1,721,220 research outputs found
Eccellente lavoro e significativo sulla peripheral perfusion and plasma adrenomedullin in N-Acetylcysteine long term treatment of patients with sclerodermic Raynaud’s
No full textThe aim of our study is to evaluate in Systemic Sclerosis (SSc) male patients the tadalafil effects on Raynaud's phenomenon and on AM and ET-1 plasma levels. In an open-label study 20 consecutive male patients with SSc were enrolled and received 10 mg of tadalafil daily for 12 weeks. The primary endpoint was the subjective reduction of frequency and duration of Raynaud's attacks measured with a 10-point Raynaud's Condition Score; the secondary aim was to modify Adrenomedullin (AM) and Endothelin-1 (ET-1) plasma levels. After the treatment Raynaud's phenomenon was improved by once-daily tadalafil (decrease of mean number of Raynaud's attacks and of Raynaud's Condition Score) and plasma AM and ET-1 levels decreased. The results of our study lead us to postulate the beneficial effect of adding long term inhibition of Phosphodiesterase type 5 to Systemic Sclerosis' therapy
Microcircolo e carnitina
No full textNella patogenesi di numerose condizioni morbose è evidenziabile un danno anatomico e/o funzionale del microcircolo. La disfunzione del microcircolo comporta una riduzione del flusso arterioso nel distretto interessato. L’approccio terapeutico attuale prevede l’eliminazione delle cause scatenanti e una rivascolarizzazione chirurgica, laddove necessaria, in associazione con farmaci anticoagulanti o antiaggreganti. Il supplemento di farmaci con attività antiossidante, in associazione alla terapia di base, è utile in tutte quelle patologie nella cui patogenesi è riscontrabile un’alterazione anatomica e funzionale del microcircolo. Nel presente articolo viene trattato il possibile uso della carnitina come farmaco antiossidante in quelle malattie nelle quali la disfunzione del microcircolo gioca un ruolo chiave
Immunity, autoimmunity and autoimmune diseases in older people
No full textImmunosenescence is defined as all the changes occurring in the immune system in the aged. Recent studies suggest that in older patients the immune system undergoes a functional remodelling. Two contrasting phenomena coexist in immunosenescence: the decreasing of immune response and the autoantibody production. Possible consequences are an increase of autoimmune phenomenon, neoplasia incidence, and predisposition to infections. The study of autoimmune manifestations in the elderly population should be considered as a priority for future medical research because of the increase in life expectancy, especially in developed countries. This review analyzes the clinical expression of systemic autoimmune diseases in older patients. Copyright © by BIOLIFE, s.a.s
Stress e malattie autoimmuni
No full textL'abstract esplora il rapporto tra stress e malattie autoimmun
Fenomeno di Raynaud
No full textIl capitolo dell'enciclopedia affronta le generalità, l'epidemiologia, la patogenesi, il quadro clinico, la diagnosi e la terapia del fenomeno di Ranaud primitivo e secondario
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