33 research outputs found

    Novel mutation identified in severe early-onset tumor necrosis factor receptor-associated periodic syndrome: a case report

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    Abstract Background Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS) is the second most common heritable autoinflammatory disease, typically presenting in pre-school aged children with fever episodes lasting 1–3 weeks. Systemic symptoms can include rash, myalgia, ocular inflammation, and serositis. Case presentation Here we report an unusual presentation of TRAPS in a 7 month old girl who presented with only persistent fever. She was initially diagnosed with incomplete Kawasaki Disease and received IVIG and infliximab; however, her fevers quickly recurred. Subsequent testing revealed a urinary tract infection, but she did not improve despite appropriate therapy. As fever continued, she developed significant abdominal distension with imaging concerning for appendicitis, followed by hyperthermia and hemodynamic instability. Given her protracted clinical course and maternal history of a poorly defined inflammatory condition, an autoinflammatory disease was considered. Therapy with anakinra was initiated, resulting in rapid resolution of fever and normalization of inflammatory markers. She was found to have a previously unreported mutation, Thr90Pro, in the TNFRSF1A gene associated with TRAPS. This novel mutation was also confirmed in the patient’s mother and maternal uncle. Conclusions This report reviews a severe case of TRAPS in infancy associated with a novel mutation, Thr90Pro, in the TNFRSF1A gene, and emphasizes that autoinflammatory disease should be considered in the differential of infants with fever of unknown origin

    Electrolytic surface hardening of steel,castiron and aluminium-bronze

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    Electrolytic hardening process w as developed in USSR in the 1950s. The process w as developed but w as not com m ercially exploited. There is no evidence of w ork done on this process in India. The author has done this originalw ork applied to different m aterials like steel, castiron and alum inum -bronze.This paper gives details ofm icrostructuraltransform ations along w ith hardness value achieved. There is vitalscope for this process to becom e viable for surfacehardening and selective hardening ofsm allcom ponents

    Implementing the market approach to enterprise support - an evaluation of ten matching grant schemes

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    Developing viable new business is critical to recovery, and long-term growth, especially in transition economies. There has been a long history of public support of enterprise development, starting with centralized state agency initiatives, but moving more recently to decentralized instruments for development of the business services market. The window of time during which the benefits of intervention are likely to be greatest: when a market is in its infancy, and its development is constrained by uncertainty, and lack of information. Interventions for enterprise support should be demand-responsive, and flexibly organized. In some circumstances, centralized assistance may still be effective, but it is generally better to use competitive private service providers responding to enterprises'changing needs. The main task is to stimulate the private services sector, improving its capacity to respond to the demands of new, and expanding private enterprises. Support for enterprises has tended to be either free, or heavily subsidized. But such subsidies can be justified only if interventions efficiently supply goods. Providing technical, and management know-how can be a public good if it generates externalities- if, for example, know-how benefits can be disseminated at proportionately low additional cost. Any subsidy for an intervention should be temporary, and should be phased out when the main objective of intervention is achieved - that is, when the market takes off. Grants should generally be for know-how, not for equipment. There may be a case for unbundling the know-how component of loans (including feasibility studies, and follow-up expert services) for grant funding. A package combining loans and grants - through a single financial institution, or through separate institutions - may work provided safeguards can be put in place to prevent perverse use of grants. The matching grant model, which is used increasingly in the World Bank, and elsewhere, is one solution - but it must be justified, and carefully designed. After evaluating ten matching grant funds, the author concludes that performance is mixed. Best practice models are needed. Ensuring economic benefits requires proactive management, with clear objectives of market facilitation ("making a market"). And it requires a balance between rapid grant approval procedures, and careful selection of services for grants.Economic Theory&Research,Decentralization,Enterprise Development&Reform,Environmental Economics&Policies,Banks&Banking Reform,Health Economics&Finance,Banks&Banking Reform,Economic Theory&Research,Environmental Economics&Policies,ICT Policy and Strategies

    Fundamentals of heat transfer and thermal-mechanical control for improved atomic force microscopy

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    This dissertation presents novel atomic force microscope (AFM) cantilevers and cantilever technology that improve the measurement rate and precision of AFM. AFM cantilevers with integrated heater-thermometers can generate and sense heat flows to measure and manipulate matter at the nanometer scale. These heated cantilevers have been used for local measurements of material properties, tip-based nanomanufacturing, high-density data storage, and thermal topography imaging. This work focuses on thermal topography imaging wherein the cantilever measures the surface topography by tracking changes in the cantilever heat flow. This work shows the experimental and numerical investigation of cantilever heat transfer to substrates. The investigations show that the cantilever measures the topography height regardless of the substrate material properties. The lateral heat flow from the cantilever varies with the topography dimensions and causes the thermal topography to differ from the actual substrate topography. Insights from these investigations reveal a technique that corrects the thermal topography by eliminating most of the lateral heat flow from the cantilever. Arrays of cantilevers can significantly improve the measurement area and speed of AFM but array technology has been mostly inaccessible due to the need for specialized hardware. This dissertation reports the scalable integration of an array of 5 heated cantilevers into a commercial AFM using simple hardware and software. Cantilever temperatures are controlled in closed-loop feedback with 2 ˚C accuracy and 0.1 ˚C precision using analog circuitry rated at 1 MHz bandwidth. Analog cantilever temperature control is autonomous, inexpensive, scalable, and fast compared to conventional software implementations. The cantilever array performs parallel AFM imaging of a 550 µm × 90 µm area at 1.1 mm/sec with 0.6 nm vertical resolution and at 4.0 mm/sec with 44 nm wide pixels. The measurement rate was improved by more than 2 orders of magnitude compared to conventional AFM with a single cantilever. To demonstrate the ability to manufacture and repair nanostructures, the array performs multiple iterations of parallel nanolithography and topography imaging. Heated cantilevers are limited in their ability to precisely measure and control tip-sample forces due to parasitic resonances introduced by conventional piezoelectric actuators. This dissertation presents the development of two heated cantilevers designed for electromagnetic Lorentz force actuation. Electrical current passing through a U-shaped cantilever in the presence of a magnetic field induces a Lorentz force on the cantilever free end, resulting in cantilever actuation. These Lorentz-thermal cantilevers generate up to 7X larger Lorentz force and 2X larger oscillation amplitude compared to the state-of-art heated cantilevers. When used for thermal topography imaging, the Lorentz-thermal cantilevers can measure topography with vertical resolution of 0.2 nm.Item withdrawn by Laura Spradlin ([email protected]) on 2014-07-08T16:03:58Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Somnath_Suhas.pdf: 23151691 bytes, checksum: 92eb09ca09f7764576748141aafe6fd0 (MD5) Somnath_Suhas.docx: 25448946 bytes, checksum: 988a485cc465ea17773ce5e4ba18a515 (MD5)Made available in DSpace on 2014-09-16T17:12:04Z (GMT). No. of bitstreams: 3 Suhas_Somnath.pdf: 23151720 bytes, checksum: 8dae2dde7812f82a21a0fb585e14b21f (MD5) Somnath_Suhas.docx: 25453135 bytes, checksum: c7b43defb5250f8c32579a3543ebbb4c (MD5) license.txt: 4063 bytes, checksum: 0296f56e0d9df3da804380a06c5dd8d2 (MD5)Embargo set by: Seth Robbins for item 50469 Lift date: 2016-09-16T17:13:01Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 50469 on 2016-09-22T20:59:05Z

    Factors influencing Beall degermination of corn for dry milling

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    Pilot scale corn dry milling experiments were conducted to compare the throughput and the product yields obtained from the most widely reported procedure in scientific literature, 3-stage tempering, with those obtained from the most commonly commercially practiced procedure, 1-stage tempering. For certain conditions of temper duration and tail gate weight distance (tail gate loading), both procedures produced statistically similar results.Based upon these results, further experiments were conducted to examine the factors influencing the optimum tempering for dry milling. Central composite design was used to study the effects of temper duration and the operating parameters of temperature (corn and water), moisture (initial corn and temper), and the Beall degerminator controls (rotor position and weight distance) on the throughput and product yields. A single set of conditions that would maximize the throughput and the yields of the prime products was not found. The water temperature had a stronger effect than the corn temperature on most of the product yields for shorter temper durations, while the inverse was true for longer temper durations. The yield of flaking grits increased with an increase in the initial corn moisture, though the storage of corn at high initial moisture may result in corn spoilage. The throughput was more dependent upon the rotor position than the tail gate weight distance at higher rotor positions (closed position), while the opposite was true at lower rotor positions (open position).The effects of blocking certain sections of the degerminator casing and placing three different sized screens on the conical cage were also studied. Blocking section #3 alone (control condition) or together with any of the other sections, decreased the throughput and increased the flaking grits yield. Significantly higher flaking grit yield was also observed when the screen size was increased from 0.0056 (14/64 in) to 0.006 m (16/64 in) although the tail stock percentage was significantly reduced by 7% points when the screen size was increased.Experiments were also conducted to study the effect of using steam for tempering corn at two different initial corn temperatures (5 and 30\sp\circC). When steam and water were used together, the flaking grits yield from the corn at lower temperature (5\sp\circC) showed a significant improvement, though at the expense of throughput. The milling action of the Beall degerminator and the horizontal drum degerminator were also compared. Poor correlations were observed for the yields of similar sized products from the two degerminators, however, the Beall degenninator produced higher yields of prime products.All the experiments conducted in this study revealed inherent trade-offs in the recovery of the throughput and yields of prime products. The results clearly indicate that the selection of the levels and combinations of various operating variables depends on the overall milling objectives, since an increase in the yield of a prime product is often achieved at the expense of another.Made available in DSpace on 2011-05-07T13:14:04Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9712375.pdf: 11526176 bytes, checksum: e17d0b811d819ded19ca0c7191760cb7 (MD5) Previous issue date: 1996Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding ([email protected]) on 2011-05-07T14:52:04Z Item is restricted indefinitely.Restriction data tranferred 2014-07-01T11:23:56-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permissionETDs are only available to UIUC Users without author permissionU of I Onl

    Rent-sharing, hold-up, and manufacturing wages in Cote d'Ivoire

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    Labor costs in Francophone Africa are considered high by the standards of low-income countries, at least in the formal sector. Are they a brake on industrialization, or the result of successful enterprise development? Are they imposed on firms by powerful unions, or government regulations, or a by-product of good firm performance? The authors empirically analyze what determines manufacturing wages in Cote d'Ivoire, using an unbalanced panel of individual wages that allows them to control for observable firm-specific effects. They test the rent-sharing, and hold-up theories of wage determination, as well as some aspects of efficiency-wage theories. Their results lean in favor of both rent-sharing, and hold-up, suggesting that workers have some bargaining power, and that in Cote d'Ivoire workers can force renegotiation of labor contracts, in response to new investments.Economic Theory&Research,Public Health Promotion,Health Monitoring&Evaluation,Labor Policies,Environmental Economics&Policies,Economic Theory&Research,Environmental Economics&Policies,Health Monitoring&Evaluation,Health Economics&Finance,Statistical&Mathematical Sciences

    Effect of high pressure processing on selected physicochemical and functional properties of yellow lentil protein concentrate

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    There is a growing interest in utilizing plant proteins as functional ingredients in foods, in an effort to address the consumer demand for ‘clean label’ or only natural ingredients in foods. Plant proteins can be used as emulsifiers, foaming agents and fat binding agents in order to replace synthetic food surfactants such as Sodium Tri-polyphosphate. High Pressure Processing (HPP) can bring about structural modifications in the plant proteins and increase their functionality. The aim of this project was to study the effect of High Pressure Processing parameters on selected physicochemical and functional properties of yellow lentil protein concentrate. Yellow lentil protein concentrate (YLPC) solutions (10% w/w) were subjected to high pressure processing, followed by freeze drying. Experiments based on Box- Behnken (BBD) design were carried out, with Pressure (MPa), time (min), and pH of the protein solution as the three independent factors. The freeze dried samples were then analysed for emulsification capacity, foaming ability, solubility, fat binding capacity, surface hydrophobicity, and surface zeta potential. These analyses were carried out in two different pH systems, namely, pH = 3 and pH = 7. Unprocessed yellow lentil protein concentrate was used as the control It was observed that lower pressures and intermediate treatment times at neutral pH (=7) protein solutions were most effective in improving the functional properties of the protein. The solubility of the protein in a pH 7 system increased from 40% ± 3% for unprocessed control to 50% ± 5% for the sample processed at 150 MPa. The emulsifying ability of the protein decreased at higher pressures of 350 MPa and 550 MPa. In the pH 3 system, the droplet size of the dispersed phase of the emulsion stabilized by the protein sample processed at 550 MPa increased to 24 µm ± 0.2 µm from 16 µm ± 0.5 µm for the unprocessed control. Similarly, in the pH 7 system, the droplet size increased from 8 µm ± 1.5 µm for the emulsion stabilized by the unprocessed control to about 11 µm ± 2 µm for emulsion stabilized by the protein sample treated at 550 MPa. However, samples processed at these pressures imparted higher stability to the emulsions- around 89% ± 2% compared to 82% ± 3% for the emulsions stabilized by the unprocessed control. Foaming ability was not significantly affected by the HPP treatment in both systems: pH 3 and pH 7. The surface hydrophobicity increased from H0 = 2800 ± 228 for unprocessed control to H0 = 6400± 51 for the sample processed at 350 MPa Surface zeta potential was not significantly affected by the three independent factors studied. Different factors or combination of factors played a significant role in the changes in each of these functional properties. In conclusion, pressure treatments at lower pressures (150 MPa, 10 min) at neutral pH were found to be better at improving the functional properties compared to higher pressures and longer times at lower or neutral pH values.M.S.Includes bibliographical reference

    Proceedings of the 2016 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Scientific Meeting

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    Table of Contents P1 Serologic evidence of gut-driven systemic inflammation in juvenile idiopathic arthritis Lampros Fotis, Nur Shaikh, Kevin Baszis, Anthony French, Phillip Tarr P2 Oral health and anti-citrullinated peptide antibodies (ACPA) in juvenile idiopathic arthritis Sriharsha Grevich, Peggy Lee, Sarah Ringold, Brian Leroux, Hannah Leahey, Megan Yuasa, Jessica Foster, Jeremy Sokolove, Lauren Lahey, William Robinson, Joshua Newsom, Anne Stevens P3 Novel autoantigens for endothelial cell antibodies in pediatric rheumatic diseases identified by proteomics Rie Karasawa, Mayumi Tamaki, Megumi Tanaka, Toshiko Sato, Kazuo Yudoh, James N. Jarvis P4 Transcriptional profiling reveals monocyte signature associated with JIA patient poor response to methotrexate Halima Moncrieffe, Mark F. Bennett, Monica Tsoras, Lorie Luyrink, Huan Xu, Sampath Prahalad, Paula Morris, Jason Dare, Peter A. Nigrovic, Margalit Rosenkranz, Mara Becker, Kathleen M. O’Neil, Thomas Griffin, Daniel J. Lovell, Alexei A. Grom, Mario Medvedovic, Susan D. Thompson P5 A multi-dimensional genomic map for polyarticular juvenile idiopathic arthritis Lisha Zhu, Kaiyu Jiang, Laiping Wong, Michael J Buck, Yanmin Chen, Halima Moncrieffe, Laura Brungs, Tao Liu, Ting Wang, James N Jarvis P6 Tocilizumab for treatment of children with refractory JIA Khaled Alsaeid, Jasim Alfailakawi, Hamid Alenezi, Hazim Alsaeed P7 Clinical characteristics of the initial patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry Tim Beukelman, Marc Natter, Norm Ilowite, Kelly Mieszkalski, Grendel Burrell, Brian Best, Helen Bristow, Shannon Carr, Anne Dennos, Rachel Kaufmann, Yukiko Kimura, Laura Schanberg P8 Comparative performance of small and large clinical centers in a comprehensive pediatric rheumatology disease registry Peter R Blier P9 Clinical characteristics of children with membranous lupus nephritis: The Childhood Arthritis and Rheumatology Research Alliance Legacy Registry Alexis Boneparth, Scott E. Wenderfer, L. Nandini Moorthy, Suhas M. Radhakrishna, Anna Carmela P. Sagcal-Gironella, Emily von Scheven P10 Rituximab use in pediatric lupus anticoagulant hypoprothrombinemia syndrome - a two center experience Kader Cetin Gedik, Salma Siddique, Cassyanne L. Aguiar, Doruk Erkan P11 Predictors of complementary and alternative medicine use and response in children with musculoskeletal conditions Ezra Cohen, Yvonne Lee, Michelle Dossett, Darshan Mehta, Roger Davis P12 Comparison of pediatric rheumatology and nephrology survey results for the treatment of refractory proliferative lupus nephritis and renal flare in juvenile SLE Mileka Gilbert, Beatrice Goilav, Esra Meidan, Joyce Hsu, Alexis Boneparth, Anabelle Chua, Stacy Ardoin, Scott E. Wenderfer, Emily Von Scheven, Natasha M. Ruth P13 Transitioning lupus patients from pediatric to adult rheumatology Joyce Hui-Yuen, Kader Cetin Gedik, Liza Bermudez, Ashlea Cook, Lisa Imundo, Amy Starr, Andrew Eichenfield, Anca Askanase P14 The systemic juvenile idiopathic arthritis cohort of the Childhood Arthritis & Rheumatology Research Alliance Registry Ginger Janow, Laura E. Schanberg, Soko Setoguchi, Victor Hasselblad, Elizabeth D. Mellins, Rayfel Schneider, Yukiko Kimura, The CARRA Legacy Registry Investigators P15 Results of the pilot study of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus treatment plans for new-onset systemic juvenile idiopathic arthritis Yukiko Kimura, Sriharsha Grevich, Timothy Beukelman, Esi Morgan, T Brent Graham, Maria Ibarra, Yonit Sterba Ruas, Marisa Klein-Gitelman, Karen Onel, Sampath Prahalad, Marilynn Punaro, Sarah Ringold, Dana Toib, Heather Van Mater, Jennifer E. Weiss, Pamela F. Weiss, Kelly Mieszkalski, Laura E. Schanberg P16 A systemic review of pain relief modalities in juvenile idiopathic arthritis: First step in developing a novel decision support intervention Timothy S. H. Kwok, Jacinthe Bisaillon, Christine Smith, Lucie Brosseau, Jennifer Stinson, Adam M. Huber, Ciaran M. Duffy, Karine Toupin April P17 Barriers and facilitators to care retention for pediatric systemic lupus erythematous patients in South Africa: A qualitative study Laura B Lewandowski, Christiaan Scott P18 Evaluating the feasibility of conducting comparative effectiveness studies in juvenile Localized Scleroderma (jLS) Suzanne C. Li, Kathryn S. Torok, C. Egla Rabinovich, Sandy D. Hong, Mara L Becker, Fatma Dedeoglu, Maria F. Ibarra, Polly J Ferguson, Rob C. Fuhbrigge, Katie G. Stewart, Elena Pope, Ronald M. Laxer, Thomas G. Mason, Gloria C. Higgins, Xiaohu Li, Marilynn G. Punaro, George Tomlinson, Eleanor Pullenayegum, John Matelski, Laura Schanberg, Brian M. Feldman P19 Tonsillar histology in patients with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome Kalpana Manthiram, Hernan Correa, Kathryn Edwards P20 Clinical course of juvenile dermatomyositis presenting as skin predominant disease Edward J. Oberle, Michelle Bayer, Dominic O. Co, Hatice Ezgi Baris, Yvonne Chiu, Adam Huber, Susan Kim P21 A Survey of musculoskeletal ultrasound practices of pediatric rheumatologists in North America Edward J Oberle, Timothy Beukelman P22 Assessment, classification and treatment of calcinosis as a complication of juvenile dermatomyositis: A survey of pediatric rheumatologists by the Childhood Arthritis and Rheumatology Research Alliance Amir B. Orandi, Kevin W. Baszis, Vikas Dharnidharka, Mark F. Hoeltzel, for the CARRA JDM Committee P23 CARRA dermatomyositis CTP pilot study Ann Reed, Adam Huber, George Tomlinson, Eleanor Pullenayegum, John Matelski, Y. Ingrid Goh, Laura Schanberg, Brian M. Feldman P24 Unexpectedly high incidences and prolonged disease activity in children with chronic non-bacterial osteomyelitis (CNO) as compared to bacterial osteomyelitis Anja Schnabel, Ursula Range, Gabriele Hahn, Timo Siepmann, Reinhard Berner, Christian Michael Hedrich P25 Juvenile systemic sclerosis cohort within the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry: Follow up characteristics Brandi Stevens, Kathryn S. Torok, Suzanne Li, Nicole Hershey, Megan Curran, Gloria Higgins, Katharine Moore, Egla Rabinovich, Anne M. Stevens, for the CARRA Registry Investigators P26 Development and usability testing of an iPad and desktop psycho-educational game for children with Juvenile Idiopathic Arthritis and their parents Jennifer Stinson, Mark Connelly, Adam Huber, Nadia Luca, Lynn Spiegel, Argerie Tsimicalis, Stephanie Luca, Naweed Tajuddin, Roberta Berard, Julia Barsalou, Sarah Campillo, Paul Dancey, Ciaran Duffy, Brian Feldman, Nicole Johnson, Patrick McGrath, Natalie Shiff, Shirley Tse, Lori Tucker, Charles Victor P27 iCanCope TM: User-centred design and development of a smartphone app to support self-management for youth with arthritis pain Jennifer Stinson, Chitra Lalloo, Lauren Harris, Joseph Cafazzo, Lynn Spiegel, Brian Feldman, Nadia Luca, Ronald Laxer P28 Accessing pediatric rheumatology care: Despite barriers, few parents prefer telemedicine Danielle R. Bullock, Richard K. Vehe, Lei Zhang, Colleen K. Correll1 P29 Exploration of factors contributing to time to achieve clinically inactive disease (CID) in juvenile idiopathic arthritis (JIA): A preliminary report Suhas Ganguli, Max Shenberger, Ritesh Korumilli, Beth Gottlieb P30 Pediatric rheumatology referral patterns: Presenting complaints of new patients at a large, urban academic center Martha Rodriguez, Deirdre de Ranieri, Karen Onel, Linda Wagner-Weiner, Melissa Tesher P31 Quality improvement (QI) initiatives in childhood systemic lupus erythematosus (cSLE) Elizabeth Roth Wojcicki, Kristyn L. Maletta, Dominic O. Co, Marsha Malloy, Sarah Thomson, Judyann C. Olson P32 Proliferative lupus nephritis in juvenile SLE: Support from the pediatric nephrology community for the definitions of responsiveness and flare in the 2012 consensus treatment plans Scott E. Wenderfer, Mileka Gilbert, Joyce Hsu, Sangeeta Sule, Tamar B. Rubinstein, Beatrice Goilav, Daryl M. Okamura, Annabelle Chua, Laurence A. Greenbaum, Jerome C. Lane, Emily von Scheven, Stacy P. Ardoin, Natasha M. Ruth P33 The steroid taper app: Making of a mobile app Jennifer M. P. Woo, Marsha M. Malloy, James A. Jegers, Dustin J. Hahn, Mary K. Hintermeyer, Stacey M. Martinetti, Gretchen R. Heckel, Elizabeth L. Roth-Wojcicki, Dominic O. C
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