101,783 research outputs found
Cuerpos hinchados
No full textConferència a càrrec de l'arquitecte Smiljan Radic´per Projectes I-II T, assignatura coordinada per Pere Joan Ravetllat, Departament de Projectes Arquitectònics ETSAB | UPC.Conferència a càrrec de l'arquitecte Smiljan Radic´ per Projectes I-II T, assignatura coordinada per Pere Joan Ravetllat, Departament de Projectes Arquitectònics ETSAB | UPC
Cuerpos hinchados
No full textConferència a càrrec de l'arquitecte Smiljan Radic´per Projectes I-II T, assignatura coordinada per Pere Joan Ravetllat, Departament de Projectes Arquitectònics ETSAB | UPC.Conferència a càrrec de l'arquitecte Smiljan Radic´ per Projectes I-II T, assignatura coordinada per Pere Joan Ravetllat, Departament de Projectes Arquitectònics ETSAB | UPC
SENIEUR status of the originating cell donor negates certain ‘anti-immunosenescence’ effects of ebselen and N-acetyl cysteine in human T cell clone cultures
No full textBackground: Damage to T cells of the immune system by reactive oxygen species may result in altered cell function or cell death and thereby potentially impact upon the efficacy of a subsequent immune response. Here, we assess the impact of the antioxidants Ebselen and N-acetyl cysteine on a range of biological markers in human T cells derived from a SENIEUR status donor. In addition, the impact of these antioxidants on different MAP kinase pathways in T cells from donors of different ages was also examined. Methods: T cell clones were derived from healthy 26, 45 and SENIEUR status 80 year old people and the impact of titrated concentrations of Ebselen or N-acetyl cysteine on their proliferation and in vitro lifespan, GSH:GSSG ratio as well as levels of oxidative DNA damage and on MAP kinase signaling pathways was examined
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Are Customers Always Right? Fees to Protect Firms from Customer Opportunistic Behavior
No full textConsumer advocates criticize the increase use of fees charged on top of the prices for the core products as ploys to empty customer pockets. Our research shows that this criticism is not always justified, and that some fees (such as cancellation fees, restocking fees, nonrefundable shipping and handling fees, and cover charges by restaurants) are necessary to protect firms from opportunistic consumers, and also to protect well-behaved consumers from paying higher prices
Could higher fees lead to lower prices?
No full textPurpose – Supplementary fees such as restocking fees, nonrefundable shipping and handling fees, and cancellation fees have become prevalent in the USA, and customers as well as the popular media have raised serious concerns about them. This paper aims to test whether such fees could benefit consumers because they lead to lower prices.
Design/methodology/approach – Transaction data that include prices and fees were collected from different service providers, including hotels, airlines, online retailers, and restaurants. The data were collected from different countries at different points in time. Cross-sectional and panel data sets were used to test the relationship between fees and prices.
Findings – The empirical results indicate that on average higher fees lead to lower prices for the majority of customers who do not abuse customer-friendly service policies. These findings are valid for different service industries in different countries even after controlling for unobserved heterogeneity using panel econometric models.
Originality/value – The results are consistent with the hypothesis that special fees are used to limit the abuse of customer-friendly service policies, thus helping service providers to offer lower prices to the majority of customers who do not abuse these policies
First epigravettian ceramic figurines from Europe (Vela Spila, Croatia)
No full textRecent finds of 36 ceramic artifacts from the archaeological site of Vela Spila, Croatia, offer the first evidence of ceramic figurative art in late Upper Palaeolithic Europe, c. 17,500–15,000 years before present (BP). The size and diversity of this artistic ceramic assemblage indicate the emergence of a social tradition, rather than more ephemeral experimentation with a new material. Vela Spila ceramics offer compelling technological and stylistic comparisons with the only other evidence of a developed Palaeolithic ceramic tradition found at the sites of Pavlov I and Dolní V?stonice I, in the Czech Republic, c. 31,000–27,000 cal BP. Because of the 10,000-year gap between the two assemblages, the Vela Spila ceramics are interpreted as evidence of an independent invention of this technology. Consequently, these artifacts provide evidence of a new social context in which ceramics developed and were used to make art in the Upper Palaeolithic
Changes in foraging behaviour suggest competition between wild and domestic ungulates: Guanaco and domestic sheep in southern Patagonia
No full textPrevious attempts to address the presence of interspecific competition between domestic livestock and wild ungulates have focused largely on habitat or dietary overlaps. Although overlaps in habitat or diet create opportunities for competition to occur between species, competition only results from such overlap if it affects one or both species negatively. Less attention has been afforded to possible behavioural modifications induced in wildlife by competition with domestic livestock. Here, we investigated the effects of the presence of livestock on feeding behaviour of guanaco (Lama guanicoe) in southern Patagonia, using focal sampling of individuals during foraging bouts, with instantaneous scan samples to estimate group behavioural budgets. We recorded guanaco bite and step rates, used as proxies of foraging intake and selectivity, from four different study sites over eight consecutive seasons. We also estimated sheep and guanaco densities per site, along with vegetation biomass availability. As in other ungulates, bite rates of guanaco appear to be highly flexible and generally increased with vegetation biomass availability. However, as sheep densities and thus additional grazing pressure increased, guanaco foraging strategy compensated by increasing bite rates when foraging vegetation was scarce, indicating further likelihood of competition. Additionally, scan samples indicated that the probability of guanaco feeding occurring at any one time was higher in areas shared with domestic sheep compared to national parks, suggesting guanaco have to focus more on feeding than other behaviours when sheep are present
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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