comprehensive approach to analyze the research landscape related to these symptoms. The data source utilized for this bibliometric review was the Web of Science Core Collection. The study selection encompassed English-language articles and reviews published between January 1, 2006, and June 30, 2023. Data extraction involved a systematic analysis of a total of 910 publications, which included 625 research articles and 285 reviews. The publication trends indicate a steady growth in research output, peaking with 122 papers in 2022. Geographic contributions primarily originate from the United States, followed by robust European contributions and increasing input from Asian countries, particularly China and Japan. Influential researchers such as Smith JM from Johns Hopkins University, Brown L from Harvard University, and Wang Q from Peking University have significantly shaped this field. Key institutions driving substantial publication volume and citation impact include Johns Hopkins University, Harvard University, and the University of Tokyo. Furthermore, journals such as Neurology, Journal of Autoimmunity, and Clinical Rheumatology play pivotal roles in disseminating advancements in SS-related neurological research. Future research priorities should focus on primary prevention, emphasizing the need for global cooperation and collaboration in neurological SS workup. There is a call for encouraging interdisciplinary, internationally focused investigative efforts specifically targeting SS neurologists. Key focus areas include potential preventive therapies aimed at significant neural dysfunctions (e.g., sensory neuropathy), mechanisms of microvascular dysfunction, and cognitive profiles/immunomodulation against autoantibodies. This analysis underscores the continued necessity for further research to optimize diagnosis and treatment in cases involving the complexities of neurological involvement with SS.https://www.cureus.com/articles/313678-global-trends-and-insights-into-the-neurological-manifestations-of-sjgrens-syndrome-a-bibliometric-review#!
