1,721,426 research outputs found
Scleromyxedema with an interstitial granulomatous-like pattern: A rare histologic variant mimicking granuloma annulare
No full textScleromyxedema is the generalized and sclerodermoid form of lichen myxedematosus. Its typical histological features include a diffuse deposition of mucin in the papillary and mid reticular dermis, an increased of collagen deposition, and a proliferation of irregularly arranged fibroblasts. We describe a 76-year-old man presenting with scleromyxedema associated with IgGλ monoclonal gammopathy whose biopsy showed histological features of an interstitial granulomatous-like process consistent with interstitial granuloma annulare. The significance of these unusual granulomatous findings in the setting of scleromyxedema are unknown and have been described only once in the literature. This observation expands the spectrum of scleromyxedema and highlights the difficulty in diagnosing this disabling condition. Rongioletti F, Cozzani E, Parodi A. Scleromyxedema with an interstitial granulomatous-like pattern: a rare histologic variant mimicking granuloma annulare
Scleromyxedema: A potentially disabling and fatal disease
No full textScleromyxedema (SCL), considered to be the generalized and sclerodermoid subtype of lichen myxedematosus (papular mucinosis), is a disease with a chronic, progressive, and potentially disabling course. It is usually, although not invariably, associated with a monoclonal gammopathy which rarely leads to multiple myeloma and with many systemic manifestations. The therapy is difficult and the prognosis is guarded. The author, on the basis of literature and personal experience, review the anatomo-clinical manifestations of this uncommon disease
Complications granulomateuses des techniques de comblement
No full textGranulomatous reactions to dermal fillers for tissue augmentation is a rare but possible late complication occurring both with permanent (more frequent) and biodegradable or resorbable products. Predictions cannot be made for possible late reactions, sometimes occurring even after 18 years. Although clinical diagnosis seems to be an easy task, the issue is sometimes challenging if cosmetic intervention is denied or not mentioned by the patient or by the referring physician. Identifying the filler is therefore difficult and experts may be called in trials to solve the problem. Histopathology is the best means to obtain the correct diagnosis and to identify the type of filler particles. In fact, the particular configuration of the vacuoles and cystic structures inside the granulomas reflects the shape of the injected implants particles. The clinical and microscopic features, the pathogenesis and the treatment of the granulomatous reactions to dermal fillers for tissue augmentation will be presented and discussed. © 2008 Elsevier Masson SAS. Tous droits réservés
Primary paediatric cutaneous mucinoses
No full textPrimary cutaneous mucinoses are a heterogeneous group of diseases characterized by the abnormal deposition of glycosaminoglycans (mucin) in the skin. This is the main histopathological clue resulting in distinctive clinical presentations. They are usually diseases of adult age and are uncommon in children, in whom diagnosis and management are difficult tasks. In particular, the classification of primary cutaneous mucinoses occurring in childhood is a difficult and confusing challenge because of the very limited number of described cases and overlaps in their clinicopathological features in the absence of reports of homogeneous case series
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