2,172 research outputs found
Italia-America Latina: dal post-Guerra fredda alle Conferenze Italia-ALC
Get PDFIl presente articolo indaga le relazioni italo-latinoamericane nella congiuntura
compresa tra la fine del conflitto bipolare e, grosso modo, il primo quindicennio del
nuovo millennio, quando le Conferenze tra l’Italia e l’America Latina e i Caraibi (Italia-
ALC), diventano uno dei principali strumenti utilizzati dall’Italia nella sua interlocuzione
con i paesi latinoamericani
Qualche ombra sull'effettività della tutela giurisdizionale avverso le leggi provvedimento
No full textIl lavoro si interroga su talune acquisizioni della giurisprudenza costituzionale in materia di leggi provvedimento, particolarmente alla luce della circostanza che il processo amministrativo, quale sede naturale del controllo di legittimità sull’azione amministrativa, ha subito in questi anni profonde trasformazioni (l’ultima a seguito dell’entrata in vigore del Codice del processo amministrativo), evolvendosi da sindacato sulla legittimità del singolo atto a sindacato sul rapporto tra amministrazione e cittadino che ha originato la controversia. Sicché, se appare un’affermazione in linea di principio rispondente al vero che il processo amministrativo della fine degli anni ’50 offriva grosso modo le stesse garanzie della giurisdizione costituzionale, l’accettazione di tale postulato sembra richiedere oggi quanto meno una verifica, anche alla luce della mole del contenzioso, non soltanto costituzionale, che negli ultimi anni ha investito l’attività amministrativa in forma di legge
Defective mRNA levels are responsible for a beta-thalassemia phenotype associated with Hb Federico II, a novel haemoglobin variant (beta 106 (G8) Leu->Val).
No full textThis study provides the first experimental evidence that a single nucleotide mutation within the coding region of the β-globin gene affects mRNA expression levels and causes a β-thalassemic defect. Furthermore, our data suggest that other regions besides the 3′UTR, whose role in constitutively regulation of this mechanism has been recently identified, may contribute to the stabilization of β-globin mRNA and could, therefore, help to characterize the molecular basis of thalassemic hemoglobinopathies
Prenatal diagnosis of haemoglobinopathies: our experience of 523 cases
No full textAbstract
Background: We performed counselling for prenatal diagnosis (PD) of haemoglobinopathies in 372 couples. Thirty-four out of 372 (9.1%) did not undergo PD: six due to spontaneous abortion; nine because it was too difficult to make a decision if PD was positive; 18 because counselling excluded the carrier status of one or both parents; and one because parental mutations were mild.
Methods: Eleven out of 338 (3.3%) couples underwent PD because they had a thalassaemic child; 106 (31.4%) were found to be at high risk during pre-conceptional screening; 221 (65.4%) because of familiarity. Of 523 PDs in 486 (92.9%), including six dichorionic twin pregnancies, PD was performed on DNA from chorionic villi (CV), and in 37 from amniocytes (7.1%). In 1/523 cases, PD was not completed because DNA from CV was not sufficient; in two cases single tandem repeat analysis revealed maternal contamination of foetal DNA; in 7/522 (1.3%) cases PD revealed non-paternity. In 435/522 (83.3%) cases, PD was performed using reverse dot-blot and ARMS; 34/522 (6.5%) required sequencing. In 53/522 (10.2%) cases it was necessary to test globin loci for large rearrangements.
Results: One hundred and twenty out of 522 (23.0%) PDs revealed an affected foetus. In all but two cases the couple interrupted pregnancy. In the six twin pregnancies PD revealed a normal and a carrier foetus (two cases), carrier status in both foetuses (two cases) and a carrier and an affected foetus (two cases). In these latter cases the couple planned selective interruption.
Conclusions: Our PD procedure is successful and reliable, and is useful in high-risk areas characterised by molecular heterogeneity
Identification of molecular interactors of the Cold Shock Domain Protein A (CSDA), a repressor factor of gamma globin gene expression.
No full textMir-137 targets the 3′ untranslated region of msh2: Potential implications in lynch syndrome-related colorectal cancer
No full textImpaired beta-globin mRNA stability is responsible of a beta-thalassemic phenotype associated with Hb Federico II [beta-106 (G8) Leu’Val)].
No full textPostictal serum nucleotidases activities in patients with epilepsy.
No full textAdenosine, a potent anticonvulsant, can be produced in the body by the hydrolysis of adenine nucleotides through the action of ecto- or soluble nucleotidases. Changes in nucleotide hydrolysis occur after pentylenetetrazol-induced epileptic events. We evaluated serum ATP, ADP and AMP hydrolysis rates and soluble nucleotide phosphodiesterase (PDEase) activity at 5, 10, 15, 30 and 60 min, and 12h following an epileptic event. Fifteen patients (seven female, eight male; mean age 15.5 years) were included in the study. The type of seizure was generalized in four patients and was localization related in the remaining 11. There were no differences in adenine nucleotide hydrolysis rates between patients and healthy subjects in the interictal stage. In comparison with controls, ATP, ADP and AMP hydrolysis rates were significantly increased at 5 min (53+/-1.4%, 79.2+/-2.8% and 37.0+/-2.6%, respectively) and up to 30 min following the epileptic event. In contrast to ADP and AMP, ATP hydrolysis remained significantly increased at 60 min (71.4+/-1.6%), returning to the basal level after 12h. Serum PDEase activity was also significantly higher in the patients than in healthy subjects, peaking at 15 min (61+/-2.9%) and remaining significantly increased up to 60 min (4.6+/-1.2%) following the epileptic episode. Globally, the variations in the postictal serum ADP hydrolysis rate almost overlapped those of AMP hydrolysis, whereas changes in the ATP hydrolysis rate overlapped those of PDEase activity. The clinical significance of this elevation in postictal soluble serum nucleotidase activity remains to be clarified. However, it is possible to hypothesize that the higher nucleotidase activity might play a role in the modulation of epileptic event
Multi-agent control architecture for large scale multi-robot system
No full textAs research progresses in distributed robotic systems, more and more aspects of multi-robot systems are being explored. This dissertation focuses on multi-robot control systems and provides the model of an agent-based control architecture following the research that is ongoing in the field of distributed mobile robot systems. In this work, the agent technology is proposed as a possible approach to the design of multi-robot systems. Autonomous agents, or sometimes called intelligent agents, can effectively combine all the advantages of distributed systems with advanced robot control support and artificial intelligence techniques. The coordination of the multi-robot system is based on agent interaction and negotiation, and a communication infrastructure based on open web standards is provided. This paper is the result of the work done within the ROBOSWARM European Project
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