193 research outputs found
Supplemental Material, sj-docx-1-ptd-10.1177_08968608221091023 - Risk factors and outcomes of neonates with acute kidney injury needing peritoneal dialysis: Results from the prospective TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) study
No full textSupplemental Material, sj-docx-1-ptd-10.1177_08968608221091023 for Risk factors and outcomes of neonates with acute kidney injury needing peritoneal dialysis: Results from the prospective TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) study by Sidharth Kumar Sethi, Sanjay Wazir, Jagdish Sahoo, Gopal Agrawal, Naveen Bajaj, Naveen Parkash Gupta, Shishir Mirgunde, Binesh Balachandran, Kamran Afzal, Anubha Shrivastava, Jyoti Bagla, Sushma Krishnegowda, Ananth Konapur, Azmeri Sultana, Kritika Soni, Nikhil Nair, Divya Sharma, Prajit Khooblall, Avisha Pandey, Khalid Alhasan, Mignon McCulloch, Timothy Bunchman, Abhishek Tibrewal and Rupesh Raina in Peritoneal Dialysis International</p
Supplemental Material, sj-docx-2-ptd-10.1177_08968608221091023 - Risk factors and outcomes of neonates with acute kidney injury needing peritoneal dialysis: Results from the prospective TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) study
No full textSupplemental Material, sj-docx-2-ptd-10.1177_08968608221091023 for Risk factors and outcomes of neonates with acute kidney injury needing peritoneal dialysis: Results from the prospective TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) study by Sidharth Kumar Sethi, Sanjay Wazir, Jagdish Sahoo, Gopal Agrawal, Naveen Bajaj, Naveen Parkash Gupta, Shishir Mirgunde, Binesh Balachandran, Kamran Afzal, Anubha Shrivastava, Jyoti Bagla, Sushma Krishnegowda, Ananth Konapur, Azmeri Sultana, Kritika Soni, Nikhil Nair, Divya Sharma, Prajit Khooblall, Avisha Pandey, Khalid Alhasan, Mignon McCulloch, Timothy Bunchman, Abhishek Tibrewal and Rupesh Raina in Peritoneal Dialysis International</p
Electrochemomechanics in Mixed Ionic Electronic Conductors and solid oxide cells
Full text linkThis thesis presents a model for coupled electrochemomechanics in Mixed Ionic Electronic Conductors (MIEC). A continuum model is formulated to simulate the transport of ionic defects and the stress distribution in the conductor arising from the chemical expansion associated with the defects. First, a finite element formulation of the model is developed and validated with various analytical solutions and comparisons with experimental results. In the third chapter the coupled model is used along with an iterative scheme to simulate the transport characteristics in solid oxide cells with oxygen surface exchange and results are compared with experimental cell operation. The model is used to study the effect of oxygen surface exchange and the bulk diffusion of defects on the performance of solid oxide cell. In the fourth chapter, the transport of ionic defects is studied under spatially varying oxygen surface exchange in solid oxide cells due to the presence of metal current collector. Various defect transport mechanisms (boundary value problem setups) are proposed and studied to identify and explain the influence of metal current collector on oxygen exchange at the electrode film surface.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2022-08-01The student, Rupesh Kumar Mahendran, accepted the attached license on 2020-07-21 at 16:46.The student, Rupesh Kumar Mahendran, submitted this Thesis for approval on 2020-07-21 at 17:01.This Thesis was approved for publication on 2020-07-24 at 10:34.DSpace SAF Submission Ingestion Package generated from Vireo submission #15716 on 2020-10-02 at 15:34:04Made available in DSpace on 2020-10-07T22:44:46Z (GMT). No. of bitstreams: 3
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Previous issue date: 2020-07-24Embargo set by: Seth Robbins for item 116264
Lift date: 2022-10-07T22:44:53Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemAuthor requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Onl
Transition of Care from Pediatric to Adult Hemodialysis Units: A Systematic Review with Recommendations
No full textThe aims of this paper are to 1) critically evaluate the current evidence and experiences surrounding transitions of
care from pediatric to adult hemodialysis units and 2) make recommendations that can be implemented for such
transitions
Atypical Hemolytic-Uremic Syndrome: Genetic Basis, Clinical Manifestations, and a Multidisciplinary Approach to Management
No full textKeval Yerigeri,1 Saurav Kadatane,2 Kai Mongan,3 Olivia Boyer,4 Linda LG Burke,5 Sidharth Kumar Sethi,6 Christoph Licht,7 Rupesh Raina8 1Department of Internal Medicine-Pediatrics, Case Western Reserve University/The MetroHealth System, Cleveland, OH, USA; 2Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 3Northeast Ohio Medical University, Rootstown, OH, USA; 4Department of Pediatric Nephrology, Dialysis and Transplantation, Necker-Enfants Malades Hospital, MARHEA reference Center, Imagine Institute, Paris Cité University, Paris, France; 5aHUS Global Advocate with aHUS Alliance, Cape Elizabeth, ME, USA; 6Department of Pediatric Nephrology and Pediatric Renal Transplant Medicine, Kidney and Urology Institute, Medanta, The Medicity, Gurgaon, Haryana, India; 7Department of Paediatrics, Division of Nephrology, University of Toronto, Toronto, ON, Canada; 8Division of Pediatric Nephrology, Akron Children’s Hospital, Akron, OH, USACorrespondence: Rupesh Raina, Tel +1 216 401 7894, Email [email protected]: Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy (TMA) defined by the triad of hemolytic anemia, thrombocytopenia, and acute kidney injury. Microthrombi develop in the glomerular capillaries secondary to endothelial damage and exert shear stress on red blood cells, consume platelets, and contribute to renal dysfunction and failure. Per current understanding of pathophysiology, HUS is classified into infectious, secondary, and atypical disease. The most common etiology is infectious sequelae of Shiga toxin-producing Escherichia coli (STEC); other causative organisms include shigella and salmonella. Secondary HUS arises from cancer, chemotherapy, solid organ and hematopoietic stem cell transplant, pregnancy, or autoimmune disorders. Primary atypical hemolytic-uremic syndrome (aHUS) is associated with genetic mutations in complement and complement regulatory proteins. Under physiologic conditions, complement regulators keep the alternative complement system continuously active at low levels. In times of inflammation, mutations in complement-related proteins lead to uncontrolled complement activity. The hyperactive inflammatory state leads to glomerular endothelial damage, activation of the coagulation cascade, and TMA findings. Atypical hemolytic-uremic syndrome is a rare disorder with a prevalence of 2.21 to 9.4 per million people aged 20 years or younger; children between the ages of 0 and 4 are most affected. Multidisciplinary health care is necessary for timely management of its extra-renal manifestations. These include vascular disease of the heart, brain, and skin, pulmonary hypertension and hemorrhage, and pregnancy complications. Adequate screening is required to monitor for sequelae. First-line treatment is the monoclonal antibody eculizumab, but several organ systems may require specialized interventions and coordination of care with sub-specialists.Keywords: atypical hemolytic uremic syndrome, eculizumab, plasma exchange, complications, extra-renal manifestation
A Systematic Review of the Health-Related Quality of Life for Pediatric Patients with End-Stage Kidney Disease
No full textKidney failure, known as End Stage Kidney Disease (ESKD), is fatal unless medical interventions such as dialysis or kidney transplantation are implemented. Either of these interventions can involve significant changes in the lives of patients. There have been many health-related quality of life (HRQoL) studies suggesting the impact of kidney failure on physical and psychosocial development in children at home and school. However, systematic reviews on HRQoL are lacking in these children. This systematic review examines globally published literature on the health-related quality of life (HRQoL) among pediatric patients with ESKD receiving different treatment modalities. In addition, this review serves to provide recommendations for managing pediatric patients undergoing dialysis or kidney transplants
Artificial intelligence and pediatric acute kidney injury: a mini-review and white paper
Full text linkAcute kidney injury (AKI) in pediatric and neonatal populations poses significant diagnostic and management challenges, with delayed detection contributing to long-term complications such as hypertension and chronic kidney disease. Recent advancements in artificial intelligence (AI) offer new avenues for early detection, risk stratification, and personalized care. This paper explores the application of AI models, including supervised and unsupervised machine learning, in predicting AKI, improving clinical decision-making, and identifying subphenotypes that respond differently to interventions. It discusses the integration of AI with existing risk scores and biomarkers to enhance predictive accuracy and its potential to revolutionize pediatric nephrology. However, barriers such as data quality, algorithmic bias, and the need for transparent and ethical implementation are critical considerations. Future directions emphasize incorporating biomarkers, expanding external validation, and ensuring equitable access to optimize outcomes in pediatric AKI care
A Systematic Review of the Extrarenal Manifestations of atypical Hemolytic Uremic Syndrome
No full textAtypical Hemolytic Uremic Syndrome (aHUS) is a variant of thrombotic microangiopathies (TMA), characterized by aberrant activation of the alternative complement immune system. This disease is rare and involves a complicated diagnosis resulting from clinical presentations such as microthrombi in the kidneys, thrombocytopenia, hemolytic anemia, and renal dysfunction. Extra-renal symptoms are found in nearly 20% of all patients with aHUS, and we seek to characterize the demographic, clinical, and genetic outcomes of this population to provide clinical recommendations and guidelines for diagnosis and treatment
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