1,723,317 research outputs found
Note sull’uso efficiente dei pannelli solari
No full textQueste note derivano dalla mia esperienza nell’uso di pannelli solari, maturata in istallazioni in Africa,
in Antartide e sui palloni stratosferici. Si tratta di considerazioni, essenzialmente votate a trarre dal
fotovoltaico tutta l’energia possibile, nate sul campo dalle necessità del problema tecnico, ed organizzate per
scrivere questa nota. Si parla di installazioni fisse o su veicolo, e non si trattano i sistemi ad inseguimento.
Tutte le considerazioni sono di principio, e non si scende troppo nei dettagli realizzativi. Sono convinto che il
lettore tecnico cui sono destinate sia abbastanza smaliziato da non richiedere minuzie circuitali.Published1-302IT. Laboratori sperimentali e analiticiN/A or not JCRope
Note sull’uso efficiente dei pannelli solari
No full textQueste note derivano dalla mia esperienza nell’uso di pannelli solari, maturata in istallazioni in Africa,
in Antartide e sui palloni stratosferici. Si tratta di considerazioni, essenzialmente votate a trarre dal
fotovoltaico tutta l’energia possibile, nate sul campo dalle necessità del problema tecnico, ed organizzate per
scrivere questa nota. Si parla di installazioni fisse o su veicolo, e non si trattano i sistemi ad inseguimento.
Tutte le considerazioni sono di principio, e non si scende troppo nei dettagli realizzativi. Sono convinto che il
lettore tecnico cui sono destinate sia abbastanza smaliziato da non richiedere minuzie circuitali.Published1-302IT. Laboratori sperimentali e analiticiN/A or not JCRope
Deconvolving seismic signals with a SPICE model of the seismometer
No full textAbstract Every transducer needs some deconvolution
operation to return the original signal. In the seismometer’s
case, this is usually done by using the pole-zero
instrument models. This method assumes that the seismometer
can be described by a linear model that can be
schematized by a ratio of polynomials of the Laplace
variable s. This paper shows a deconvolution method
that uses the mechanic-electric model of a transducer.
Such a model can also give a better description of a
transducer since it can also take into account nonlinear
behavior which cannot be included in pole-zero models.
Examples of deconvolution of both linear and nonlinear
transfer functions are shown, and some considerations
about friction damping and the electromechanical analogies
used to perform the simulations are included in the appendix.Published533–5411IT. Reti di monitoraggio e OsservazioniJCR Journalope
Establishment of the antiviral state in alpha, beta interferon-resistant Friend cells treated with gamma interferon: induction of 67K protein kinase activity in absence of detectable 2-5A synthetase
No full textTreatment with murine gamma-interferon (IFN) preparations of variant sublines of Friend leukemia cells resistant to the alpha, beta IFN-induced antiviral state (Affabris, E., Jemma, C., and Rossi, G.B. (1982) Virology 120, 441-452; Affabris, E., Romeo, G., Belardelli, F., Jemma, C., Mechti, N., Gresser, I., and Rossi, G. B. (1983) Virology 125, 508-512) results in the establishment of a bona fide antiviral state. In fact, gamma IFN preparations are able to induce a dose-dependent reduction of endogenous virus release and of vesicular stomatitis or encephalomyocarditis viruses yields (up to 1.5 log). Under these experimental conditions, no inducible 2-5A synthetase activity is detectable in cell extracts. The 67-kDa protein kinase, uninducible by treatment with alpha, beta IFN (up to 13,000 units/ml), is instead induced upon treatment with gamma IFN at a similar rate of activity as in wild-type Friend leukemia cells, both when assayed in solution and after immobilization on poly(rI) X poly(rC)-agarose
H+-slip correlated to rotor free-wheeling as cause of F1FO-ATPase dysfunction in primary mitochondrial disorders
Full text link: Inborn errors of metabolism are related to mitochondrial disorders caused by dysfunction of the oxidative phosphorylation (OXPHOS) system. Congenital hypermetabolism in the infant is a rare disease belonging to Luft syndrome, nonthyroidal hypermetabolism, arising from a singular example of a defect in OXPHOS. The mitochondria lose coupling of mitochondrial substrates oxidation from the ADP phosphorylation. Since Luft syndrome is due to uncoupled cell respiration responsible for deficient in ATP production that originates in the respiratory complexes, a de novo heterozygous variant in the catalytic subunit of mitochondrial F1 FO -ATPase arises as the main cause of an autosomal dominant syndrome of hypermetabolism associated with dysfunction in ATP production, which does not involve the respiratory complexes. The F1 FO -ATPase works as an embedded molecular machine with a rotary action using two different motor engines. The FO , which is an integral domain in the membrane, dissipates the chemical potential difference for H+ , a proton motive force (Δp), across the inner membrane to generate a torsion. The F1 domain-the hydrophilic portion responsible for ATP turnover-is powered by the molecular rotary action to synthesize ATP. The structural and functional coupling of F1 and FO domains support the energy transduction for ATP synthesis. The dissipation of Δp by means of an H+ slip correlated to rotor free-wheeling of the F1 FO -ATPase has been discovered to cause enzyme dysfunction in primary mitochondrial disorders. In this insight, we try to offer commentary and analysis of the molecular mechanism in these impaired mitochondria
‘Rotor free-wheeling’ in impaired F1FO-ATPase induces congenital hypermetabolism
Full text linkA de novo heterozygous variant in the catalytic subunit of mitochondrial F1FO-ATPase has been recently discovered by Ganetzky et al. to be the main cause of an autosomal dominant syndrome of hypermetabolism associated with defective ATP production. We describe how the ‘rotor free-wheeling’ causes this F1FO-ATPase dysfunction in primary congenital hypothyroidism
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