25,195 research outputs found
Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors
No full textGABA(A) receptors are the principal sites of fast synaptic inhibition in the brain. These receptors are hetero-pentamers that can be assembled from a number of subunit classes: alpha(1-6), beta(1-3), gamma(1-3), delta(1), epsilon, theta, and pi, but the majority of receptor subtypes is believed, however, to be composed of alpha, beta, and gamma2 subunits. A major mechanism for modulating GABA(A) receptor function occurs via the phosphorylation of residues within the intracellular domains of receptor subunits by a range of serine/ threonine and tyrosine kinases. However, how protein kinases are targeted to these receptors to facilitate functional modulation remains unknown. Here we demonstrate that the receptor for activated C kinase (RACK-1) and protein kinase C (PKC) bind to distinct sites on GABA(A) receptor beta subunits. Although RACK-1 is not essential for PKC binding to GABAA receptor beta subunits, it enhances the phosphorylation of serine 409, a residue critical for the phospho-dependent modulation of GABA(A) receptor function in the beta1 subunit by anchored PKC. Furthermore, RACK-1 also enhances GABA(A) receptor functional modulation in neurons by a PKC-dependent signaling pathway with the activation of muscarinic acetylcholine receptors (mAChRs). This PKC-dependent modulation of neuronal GABAA receptors was mirrored by an increase in the phosphorylation of GABA(A) receptor beta subunits with the activation of mAChRs.Our results suggest a central role for RACK-1 in potentiating PKC-dependent phosphorylation and functional modulation of GABA(A) receptors. Therefore, RACK-1 will enhance functional cross talk between GABA(A) receptors and G-protein-coupled receptors and therefore may have profound effects on neuronal excitability
Vertical rack
No full textTarget of master thesis is constructional design of vertical rack with press of screenings for shaft type 501 up to 3200 mm deep. Part of this shaft system is atypical bottom with two inflows and one outflow of sewage water. According to these requirements there ware adapted dimensions and shapes of whole construction. Master thesis is divided into several parts, where is disposed construction design of rack with supplement, modification of shaft bottom and embedment of vertical rack
Elementary school children browse magazines, Martin Luther King, Jr. School, approximately 1971
No full textA black and white photograph of two elementary school children, as they pose for a portrait while browsing in front of a magazine rack at Martin Luther King, Jr. Elementary School in Toledo, Ohio. Photo was taken by commercial photographer Bill Langhorst around 1971
Hat Display Rack.
No full textPatent for an improved hat display rack that can display a full line of hats. Illustrations and instructions included
Structure theory of Rack-Bialgebras
No full textArticle ID 1000244, 20 pp.International audienceIn this paper we focus on a certain self-distributive multiplication on coalgebras, which leads to so-called rack bialgebra. Inspired by semi-group theory (adapting the Suschkewitsch theorem), we do some structure theory for rack bialgebras and cocommutative Hopf dialgebras. We also construct canonical rack bialgebras (some kind of enveloping algebras) for any Leibniz algebra and compare to the existing constructions. We are motivated by a differential geometric procedure which we call the Serre functor: To a pointed differentible manifold with multiplication is associated its distribution space supported in the chosen point. For Lie groups, it is well-known that this leads to the universal enveloping algebra of the Lie algebra. For Lie racks, we get rack-bialgebras, for Lie digroups, we obtain cocommutative Hopf di-algebras
Jack Alive / Martin Dead : The Location of the "Author" in Jack London\u27s Martin Eden
No full textThis essay is an attempt to read Martin Eden, Jack Londonʼs autobiographical novel, in terms of the inextricable relationship between the author and the protagonist. Critics have often taken the unbalanced plot and the lack of ironic distance between narrator and character in Martin Eden as the technical weakness of London, but this paper argues that the achievement of this novel owes a great deal to the attachment of London to Martin. The unbalanced structure is a necessary product of the severe struggle of the author to kill his romantic alter ego. // Martin, who aspires to win Ruth Morse, tries to cross class boundaries by making a career of a writer. Even after realizing the emptiness of Ruth, who turns out to be nothing but a typical figure of the bourgeoisie, he somehow persists in loving her. The notion underlying here is that, for Martin, love, career and art are fundamentally inseparable. He objects to the aestheteʼs view of Brissenden on account of his separation of art from career. Martinʼs identity and life consist only in the triunity of love/career/art; the alternative is the repudiation of life. Thus, the unnatural delay of his disappointment in love can be regarded as Londonʼs strategy to set the suicide of Martin as the necessary consequence of the story. // By finishing the story and killing Martin, London finally detaches himself from Martin, reconstructs his self, and, unlike Martin, survives as a professional writer. In this sense, Martin Eden is a story about “writerʼs self-reconstruction.
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Letter from Martin Chizzick
No full textCongratulations to Duane Pearsall for receiving the Enterpreneur of the Year award; note on the letter was written by Pearsall and it mentions that Martin, the author of the letter, died in a airplane accident
Robert Martin Tiffin's Mystery Man Newspaper Articles
No full textAdvertiser-Tribune newspaper clippings featuring a story about Robert Martin (written by Nancy Kleinhenz), a local author from Tiffin (Ohio) who wrote under the pseudonym of Lee Roberts, and two of his short stories. Martin wrote mystery novels in his spare time, creating more than 22 mystery novels. For more information about Robert Martin and a list of books go to http://www.mysteryfile.com/RMartin/JBennett.html
Martin Dies, Jr. State Park [Rack Card]
No full textCard advertising Martin Dies, Jr. State Park with brief descriptive information and a summary of activities, facilities, and other features of the location
Martin Creek Lake State Park [Rack Card]
No full textCard advertising Martin Creek Lake State Park with brief descriptive information and a summary of activities, facilities, and other features of the location
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