102,157 research outputs found
Tapentadol for neuropathic pain: a review of clinical studies
Get PDFUlderico Freo,1 Patrizia Romualdi,2 Hans G Kress31Anesthesiology and Intensive Medicine, Department of Medicine DIMED, University of Padua, 35100 Padua, Italy; 2Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, 40126, Bologna, Italy; 3Department of Special Anaesthesia and Pain Medicine, Medical University/AKH of Vienna, Vienna, AustriaAbstract: Neuropathic pain (NP) is an enormous burden for patients, caregivers and society. NP is a pain state that may develop after injury of the peripheral or central nervous system because of a wide range of diseases and traumas. A NP symptom component can be found also in several types of chronic pain. Many NP patients are substantially disabled for years. Due to its chronicity, severity and unpredictability, NP is difficult to treat. Tapentadol is a central-acting oral analgesic with combined opioid and noradrenergic properties, which make it potentially suitable for a wide range of pain conditions, particularly whenever a NP component is present or cannot be excluded. In randomized controlled trials, tapentadol has proved to be effective in relieving NP in diabetic peripheral neuropathy and in chronic low back pain. In observational studies, tapentadol reduced NP in chemotherapy-induced peripheral neuropathies, blood and solid cancers, and the NP component in neck pain and Parkinson’s disease. This narrative review aims to provide clinicians with a broad overview of tapentadol effects on NP.Keywords: neuropathic pain, tapentadol, pain therap
2. In memoria di Erico Paribeni, G. Capecchi, O. Paoletti, A. M. Esposito & A. Romualdi edd.
No full textHinard François. 2. In memoria di Erico Paribeni, G. Capecchi, O. Paoletti, A. M. Esposito & A. Romualdi edd.. In: Revue des Études Grecques, tome 112, Janvier-juin 1999. p. 271
La perdita del capitale sociale nelle società in crisi
No full textLa perdita del capitale sociale rappresenta un passaggio significativo nella vita dell’impresa, incidendo sull’equilibrio patrimoniale, sulla posizione dei creditori e sui poteri e responsabilità dell’organo amministrativo. Il volume analizza in modo sistematico la disciplina di conservazione del capitale nelle società di capitali, soffermandosi sul coordinamento con la normativa della crisi d’impresa e sull’integrazione con i doveri degli amministratori, anche mediante un’analisi comparatistica con l’ordinamento spagnolo. Ne risulta un quadro nel quale le regole sul capitale sociale e gli obblighi gestorî si integrano reciprocamente, contribuendo alla protezione dei creditori nelle diverse fasi della vita societaria
Substance P is diminished and vasoactive intestinal peptide is augmented in psoriatic lesions and these peptides exert disparate effects on the proliferation of cultured human keratinocytes
No full textAn involvement of neurogenic components in the pathogenesis of psoriatic lesions has been suggested and neuropeptides are thought to play a modulatory role in cutaneous inflammation. In this study, we evaluated the immunoreactivity of the neuropeptides vasoactive intestinal polypeptide (VIP) and substance P (SP) in the skin of patients with chronic plaque psoriasis, by immunohistochemistry and radioimmunoassay. No differences were observed, by immunohistochemistry, in the expression and localization of VIP and SP between psoriatic and normal skin. Using the radioimmunologic technique on whole skin homogenates, VIP levels were significantly increased in psoriatic lesions as compared to normal skin. By contrast, SP levels were significantly lower in lesional and non-lesional psoriatic skin than in normal skin. In addition, we examined the effect of VIP and SP on the proliferation of cultured normal human keratinocytes. VIP (1-28) (1 nM-1μM) as well as VIP fragments (10-28) (1 nM-1 μM) and (22-28) (1 nM-1μM) stimulated the proliferation of keratinocytes in a dose-dependent manner, whereas the VIP fragment (1-12) (1 nM-1 μM) was ineffective. The VIP antagonist (N-Ac-Tyr1, D-Phe2)-GRF (1-29)-NH2 (0.1 μM) significantly inhibited the VIP effect on keratinocytes. On the other hand, SP (0.1 μM) not only failed to stimulate keratinocyte growth, but also blocked the VIP-induced stimulation of these cells. The imbalance of cutaneous VIP and SP and their disparate effects on the proliferation of normal human keratinocytes in culture would suggest that these peptides are involved in the pathogenesis of psoriasis and may exert different modulatory activities in the mechanisms underlying the psoriatic lesion. © 1992
Profili in tema di responsabilità degli amministratori per l’illegittimo rimborso dei finanziamenti dei soci in una situazione di crisi
No full textg<monospace>raphite</monospace> - a Bioconductor package to convert pathway topology to gene network
Get PDFAbstract Background Gene set analysis is moving towards considering pathway topology as a crucial feature. Pathway elements are complex entities such as protein complexes, gene family members and chemical compounds. The conversion of pathway topology to a gene/protein networks (where nodes are a simple element like a gene/protein) is a critical and challenging task that enables topology-based gene set analyses. Unfortunately, currently available R/Bioconductor packages provide pathway networks only from single databases. They do not propagate signals through chemical compounds and do not differentiate between complexes and gene families. Results Here we present graphite, a Bioconductor package addressing these issues. Pathway information from four different databases is interpreted following specific biologically-driven rules that allow the reconstruction of gene-gene networks taking into account protein complexes, gene families and sensibly removing chemical compounds from the final graphs. The resulting networks represent a uniform resource for pathway analyses. Indeed, graphite provides easy access to three recently proposed topological methods. The graphite package is available as part of the Bioconductor software suite. Conclusions graphite is an innovative package able to gather and make easily available the contents of the four major pathway databases. In the field of topological analysis graphite acts as a provider of biological information by reducing the pathway complexity considering the biological meaning of the pathway elements.</p
Il Sistema Oppioide
No full textIl sistema oppioide rapppresenta uno dei sistemi endogeni di neurotrasmissione/neuromodulazione ed è costitutito da specifici ligandi di natura peptidica e relativi recettori. Esso è presente a livello dell'S.N.C. ed in periferia ed è coinvolto nella modulazione di differenti e numerose funzioni
In memoria di Enrico Paribeni. - A cura di G. Capecchi, O. Paoletti, e. Cianferoni, A.-M. Esposito et A. Romualdi. (Archaeologica, ISSN : 0391- 9293 ; n° 125), 1998
No full textHalm-Tisserant Monique. In memoria di Enrico Paribeni. - A cura di G. Capecchi, O. Paoletti, e. Cianferoni, A.-M. Esposito et A. Romualdi. (Archaeologica, ISSN : 0391- 9293 ; n° 125), 1998. In: Revue des Études Anciennes. Tome 104, 2002, n°1-2. p. 237
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