911 research outputs found
Structural, Hirshfeld surface and in vitro cytotoxicity evaluation of five new N-aryl-N’-alkoxycarbonyl thiocarbamide derivatives.
No full textFive new compounds, N-(2, 4-dichlorophenyl)-N’-(methoxycarbonyl) thiocarbamide (1), N-(2, 4-
dichlorophenyl)-N’-(ethoxycarbonyl) thiocarbamide (2), N-(2, 4-dichlorophenyl)-N’-(2, 2, 2-trichloroethoxycarbonyl)
thiocarbamide (3), N-(2,4-dichlrophenyl)-N’-(pentoxycarbonyl) thiocarbamide (4)
and N-(4-nitrophenyl)-N’-(pentoxycarbonyl) thiocarbamide (5), have been synthesized by the reaction
of various alkoxy chloroformates with 2, 4-dichloroaniline/4-nitroaniline.The molecular structures
of the compounds were elucidated by using spectroscopic methods (FT-IR, 1H and 13C NMR)
and single-crystal X-ray structure analysis of compounds 2 and 5. Antiperiplanar orientation of
C1⁄4O and C1⁄4S group across C–N bonds of thiocarbamide core may be due to the presence of
intramolecular (N–HO–C) hydrogen bond in the crystal structure of both the compounds. The
presence of intermolecular interactions (C–HS, C–HO and N–HS) in the molecular structure of
the compounds has been studied in detail using Hirshfeld surfaces and their associated twodimensional
fingerprint plots. In vitro cytotoxicity screening of the synthesized compounds evaluated
on a panel of seven human cancer cell lines (cervical carcinoma (2008, C13), colorectal
(HT29 and HCT116) and ovarian carcinoma (A2780, A2780/CP and IGROV-1)) demonstrated significant
inhibitory properties
Synthesis, characterization, Hirshfeld surface, cytotoxicity, DNA damage and cell cycle arrest studies of N, N-diphenyl-N'-(biphenyl-4- carbonyl/4-chlorobenzoyl) thiocarbamides
No full textThe condensation reaction of biphenyl-4-carbonyl isothiocyanate/4-chlorobenzoyl isothiocyanate with
diphenylamine yielded two new compounds; N-diphenyl-N'-(biphenyl-4-carbonyl) thiocarbamide (1)
and N, N-diphenyl-N'-(4-chlorobenzoyl) thiocarbamide (2). Structure of the compounds were determined
by analytical, spectroscopic (UVeVisible, FTIR, 1H, & 13C NMR), powder and single-crystal X-ray
diffraction methods. Hirshfeld surface analysis and their associated two dimensional fingerprint plots of
compounds were used as theoretical approach to assess driving force for crystal structure formation via
the intermolecular interactions in their crystal lattices. The compounds were screened for their in vitro
cytotoxicity activity against a panel of five human cancer cell lines namely; cervical (2008 and C13*) and
ovarian carcinoma (A2780, A2780/CP and IGROV-1). Both the compounds exhibited promising activity
against cervical and IGROV-1 cancer cells whereas for the other two cell lines appreciable activities were
observed. The cell cycle arrest at G0/G1 phase is supported by the DNA damage and apoptosis studies of
the compounds against 2008, C13* and IGROV-1 cell line
Dabrafenib-Panobinostat Salt: Improving Dissolution Rate and Inhibition of BRAF Melanoma Cells
No full textCocrystallization of the drug−drug salt-cocrystal of the histone
deacetylase inhibitor (HDACi) panobinostat (PAN) and b-rapidly accelerated
fibrosarcoma (BRAF) inhibitor dabrafenib (DBF) afforded single crystals of a
two-drug salt stabilized by N+−H···O and N+−H···N− hydrogen bonds
between the ionized panobinostat ammonium donor and dabrafenib
sulfonamide anion acceptor in a 12-member ring motif. A faster dissolution
rate for both drugs was achieved through the salt combination compared to the
individual drugs in an aqueous acidic medium. The dissolution rate exhibited a
peak concentration (Cmax) of approximately 310 mg cm−2 min−1 for PAN and
240 mg cm−2 min−1 for DBF at a Tmax of less than 20 min under gastric pH 1.2
(0.1 N HCl) compared to the pure drug dissolution values of 10 and 80 mg
cm−2 min−1, respectively. The novel and fast-dissolving salt DBF−·PAN+ was
analyzed in BRAFV600E melanoma cells Sk-Mel28. DBF−·PAN+ reduced the
dose−response from micromolar to nanomolar concentrations and lowered IC50 (21.9 ± 7.2 nM) by half compared to PAN alone
(45.3 ± 12.0 nM). The enhanced dissolution and lower survival rate of melanoma cells show the potential of novel DBF−·PAN+ salt in clinical evaluation
Synthesis, characterisation, Hirshfeld surface and in vitro cytotoxicity evaluation of new N-aryl-N0-Alkoxycarbonyl thiocarbamide derivatives.
No full textFour new compounds N-(4-nitrophenyl)-N’-(isobutoxycarbonyl) thiocarbamide (1), N-(2, 4-nitrophenyl)- N’-(isobutoxycarbonyl) thiocarbamide (2), N-(4-nitrophenyl)-N’-(ethoxycarbonyl) thiocarbamide (3) and N-(2-Chloro- 4-nitrophenyl)-N’-(ethoxycarbonyl) thiocarbamide (4) were prepared and their structures confirmed by using various spectroscopic (FT-IR, UVeVisible, 1H and 13C NMR) and single crystal X-ray studies of 1 and 3. The presence of intramolecular (NeH/O]C) hydrogen bond in the crystal structure of both the compounds causes planarity of carbonyl thiocarbamide unit and trans orientation of C]O and C]S group. The intermolecular contacts (CeH/S, CeH/O and NeH/S) present in crystal structures have been examined by Hirshfeld surface analysis and their associated 2D fingerprint plots. All the compounds were assessed for their in vitro cytotoxic properties against a panel of seven human cancer cells such as cervical carcinoma (2008, C13*), colorectal (HT29 and HCT116) and ovarian carcinoma (A2780, A2780/CP and IGROV-1). Among them, compounds 2 and 4 exhibited better activity than 1 and 3 against all the cell lines tested
Plurality, Identity, Democracy, Globalization... A conversation with Sunil Khilnani
No full textabstract
Rossella Ciocca interviews Sunil Khilnani author of the much appraised The Idea of India: one of the best non-fictional introductions to the complexities of politics in contemporary India. The strengths and weaknesses of present-day uneven modernity are discussed around a few strategic topics. First of all plurality, which in its linguistic, cultural, religious, ethnic variety has been vindicated since Independence as a foundational value, is seen as the quintessential resource for achosen practice of syncretism but also in danger of becoming the very source of fragmentation and implosion in a country increasingly maimed by fundamentalism and fanaticism. Democracy is then interrogated between the comfortable perspective of the firmly established and normally operating mechanisms of democratic routine, on the one hand, and the flawsof a still dramatically unjust system of distribution of rights and opportunities, on the other. Identity politics is in turn analysed both in its positive action of mobilizing society around the problem of social upgrading and in its unwelcome side effects of increasing practices of rigid and restricted classification fomenting division and violent sectarianism. In the end Indian growing cultural appeal upon the globalized scene is questioned in its complex relationship with the country’s quest for a role of protagonist in political as well as economic affairs upon a new multilateral international stage
Bollywood cinema: A critical genealogy
No full text"Bollywood" has finally made it to the Oxford English Dictionary. The 2005 edition defines it as: "a name for the Indian popular film industry, based in Bombay. Origin 1970s. Blend of Bombay and Hollywood." The incorporation of the word in the OED acknowledges the strength of a film industry which, with the coming of sound in 1931, has produced some 9,000 films. (This must not be confused with the output of Indian cinema generally, which would be four times more). What is less evident from the OED definition is the way in which the word has acquired its current meaning and has displaced its earlier descriptors (Bombay Cinema, Indian Popular Cinema, Hindi Cinema), functioning, perhaps even horrifyingly, as an "empty signifier" (Prasad) that may be variously used for a reading of popular Indian cinema. The triumph of the term (over the others) is nothing less than spectacular and indicates, furthermore, the growing global sweep of this cinema not just as cinema qua cinema but as cinema qua social effects and national cultural coding. Although Indian film producers in particular, and pockets of Indian spectators generally, continue to feel uneasy with it (the vernacular press came around to using "Bollywood" only reluctantly), its ascendancy has been such that Bombay Dreams (the Andrew Lloyd Weber musical) and the homegrown Merchants of Bollywood both become signifiers of a cultural logic which transcends cinema and is a global marker of Indian modernity. As the Melbourne (March 2006) closing ceremony of the Commonwealth Games showed, Bollywood will be the cultural practice through which Indian national culture will be projected when the games are held in Delhi in 2010. International games (the Olympics, World Cup Soccer, Asian Games, Commonwealth Games, and so on) are often expressions of a nation's own emerging modernity. For India that modernity, in the realm of culture, is increasingly being interpellated by Bollywood
The Fight Against Government Secrecy
No full textLocal journalist and author Miranda Spivack has a new book out, Backroom Deals in Our Backyard: How Government Secrecy Harms Our Communities and the Local Heroes Fighting Back. Sunil Dasgupta talks to Spivack about the book, why transparency has been a persistent problem in government, and how the public can fight back. Music by Washington art-pop rock band Catscan!https://open.spotify.com/episode/1UrBdTiUInvcV3xXgjK1R
The Long and Continuing Fight to Save Public Education
No full textEpisode · I Hate Politics Podcast · With school boards around the country under attack from right-wing extremists, a veteran Silver-Spring based education reporter and author, Karen Chenoweth, has founded a resource to help school board candidates and school board members fight back. Sunil Dasgupta talks to Chenoweth about her website democracy-education.org and her mission. Music from Finster.https://open.spotify.com/episode/7gUiArNXgofhVTx1vweJE
On Barthes’ biography
No full textThis article presents an interview with Tiphaine Samoyault, author of Roland Barthes, Biographie (Éditions du Seuil, 2015). There is always a difficulty in approaching the biography of Roland Barthes, who famously gave us the thesis of the ‘death of the author’. Nonetheless, Samoyault’s lengthy study can be considered the closest thing to an ‘official’ biography. Unlike other biographers, she was given access to and granted permission to cite from a wide range of private papers and materials. This inside view has not stopped her from detailing some of the more sensitive sides of Barthes’ life, and importantly she has been able to reassess aspects of his writings and relationship to other key thinkers of the time and the wider politics. As part of the interview, various extracts from the biography are woven into the dialogue, allowing those unfamiliar with it to gain more direct access to the book itself
What AMZN HQ2 Search Tells Us About Government Transparency
No full textThere is a long tradition in political philosophy where democracy and transparency are equated. A new article in the Policy Studies Journal, by UMBC colleagues UMBC’s Eric Stokan, Ian Anson, University of Texas Austin’s Nathan Jensen studied the impact of government transparency on Amazon’s search for its second headquarters to find surprising conclusions: https://doi.org/10.1111/psj.70016 . Sunil Dasgupta talks with lead author Eric Stokan. Music by Frederick, MD,- based country-folk singer-songwriter Susanna Laird.https://open.spotify.com/episode/2bNPVzoK9pPWHkFYzINHU
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